Folate (Homo sapiens)

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  1. Kamagate A, Dong HH; ''FoxO1 integrates insulin signaling to VLDL production.; ''Cell Cycle, 2008 - PubMed
  2. Mayer O Jr, Simon J, Rosolová H, Hromádka M, Subrt I, Vobrubová I; ''The effects of folate supplementation on some coagulation parameters and oxidative status surrogates.; ''Eur J Clin Pharmacol, 2002 - PubMed
  3. Morrow JD, Roberts LJ 2nd.; ''The isoprostanes. Current knowledge and directions for future research.; ''Biochem Pharmacol., 1996 - PubMed
  4. Mancini JA, Abramovitz M, Cox ME, Wong E, Charleson S, Perrier H, Wang Z, Prasit P, Vickers PJ; ''5-lipoxygenase-activating protein is an arachidonate binding protein.; ''FEBS Lett, 1993 - PubMed
  5. Bender DA; ''Biochemistry of tryptophan in health and disease.; ''Mol Aspects Med, 1983 - PubMed
  6. Whanger PD; ''Selenoprotein W: a review.; ''Cell Mol Life Sci, 2000 - PubMed
  7. Lykidis A, Jackson PD, Rock CO, Jackowski S; ''The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content.; ''J Biol Chem, 1997 - PubMed
  8. Liu C, Wang Q, Guo H, Xia M, Yuan Q, Hu Y, Zhu H, Hou M, Ma J, Tang Z, Ling W; ''Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine.; ''J Nutr, 2008 - PubMed
  9. Neumann D, Kollewe C, Resch K, Martin MU.; ''The death domain of IRAK-1: an oligomerization domain mediating interactions with MyD88, Tollip, IRAK-1, and IRAK-4.; ''Biochem Biophys Res Commun, 2007 - PubMed
  10. Ferguson AD, Labunskyy VM, Fomenko DE, Araç D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J; ''NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.; ''J Biol Chem, 2006 - PubMed
  11. Ma Y, Hébert JR, Li W, Bertone-Johnson ER, Olendzki B, Pagoto SL, Tinker L, Rosal MC, Ockene IS, Ockene JK, Griffith JA, Liu S; ''Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study.; ''Nutrition, 2008 - PubMed
  12. Kimura T, Nakanishi K, Nakagawa T, Shibukawa A, Matsuzaki K; ''Simultaneous determination of unbound thyroid hormones in human plasma using high performance frontal analysis with electrochemical detection.; ''J Pharm Biomed Anal, 2005 - PubMed
  13. Hiscott J, Marois J, Garoufalis J, D'Addario M, Roulston A, Kwan I, Pepin N, Lacoste J, Nguyen H, Bensi G; ''Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop.; ''Mol Cell Biol, 1993 - PubMed
  14. Adams RL, Bird RJ; ''Review article: Coagulation cascade and therapeutics update: relevance to nephrology. Part 1: Overview of coagulation, thrombophilias and history of anticoagulants.; ''Nephrology (Carlton), 2009 - PubMed
  15. Anderson ME, Allison RD, Meister A; ''Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids.; ''Proc Natl Acad Sci U S A, 1982 - PubMed
  16. ''; '',
  17. Brigelius-Flohé R; ''Glutathione peroxidases and redox-regulated transcription factors.; ''Biol Chem, 2006 - PubMed
  18. Sakurai T, Yamamoto Y, Baba N, Nakano M; ''Phospholipase A(2) activity in non-glycated and glycated low density lipoproteins.; ''Biochim Biophys Acta, 1996 - PubMed
  19. Packer L, Witt EH, Tritschler HJ; ''alpha-Lipoic acid as a biological antioxidant.; ''Free Radic Biol Med, 1995 - PubMed
  20. Whitaker MO, Wyche A, Fitzpatrick F, Sprecher H, Needleman P; ''Triene prostaglandins: prostaglandin D3 and icosapentaenoic acid as potential antithrombotic substances.; ''Proc Natl Acad Sci U S A, 1979 - PubMed
  21. Holleran WM, Williams ML, Gao WN, Elias PM; ''; '', - PubMed
  22. Huerta C, Borek D, Machius M, Grishin NV, Zhang H; ''Structure and mechanism of a eukaryotic FMN adenylyltransferase.; ''J Mol Biol, 2009 - PubMed
  23. Itabe H; ''Oxidative modification of LDL: its pathological role in atherosclerosis.; ''Clin Rev Allergy Immunol, 2009 - PubMed
  24. Choi SW, Mason JB; ''Folate and carcinogenesis: an integrated scheme.; ''J Nutr, 2000 - PubMed
  25. Bills TK, Smith JB, Silver MJ; ''Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin.; ''J Clin Invest, 1977 - PubMed
  26. Li YC, Chiang CW, Yeh HC, Hsu PY, Whitby FG, Wang LH, Chan NL; ''Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation change.; ''J Biol Chem, 2008 - PubMed
  27. Molnár I, Balázs C, Szegedi G, Sipka S; ''Inhibition of type 2,5'-deiodinase by tumor necrosis factor alpha, interleukin-6 and interferon gamma in human thyroid tissue.; ''Immunol Lett, 2002 - PubMed
  28. Lu C, Qiu F, Zhou H, Peng Y, Hao W, Xu J, Yuan J, Wang S, Qiang B, Xu C, Peng X; ''Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes.; ''FEBS Lett, 2006 - PubMed
