Cholesterol Biosynthesis (Homo sapiens)
From WikiPathways
|
Curation Tags
Description
Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria.
Source: Wikipedia
Bibliography
| View all 7 references |
- Liu XY, Dangel AW, Kelley RI, Zhao W, Denny P, Botcherby M, Cattanach B, Peters J, Hunsicker PR, Mallon AM, Strivens MA, Bate R, Miller W, Rhodes M, Brown SD, Herman GE; ''The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase.; ''Nat Genet, 1999 - PubMed
- Sagami H, Korenaga T, Ogura K; ''Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate.; ''J Biochem, 1993 - PubMed
- Noshiro M, Aoyama Y, Kawamoto T, Gotoh O, Horiuchi T, Yoshida Y; ''Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: I. Structural analyses of the gene and multiple sizes of mRNA.; ''J Biochem, 1997 - PubMed
- Gaylor JL; ''Membrane-bound enzymes of cholesterol synthesis from lanosterol.; ''Biochem Biophys Res Commun, 2002 - PubMed
Categories
History
View all |
Pathway Info
DataNodes
| View all 30 DataNodes |
| Name | Type | Backpage Header | Database reference |
|---|---|---|---|
| FDPS | GeneProduct | FDPS | farnesyl diphosphate synthase (farnesyl ... | 2224 (Entrez Gene) |
| Mevalonic acid 5-pyrophosphate | Metabolite | 1492-08-6 (CAS) | |
| IDI1 | GeneProduct | IDI1 | isopentenyl-diphosphate delta isomerase | 3422 (Entrez Gene) |
| Cholesterol | Metabolite | 57-88-5 (CAS) | |
| HMGCS1 | GeneProduct | HMGCS1 | 3-hydroxy-3-methylglutaryl-Coenzyme A ... | 3157 (Entrez Gene) |
