Polycystic Kidney Disease Pathway (Homo sapiens)

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Description

A putative PKD pathway proposed in Torres 2009 (Figure 2), showing up or down regulated genes.

Ontology Terms

 

Bibliography

  1. Torres VE, Harris PC; ''Autosomal dominant polycystic kidney disease: the last 3 years.''; Kidney Int, 2009 PubMed

History

View all...
CompareRevisionActionTimeUserComment
88333view15:54, 1 August 2016FehrhartOntology Term : 'kidney disease pathway' added !
84489view23:15, 25 February 2016KhanspersQuick edit to datanode annotation or property
79790view16:02, 16 April 2015Mkutmonfixed unconnected line
78508view10:29, 7 January 2015MaintBotadded missing graphIds
78125view16:17, 4 December 2014Mkutmonadded more xrefs and some layout changes
78124view15:48, 4 December 2014Mkutmonadded some xrefs
78123view15:23, 4 December 2014Mkutmonremoved fill color since it is not ideal for visualization
74333view21:14, 12 April 2014EgonwModified description
71048view18:21, 25 September 2013EgonwAdded several identifiers.
71047view17:19, 25 September 2013EgonwCompleted entering all entities.
71046view13:06, 25 September 2013EgonwAdded identifiers for two PKD genes.
71045view11:47, 25 September 2013EgonwMore pathway content.
71044view11:16, 25 September 2013EgonwMore entities. Prob. 20% done now, excl identifiers.
71043view10:49, 25 September 2013EgonwModified description
71042view10:47, 25 September 2013EgonwNew pathway

External references

Datanodes

View all...
NameTypeDatabase referenceComment
beta-Catenin
ADPMetaboliteCHEBI:16761 (ChEBI)
AMPGeneProduct
AMPMetaboliteCHEBI:16027 (ChEBI)
AMPKGeneProduct
ATPMetabolite
ATPMetaboliteCHEBI:15422 (ChEBI)
ATPase
Ac-VI
BRAFGeneProductENSG00000157764 (Ensembl)
CDK inhibitorsMetabolite
CTFR inhMetabolite
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cl-Metabolite
Decreased in PKD
Dvl
EGFGeneProductENSG00000138798 (Ensembl)
ERKGeneProduct
Frizzled
GSK3betaGeneProduct
Gi
Gq
Gs
IGF1GeneProductENSG00000017427 (Ensembl)
IKK2GeneProductENSG00000104365 (Ensembl)
IP3MetaboliteCHEBI:16595 (ChEBI)
Increased in PKD
JUNGeneProductENSG00000177606 (Ensembl)
K+Metabolite791 (Chemspider)
KCa3.1 inhMetabolite
KCa3.1GeneProductENSG00000104783 (Ensembl)
LKB1GeneProductENSG00000118046 (Ensembl)
MEK inhMetabolite
MEKGeneProductENSG00000095015 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
MetforminMetabolite
NKCC1
Na+Metabolite923 (PubChem-compound)
Na+MetaboliteCHEBI:29101 (ChEBI)
Nucleus
PC1GeneProductENSG00000008710 (Ensembl) Also known as PKD1.
PC2GeneProductENSG00000118762 (Ensembl) Also known as PKD2.
PDEGeneProduct
PKA
PLCgammaGeneProduct
ProteasomePathway
Protein SynthesisPathway
R
RHEBGeneProductENSG00000106615 (Ensembl)
RSKGeneProduct
RasGeneProduct
SOCGeneProduct
SRCGeneProductENSG00000197122 (Ensembl)
SomatostatinMetaboliteHMDB13072 (HMDB)
Src inhMetabolite
TKIsMetabolite
TNF anatagonistMetabolite
TNFGeneProductENSG00000232810 (Ensembl)
TNFalphaGeneProductENSG00000204490 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
Triptolide
V2R
V2RA
VEGFGeneProduct
VasopressinMetaboliteHMDB01980 (HMDB)
Wnt
cAMPMetabolite
cyclinDGeneProductENSG00000110092 (Ensembl)
mTOR inhibitorsMetabolite
phos
sFRP4

Annotated Interactions

No annotated interactions

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