  29. Hink HU, Santanam N, Dikalov S, McCann L, Nguyen AD, Parthasarathy S, Harrison DG, Fukai T; ''Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity.; ''Arterioscler Thromb Vasc Biol, 2002 - PubMed
  30. Kainou T, Kawamura K, Tanaka K, Matsuda H, Kawamukai M; ''Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human.; ''Biochim Biophys Acta, 1999 - PubMed
  31. Das UN; ''Folic acid says NO to vascular diseases.; ''Nutrition, 2003 - PubMed
  32. Sneddon AA, Wu HC, Farquharson A, Grant I, Arthur JR, Rotondo D, Choe SN, Wahle KW; ''Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants.; ''Atherosclerosis, 2003 - PubMed
  33. Murakami M, Nakatani Y, Tanioka T, Kudo I; ''Prostaglandin E synthase.; ''Prostaglandins Other Lipid Mediat, 2002 - PubMed
  34. Gladyshev VN, Jeang KT, Wootton JC, Hatfield DL; ''A new human selenium-containing protein. Purification, characterization, and cDNA sequence.; ''J Biol Chem, 1998 - PubMed
  35. Hussein O, Rosenblat M, Refael G, Aviram M; ''Dietary selenium increases cellular glutathione peroxidase activity and reduces the enhanced susceptibility to lipid peroxidation of plasma and low-density lipoprotein in kidney transplant recipients.; ''Transplantation, 1997 - PubMed
  36. Schumm K, Rocha S, Caamano J, Perkins ND; ''Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit.; ''EMBO J, 2006 - PubMed
  37. Struys EA, Jansen EE, de Meer K, Jakobs C; ''Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry.; ''Clin Chem, 2000 - PubMed
  38. Peters KL, Smith HL, Stark GR, Sen GC; ''IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNA.; ''Proc Natl Acad Sci U S A, 2002 - PubMed
  39. White BA, Cacciapuoti AF, Fricke RJ, Whitehead TR, Mosbach EH, Hylemon PB; ''Cofactor requiremets for 7 alpha-dehydroxylation of cholic and chenodeoxycholic acid in cell extracts of the intestinal anaerobic bacterium, Eubacterium species V.P.I. 13708.; ''J Lipid Res, 1981 - PubMed
  40. Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, Zick Y; ''A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation.; ''J Biol Chem, 1997 - PubMed
  41. Stoffel W, LeKim D, Sticht G; ''Metabolism of sphingosine bases. 8. Distribution, isolation and properties of D-3-oxosphinganine reductase. Stereospecificity of the NADPH-dependent reaction of 3-oxodihydrospingosine (2-amino-1-hydroxyoctadecane-3-one).; ''Hoppe Seylers Z Physiol Chem, 1968 - PubMed
  42. van der Westhuyzen DR, Cai L, de Beer MC, de Beer FC; ''Serum amyloid A promotes cholesterol efflux mediated by scavenger receptor B-I.; ''J Biol Chem, 2005 - PubMed
  43. Isseroff RR, Ziboh VA, Chapkin RS, Martinez DT; ''; '', - PubMed
  44. Schwarz M, Wright AC, Davis DL, Nazer H, Björkhem I, Russell DW; ''The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis.; ''J Clin Invest, 2000 - PubMed
  45. Watanabe K; ''Prostaglandin F synthase.; ''Prostaglandins Other Lipid Mediat, 2002 - PubMed
  46. Hoey L, Strain JJ, McNulty H; ''Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.; ''Am J Clin Nutr, 2009 - PubMed
  47. Agaugué S, Perrin-Cocon L, Coutant F, André P, Lotteau V; ''1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity.; ''J Immunol, 2006 - PubMed
  48. Minkes M, Stanford N, Chi MM, Roth GJ, Raz A, Needleman P, Majerus PW; ''Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions.; ''J Clin Invest, 1977 - PubMed
  49. Yun J, Kim JY, Kim OY, Jang Y, Chae JS, Kwak JH, Lim HH, Park HY, Lee SH, Lee JH; ''Associations of plasma homocysteine level with brachial-ankle pulse wave velocity, LDL atherogenicity, and inflammation profile in healthy men.; ''Nutr Metab Cardiovasc Dis, 2009 - PubMed
  50. Lewis GF, Rader DJ; ''New insights into the regulation of HDL metabolism and reverse cholesterol transport.; ''Circ Res, 2005 - PubMed
  51. Hahn FM, Xuan JW, Chambers AF, Poulter CD; ''Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization.; ''Arch Biochem Biophys, 1996 - PubMed
  52. Brigelius-Flohé R; ''Tissue-specific functions of individual glutathione peroxidases.; ''Free Radic Biol Med, 1999 - PubMed
  53. Schaap D, de Widt J, van der Wal J, Vandekerckhove J, van Damme J, Gussow D, Ploegh HL, van Blitterswijk WJ, van der Bend RL; ''Purification, cDNA-cloning and expression of human diacylglycerol kinase.; ''FEBS Lett, 1990 - PubMed
  54. Whanger PD; ''Selenoprotein expression and function-Selenoprotein W.; ''Biochim Biophys Acta, 2009 - PubMed
  55. Bailey SW, Ayling JE; ''The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake.; ''Proc Natl Acad Sci U S A, 2009 - PubMed
  56. Johnson KR, Johnson KY, Becker KP, Bielawski J, Mao C, Obeid LM; ''Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability.; ''J Biol Chem, 2003 - PubMed
  57. Borzutzky A, Crompton B, Bergmann AK, Giliani S, Baxi S, Martin M, Neufeld EJ, Notarangelo LD; ''Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter.; ''Clin Immunol, 2009 - PubMed
  58. Nakamura MT, Nara TY; ''Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases.; ''Annu Rev Nutr, 2004 - PubMed
  59. Skacel N, Menon LG, Mishra PJ, Peters R, Banerjee D, Bertino JR, Abali EE; ''Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment.; ''J Biol Chem, 2005 - PubMed
  60. Johnson MR, Barnes S, Diasio RB; ''Radioassay of bile acid coenzyme A:glycine/taurine: N-acyltransferase using an n-butanol solvent extraction procedure.; ''Anal Biochem, 1989 - PubMed
  61. Gao Y, Hannan NR, Wanyonyi S, Konstantopolous N, Pagnon J, Feng HC, Jowett JB, Kim KH, Walder K, Collier GR; ''Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells.; ''Cytokine, 2006 - PubMed
  62. Hesse-Bähr K, Dreher I, Köhrle J; ''The influence of the cytokines Il-1beta and INFgamma on the expression of selenoproteins in the human hepatocarcinoma cell line HepG2.; ''Biofactors, 2000 - PubMed
  63. Jiang LL, Kurosawa T, Sato M, Suzuki Y, Hashimoto T; ''Physiological role of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein.; ''J Biochem, 1997 - PubMed
  64. Lu B, Xu FY, Jiang YJ, Choy PC, Hatch GM, Grunfeld C, Feingold KR; ''Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1).; ''J Lipid Res, 2006 - PubMed
  65. Helgerud P, Saarem K, Norum KR; ''Acyl-CoA:cholesterol acyltransferase in human small intestine: its activity and some properties of the enzymic reaction.; ''J Lipid Res, 1981 - PubMed
  66. Pedretti A, Bocci E, Maggi R, Vistoli G; ''Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations.; ''Steroids, 2008 - PubMed
  67. Moreno JJ; ''New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.; ''Biochem Pharmacol, 2009 - PubMed
  68. Lavie CJ, Milani RV, Mehra MR, Ventura HO; ''Omega-3 polyunsaturated fatty acids and cardiovascular diseases.; ''J Am Coll Cardiol, 2009 - PubMed
  69. Vásquez-Vivar J; ''Tetrahydrobiopterin, superoxide, and vascular dysfunction.; ''Free Radic Biol Med, 2009 - PubMed
  70. Faust JR, Goldstein JL, Brown MS; ''Squalene synthetase activity in human fibroblasts: regulation via the low density lipoprotein receptor.; ''Proc Natl Acad Sci U S A, 1979 - PubMed
  71. Sica A, Tan TH, Rice N, Kretzschmar M, Ghosh P, Young HA; ''The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element.; ''Proc Natl Acad Sci U S A, 1992 - PubMed
  72. Horrobin DF; ''Fatty acid metabolism in health and disease: the role of delta-6-desaturase.; ''Am J Clin Nutr, 1993 - PubMed
  73. Liu YY, Han TY, Giuliano AE, Cabot MC; ''Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells.; ''J Biol Chem, 1999 - PubMed
  74. Engels F, Nijkamp FP; ''Pharmacological inhibition of leukotriene actions.; ''Pharm World Sci, 1998 - PubMed
  75. May JM, Mendiratta S, Hill KE, Burk RF; ''Reduction of dehydroascorbate to ascorbate by the selenoenzyme thioredoxin reductase.; ''J Biol Chem, 1997 - PubMed
  76. Ahlberg J, Angelin B, Björkhem I, Einarsson K, Leijd B; ''Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones.; ''J Lipid Res, 1979 - PubMed
  77. Smith WL; ''Cyclooxygenases, peroxide tone and the allure of fish oil.; ''Curr Opin Cell Biol, 2005 - PubMed
  78. Paradisi G, Cucinelli F, Mele MC, Barini A, Lanzone A, Caruso A; ''Endothelial function in post-menopausal women: effect of folic acid supplementation.; ''Hum Reprod, 2004 - PubMed
  79. Kalpakcioglu B, Senel K; ''The interrelation of glutathione reductase, catalase, glutathione peroxidase, superoxide dismutase, and glucose-6-phosphate in the pathogenesis of rheumatoid arthritis.; ''Clin Rheumatol, 2008 - PubMed
  80. Grumolato L, Ghzili H, Montero-Hadjadje M, Gasman S, Lesage J, Tanguy Y, Galas L, Ait-Ali D, Leprince J, Guérineau NC, Elkahloun AG, Fournier A, Vieau D, Vaudry H, Anouar Y; ''Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion.; ''FASEB J, 2008 - PubMed
  81. Bailey JM, Bryant RW, Whiting J, Salata K; ''Characterization of 11-HETE and 15-HETE, together with prostacyclin, as major products of the cyclooxygenase pathway in cultured rat aorta smooth muscle cells.; ''J Lipid Res, 1983 - PubMed
  82. Huijghebaert SM, Hofmann AF; ''Influence of the amino acid moiety on deconjugation of bile acid amidates by cholylglycine hydrolase or human fecal cultures.; ''J Lipid Res, 1986 - PubMed
  83. Hoey L, Strain JJ, McNulty H; ''Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.; ''Am J Clin Nutr, 2009 - PubMed
  84. Cuebas DA, Phillips C, Schmitz W, Conzelmann E, Novikov DK; ''The role of alpha-methylacyl-CoA racemase in bile acid synthesis.; ''Biochem J, 2002 - PubMed
  85. Collart MA, Baeuerle P, Vassalli P; ''Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B.; ''Mol Cell Biol, 1990 - PubMed
  86. Setty BN, Stuart MJ, Walenga RW; ''Formation of 11-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid in human umbilical arteries is catalyzed by cyclooxygenase.; ''Biochim Biophys Acta, 1985 - PubMed
  87. Kraveka JM, Li L, Szulc ZM, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Bielawska A; ''Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.; ''J Biol Chem, 2007 - PubMed
  88. Bakovic M, Fullerton MD, Michel V; ''Metabolic and molecular aspects of ethanolamine phospholipid biosynthesis: the role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2).; ''Biochem Cell Biol, 2007 - PubMed
  89. Selhub J.; ''Homocysteine metabolism.; ''Annu Rev Nutr, 1999 - PubMed
  90. Schöneich C; ''Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease.; ''Biochim Biophys Acta, 2005 - PubMed
  91. Feng Q, Keshtgarpour M, Pelleymounter LL, Moon I, Kalari KR, Eckloff BW, Wieben ED, Weinshilboum RM; ''Human S-adenosylhomocysteine hydrolase: common gene sequence variation and functional genomic characterization.; ''J Neurochem, 2009 - PubMed
  92. Molnar J, Garamvolgyi Z, Herold M, Adanyi N, Somogyi A, Rigo J Jr; ''Serum selenium concentrations correlate significantly with inflammatory biomarker high-sensitive CRP levels in Hungarian gestational diabetic and healthy pregnant women at mid-pregnancy.; ''Biol Trace Elem Res, 2008 - PubMed
  93. Jakubowski H; ''Molecular basis of homocysteine toxicity in humans.; ''Cell Mol Life Sci, 2004 - PubMed
  94. Inoue T, Irikura D, Okazaki N, Kinugasa S, Matsumura H, Uodome N, Yamamoto M, Kumasaka T, Miyano M, Kai Y, Urade Y; ''Mechanism of metal activation of human hematopoietic prostaglandin D synthase.; ''Nat Struct Biol, 2003 - PubMed
  95. http://lpi.oregonstate.edu/infocenter/vitamins/fa/; ''Folic acid; ''Linus Pauling Institute,
  96. Ghosh J, Myers CE; ''Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells.; ''Proc Natl Acad Sci U S A, 1998 - PubMed
  97. Deo AK, Bandiera SM; ''Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid.; ''Drug Metab Dispos, 2008 - PubMed
  98. Sandrine A, Ferreiro A; ''Selenoproteins and protection against oxidative stress: selenoprotein N as a novel player at the crossroads of redox signalling and calcium homeostasis.; ''Antioxid Redox Signal, 2009 - PubMed
  99. Ferré P; ''The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity.; ''Diabetes, 2004 - PubMed
  100. Yamaoka S, Miyaji M, Kitano T, Umehara H, Okazaki T; ''Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells.; ''J Biol Chem, 2004 - PubMed
  101. Schnedl WJ, Liebminger A, Roller RE, Lipp RW, Krejs GJ; ''; '', - PubMed
  102. Joensen AM, Schmidt EB, Dethlefsen C, Johnsen SP, Tjønneland A, Rasmussen LH, Overvad K; ''Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome - a cohort study.; ''Br J Nutr, 2009 - PubMed
  103. Lucock M, Daskalakis I, Briggs D, Yates Z, Levene M; ''Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: influence of 677c -->t methylenetetrahydrofolate reductase and 2756a -->g methionine synthase genotypes.; ''Mol Genet Metab, 2000 - PubMed
  104. Eklund CM; ''Proinflammatory cytokines in CRP baseline regulation.; ''Adv Clin Chem, 2009 - PubMed
  105. Hammarström S; ''Leukotrienes.; ''Annu Rev Biochem, 1983 - PubMed
  106. Leclerc D, Campeau E, Goyette P, Adjalla CE, Christensen B, Ross M, Eydoux P, Rosenblatt DS, Rozen R, Gravel RA.; ''Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders.; ''Hum Mol Genet., 1996 - PubMed
  107. Lee WH, Lukacik P, Guo K, Ugochukwu E, Kavanagh KL, Marsden B, Oppermann U; ''Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.; ''Mol Cell Endocrinol, 2008 - PubMed
  108. Baker CH, Matsuda SP, Liu DR, Corey EJ; ''Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library.; ''Biochem Biophys Res Commun, 1995 - PubMed
  109. Salem N Jr, Pawlosky R, Wegher B, Hibbeln J; ''In vivo conversion of linoleic acid to arachidonic acid in human adults.; ''Prostaglandins Leukot Essent Fatty Acids, 1999 - PubMed
  110. Ho AW, Wong CK, Lam CW; ''Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways.; ''Immunobiology, 2008 - PubMed
  111. Itabe H; ''Oxidative modification of LDL: its pathological role in atherosclerosis.; ''Clin Rev Allergy Immunol, 2009 - PubMed
  112. Waterham HR, Wijburg FA, Hennekam RC, Vreken P, Poll-The BT, Dorland L, Duran M, Jira PE, Smeitink JA, Wevers RA, Wanders RJ; ''Smith-Lemli-Opitz syndrome is caused by mutations in the 7-dehydrocholesterol reductase gene.; ''Am J Hum Genet, 1998 - PubMed
  113. Draus E, Niefind J, Vietor K, Havsteen B; ''Isolation and characterization of the human liver ethanolamine kinase.; ''Biochim Biophys Acta, 1990 - PubMed
  114. Cheng JB, Jacquemin E, Gerhardt M, Nazer H, Cresteil D, Heubi JE, Setchell KD, Russell DW; ''Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease.; ''J Clin Endocrinol Metab, 2003 - PubMed
  115. Petersen Shay K, Moreau RF, Smith EJ, Hagen TM.; ''Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity.; ''IUBMB Life., 2008 - PubMed
  116. Chatterjee S, Castiglione E; ''UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes.; ''Biochim Biophys Acta, 1987 - PubMed
  117. Hasan UA, Caux C, Perrot I, Doffin AC, Menetrier-Caux C, Trinchieri G, Tommasino M, Vlach J; ''Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs.; ''Proc Natl Acad Sci U S A, 2007 - PubMed
  118. Wilson A, Leclerc D, Rosenblatt DS, Gravel RA; ''Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism.; ''Hum Mol Genet, 1999 - PubMed
  119. Pikuleva IA, Puchkaev A, Björkhem I; ''Putative helix F contributes to regioselectivity of hydroxylation in mitochondrial cytochrome P450 27A1.; ''Biochemistry, 2001 - PubMed
  120. Scheurig AC, Thorand B, Fischer B, Heier M, Koenig W; ''Association between the intake of vitamins and trace elements from supplements and C-reactive protein: results of the MONICA/KORA Augsburg study.; ''Eur J Clin Nutr, 2008 - PubMed
  121. Son YH, Jeong YT, Lee KA, Choi KH, Kim SM, Rhim BY, Kim K; ''Roles of MAPK and NF-kappaB in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells.; ''J Cardiovasc Pharmacol, 2008 - PubMed
  122. Kim YI; ''Role of the MTHFR polymorphisms in cancer risk modification and treatment.; ''Future Oncol, 2009 - PubMed
  123. ''Food and Nutrition Board, Institute of Medicine. Vitamin B6. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Vitamin B12, Pantothenic Acid, Biotin, and Choline.; ''Washington D.C.: National Academies Press, 1998
  124. Leclerc D, Wilson A, Dumas R, Gafuik C, Song D, Watkins D, Heng HH, Rommens JM, Scherer SW, Rosenblatt DS, Gravel RA; ''Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria.; ''Proc Natl Acad Sci U S A, 1998 - PubMed
  125. Yang P, Chan D, Felix E, Cartwright C, Menter DG, Madden T, Klein RD, Fischer SM, Newman RA; ''Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells.; ''J Lipid Res, 2004 - PubMed
  126. Weisel JW; ''Fibrinogen and fibrin.; ''Adv Protein Chem, 2005 - PubMed
  127. Tomohiro S, Kawaguti A, Kawabe Y, Kitada S, Kuge O; ''Purification and characterization of human phosphatidylserine synthase 1 and 2.; ''Biochem J, 2008 - PubMed
  128. Steinbrenner H, Sies H; ''Protection against reactive oxygen species by selenoproteins.; ''Biochim Biophys Acta, 2009 - PubMed
  129. Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, Yang H, Gravel RA, Rozen R; ''A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida.; ''Molecular genetics and metabolism, 1999 - PubMed
  130. Peters-Golden M, Brock TG; ''5-lipoxygenase and FLAP.; ''Prostaglandins Leukot Essent Fatty Acids, 2003 - PubMed
  131. Jeong D, Kim TS, Chung YW, Lee BJ, Kim IY; ''Selenoprotein W is a glutathione-dependent antioxidant in vivo.; ''FEBS Lett, 2002 - PubMed
  132. Becker BF; ''Towards the physiological function of uric acid.; ''Free Radic Biol Med, 1993 - PubMed
  133. Izzo AA, Piscitelli F, Capasso R, Marini P, Cristino L, Petrosino S, Di Marzo V; ''Basal and Fasting/Refeeding-regulated Tissue Levels of Endogenous PPAR-alpha Ligands in Zucker Rats.; ''Obesity (Silver Spring), 2009 - PubMed
  134. Mamalakis G, Kafatos A, Tornaritis M, Alevizos B; ''Anxiety and adipose essential fatty acid precursors for prostaglandin E1 and E2.; ''J Am Coll Nutr, 1998 - PubMed
  135. Lu J, Holmgren A; ''Selenoproteins.; ''J Biol Chem, 2009 - PubMed
  136. Bates CJ, Thane CW, Prentice A, Delves HT; ''Selenium status and its correlates in a British national diet and nutrition survey: people aged 65 years and over.; ''J Trace Elem Med Biol, 2002 - PubMed
  137. Semnani RT, Venugopal PG, Leifer CA, Mostbˆck S, Sabzevari H, Nutman TB; ''Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites.; ''Blood, 2008 - PubMed
  138. Lijnen HR; ''Elements of the fibrinolytic system.; ''Ann N Y Acad Sci, 2001 - PubMed
  139. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone; ''Prostaglandins., 1982 - PubMed
  140. Gustafsson J; ''Bile acid synthesis during development. Mitochondrial 12 alpha-hydroxylation in human fetal liver.; ''J Clin Invest, 1985 - PubMed
  141. Karpe F, Bickerton AS, Hodson L, Fielding BA, Tan GD, Frayn KN; ''Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation.; ''Biochem Soc Trans, 2007 - PubMed
  142. Shimojo T, Akino T, Miura Y, Schroepfer GJ Jr; ''Sphingolipid base metabolism. Stereospecific uptake of proton in the enzymatic conversion of sphinganine 1-phosphate to ethanolamine 1-phosphate.; ''J Biol Chem, 1976 - PubMed
  143. Janciauskiene S, Wright HT; ''Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease.; ''Bioessays, 1998 - PubMed
  144. Spassieva S, Seo JG, Jiang JC, Bielawski J, Alvarez-Vasquez F, Jazwinski SM, Hannun YA, Obeid LM; ''; '', - PubMed
  145. Wu D, Mura C, Beharka AA, Han SN, Paulson KE, Hwang D, Meydani SN; ''Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E.; ''Am J Physiol, 1998 - PubMed
  146. Paul P, Kamisaka Y, Marks DL, Pagano RE; ''Purification and characterization of UDP-glucose:ceramide glucosyltransferase from rat liver Golgi membranes.; ''J Biol Chem, 1996 - PubMed
  147. Kilpatrick L, Johnson JL, Nickbarg EB, Wang ZM, Clifford TF, Banach M, Cooperman BS, Douglas SD, Rubin H; ''Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin.; ''J Immunol, 1991 - PubMed
  148. Kovacs E; ''The serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble gp130 (sgp130) in different tumour stages. Correlation between the two parameters in progression of malignancy.; ''Biomed Pharmacother, 2005 - PubMed
  149. Witkowska AM, Kuryliszyn-Moskal A, Borawska MH, Hukałowicz K, Markiewicz R; ''A study on soluble intercellular adhesion molecule-1 and selenium in patients with rheumatoid arthritis complicated by vasculitis.; ''Clin Rheumatol, 2003 - PubMed
  150. Powis G, Montfort WR; ''Properties and biological activities of thioredoxins.; ''Annu Rev Pharmacol Toxicol, 2001 - PubMed
  151. Waterham HR, Koster J, Romeijn GJ, Hennekam RC, Vreken P, Andersson HC, FitzPatrick DR, Kelley RI, Wanders RJ; ''Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis.; ''Am J Hum Genet, 2001 - PubMed
  152. Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ; ''Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain.; ''J Biol Chem, 1997 - PubMed
  153. Janciauskiene S, Wright HT; ''Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease.; ''Bioessays, 1998 - PubMed
  154. Bose R, Kolesnick R; ''Measurement of ceramide synthase activity.; ''Methods Enzymol, 2000 - PubMed
  155. Voelker DR; ''Phosphatidylserine decarboxylase.; ''Biochim Biophys Acta, 1997 - PubMed
  156. Araya Z, Wikvall K; ''6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes.; ''Biochim Biophys Acta, 1999 - PubMed
  157. Proctor PH.; ''Free radicals, uric acid, and human disease.; ''Free Radic Biol Med., 1996 - PubMed
  158. Bierbach H; ''Studies on long chain fatty acid:CoA ligase from human small intestine.; ''Gut, 1980 - PubMed
  159. Guzik TJ, Korbut R, Adamek-Guzik T.; ''Nitric oxide and superoxide in inflammation and immune regulation.; ''J Physiol Pharmacol., 2003 - PubMed
  160. Puig-Kröger A, Sierra-Filardi E, Domínguez-Soto A, Samaniego R, Corcuera MT, Gómez-Aguado F, Ratnam M, Sánchez-Mateos P, Corbí AL; ''Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages.; ''Cancer Res, 2009 - PubMed
  161. Levin G, Duffin KL, Obukowicz MG, Hummert SL, Fujiwara H, Needleman P, Raz A; ''Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2.; ''Biochem J, 2002 - PubMed
  162. Basu S; ''F2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications.; ''Antioxid Redox Signal, 2008 - PubMed
  163. Galton DJ; ''Lipogenesis in human adipose tissue.; ''J Lipid Res, 1968 - PubMed
  164. Guzik TJ, Korbut R, Adamek-Guzik T.; ''Nitric oxide and superoxide in inflammation and immune regulation.; ''J Physiol Pharmacol., 2003 - PubMed
  165. Fernandes-Costa F: Metz J.; ''Vitamin B12 binders (transcobalamins) in serum.; ''Crit Rev Clin Lab Sci., 1982 - PubMed
  166. Guzik TJ, Korbut R, Adamek-Guzik T; ''Nitric oxide and superoxide in inflammation and immune regulation.; ''J Physiol Pharmacol, 2003 - PubMed
  167. Selhub J.; ''Homocysteine metabolism.; ''Annu Rev Nutr., 1999 - PubMed
  168. Kimura M, Okuno E, Inada J, Ohyama H, Kido R; ''Purification and characterization of amino-acid N-choloyltransferase from human liver.; ''Hoppe Seylers Z Physiol Chem, 1983 - PubMed
  169. Yamauchi Y, Reid PC, Sperry JB, Furukawa K, Takeya M, Chang CC, Chang TY; ''Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols.; ''J Biol Chem, 2007 - PubMed
  170. Jakobsson A, Westerberg R, Jacobsson A; ''Fatty acid elongases in mammals: their regulation and roles in metabolism.; ''Prog Lipid Res, 2006 - PubMed
  171. Korotkov KV, Novoselov SV, Hatfield DL, Gladyshev VN; ''Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element.; ''Mol Cell Biol, 2002 - PubMed
  172. Laden BP, Tang Y, Porter TD; ''Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase.; ''Arch Biochem Biophys, 2000 - PubMed
  173. Panee J, Stoytcheva ZR, Liu W, Berry MJ; ''; '', - PubMed
  174. Nava VE, Lacana E, Poulton S, Liu H, Sugiura M, Kono K, Milstien S, Kohama T, Spiegel S; ''Functional characterization of human sphingosine kinase-1.; ''FEBS Lett, 2000 - PubMed
  175. Banning A, Florian S, Deubel S, Thalmann S, Müller-Schmehl K, Jacobasch G, Brigelius-Flohé R; ''GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells.; ''Antioxid Redox Signal, 2008 - PubMed
  176. Abu-Soud HM, Hazen SL; ''Nitric oxide is a physiological substrate for mammalian peroxidases.; ''J Biol Chem, 2000 - PubMed
  177. Leung DW, Tompkins CK, White T; ''Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells.; ''DNA Cell Biol, 1998 - PubMed
  178. Burk RF, Hill KE, Motley AK; ''Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P.; ''J Nutr, 2003 - PubMed
  179. Ben van Ommen, Susan Fairweather-Tait, Andreas Freidig, Alwine Kardinaal, Augustin Scalbert, Suzan Wopereis; ''A network biology model of micronutrient related health; ''Br J Nutr, 2008
  180. Bjørke Monsen AL, Ueland PM, Vollset SE, Guttormsen AB, Markestad T, Solheim E, Refsum H; ''Determinants of cobalamin status in newborns.; ''Pediatrics, 2001 - PubMed
  181. Marnett LJ; ''Lipid peroxidation-DNA damage by malondialdehyde.; ''Mutat Res, 1999 - PubMed
  182. Youssef D, El Abbassi A, Jordan RM, Peiris AN; ''Fructosamine--an underutilized tool in diabetes management: case report and literature review.; ''Tenn Med, 2008 - PubMed
  183. Heirman I, Ginneberge D, Brigelius-Flohé R, Hendrickx N, Agostinis P, Brouckaert P, Rottiers P, Grooten J; ''Blocking tumor cell eicosanoid synthesis by GP x 4 impedes tumor growth and malignancy.; ''Free Radic Biol Med, 2006 - PubMed
  184. Herbert V; ''Vitamin B-12: plant sources, requirements, and assay.; ''Am J Clin Nutr, 1988 - PubMed
  185. Ben Jilani KE, Panee J, He Q, Berry MJ, Li PA; ''Overexpression of selenoprotein H reduces Ht22 neuronal cell death after UVB irradiation by preventing superoxide formation.; ''Int J Biol Sci, 2007 - PubMed
  186. WikiPathways; ''Selenoproteins; ''http://www.wikipathways.org/index.php/Pathway:Homo_sapiens:Selenoproteins,
  187. Johnson J, Albarani V, Nguyen M, Goldman M, Willems F, Aksoy E; ''Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis.; ''J Biol Chem, 2007 - PubMed
  188. Aksoy E, Vanden Berghe W, Detienne S, Amraoui Z, Fitzgerald KA, Haegeman G, Goldman M, Willems F; ''Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4.; ''Eur J Immunol, 2005 - PubMed
  189. Moore SA, Hurt E, Yoder E, Sprecher H, Spector AA; ''Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid.; ''J Lipid Res, 1995 - PubMed
  190. Cali JJ, Russell DW; ''Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.; ''J Biol Chem, 1991 - PubMed
  191. Hoyos B, Ballard DW, Böhnlein E, Siekevitz M, Greene WC; ''Kappa B-specific DNA binding proteins: role in the regulation of human interleukin-2 gene expression.; ''Science, 1989 - PubMed
  192. Zamocky M, Furtmüller PG, Obinger C; ''Evolution of catalases from bacteria to humans.; ''Antioxid Redox Signal, 2008 - PubMed
  193. Arbogast S, Beuvin M, Fraysse B, Zhou H, Muntoni F, Ferreiro A; ''Oxidative stress in SEPN1-related myopathy: from pathophysiology to treatment.; ''Ann Neurol, 2009 - PubMed
  194. https://analysis.ingenuity.com/; ''Arachidonic Acid Metabolism; ''Ingenuity sofware,
  195. Chen Y, Dennis EA; ''Expression and characterization of human group V phospholipase A2.; ''Biochim Biophys Acta, 1998 - PubMed
  196. Nitahara Y, Aoyama Y, Horiuchi T, Noshiro M, Yoshida Y; ''Purification and characterization of rat sterol 14-demethylase P450 (CYP51) expressed in Escherichia coli.; ''J Biochem, 1999 - PubMed
  197. Edmondson DE, Newton-Vinson P; ''The covalent FAD of monoamine oxidase: structural and functional role and mechanism of the flavinylation reaction.; ''Antioxid Redox Signal, 2001 - PubMed
  198. Kilpatrick L, Johnson JL, Nickbarg EB, Wang ZM, Clifford TF, Banach M, Cooperman BS, Douglas SD, Rubin H; ''Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin.; ''J Immunol, 1991 - PubMed
  199. Malle E, Marsche G, Arnhold J, Davies MJ; ''Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid.; ''Biochim Biophys Acta, 2006 - PubMed
  200. Nilsson A, Duan RD; ''Absorption and lipoprotein transport of sphingomyelin.; ''J Lipid Res, 2006 - PubMed
  201. Smith WL, Langenbach R; ''Why there are two cyclooxygenase isozymes.; ''J Clin Invest, 2001 - PubMed
  202. Köhrle J, Jakob F, Contempré B, Dumont JE; ''Selenium, the thyroid, and the endocrine system.; ''Endocr Rev, 2005 - PubMed
  203. Correa-Cerro LS, Porter FD; ''3beta-hydroxysterol Delta7-reductase and the Smith-Lemli-Opitz syndrome.; ''Mol Genet Metab, 2005 - PubMed
  204. McCay PB; ''Vitamin E: interactions with free radicals and ascorbate.; ''Annu Rev Nutr, 1985 - PubMed
  205. Hoey L, McNulty H, Strain JJ; ''Studies of biomarker responses to intervention with riboflavin: a systematic review.; ''Am J Clin Nutr, 2009 - PubMed
  206. Jackowski S, Fagone P; ''CTP: Phosphocholine cytidylyltransferase: paving the way from gene to membrane.; ''J Biol Chem, 2005 - PubMed
  207. Bosschaerts T, Guilliams M, Noel W, Hérin M, Burk RF, Hill KE, Brys L, Raes G, Ghassabeh GH, De Baetselier P, Beschin A; ''Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P.; ''J Immunol, 2008 - PubMed
  208. Yamashita S, Hosaka K, Numa S; ''Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes.; ''Eur J Biochem, 1973 - PubMed
  209. Shields DJ, Lehner R, Agellon LB, Vance DE; ''Membrane topography of human phosphatidylethanolamine N-methyltransferase.; ''J Biol Chem, 2003 - PubMed
  210. Shchedrina VA, Zhang Y, Labunskyy VM, Hatfield DL, Gladyshev V; ''Structure-function relationships, physiological roles and evolution of mammalian ER-resident selenoproteins.; ''Antioxid Redox Signal, 2009 - PubMed
  211. Bates CJ, Thane CW, Prentice A, Delves HT; ''Selenium status and its correlates in a British national diet and nutrition survey: people aged 65 years and over.; ''J Trace Elem Med Biol, 2002 - PubMed
  212. Okuma M, Yamashita S, Numa S; ''Enzymic studies on phosphatidic acid synthesis in human platelets.; ''Blood, 1973 - PubMed
  213. Singh S, Madzelan P, Banerjee R; ''Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase.; ''Nat Prod Rep, 2007 - PubMed
  214. Galijasevic S, Saed GM, Hazen SL, Abu-Soud HM; ''Myeloperoxidase metabolizes thiocyanate in a reaction driven by nitric oxide.; ''Biochemistry, 2006 - PubMed
  215. Bai YP, Liu YH, Chen J, Song T, You Y, Tang ZY, Li YJ, Zhang GG; ''Rosiglitazone attenuates NF-kappaB-dependent ICAM-1 and TNF-alpha production caused by homocysteine via inhibiting ERK1/2/p38MAPK activation.; ''Biochem Biophys Res Commun, 2007 - PubMed
  216. Momoi T, Ben-Yoseph Y, Nadler HL; ''Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with Farber disease and controls.; ''Biochem J, 1982 - PubMed
  217. Hammons AL, Summers CM, Woodside JV, McNulty H, Strain JJ, Young IS, Murray L, Boreham CA, Scott JM, Mitchell LE, Whitehead AS; ''Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1.; ''Clin Immunol, 2009 - PubMed
  218. Baumruker T, Bornancin F, Billich A; ''The role of sphingosine and ceramide kinases in inflammatory responses.; ''Immunol Lett, 2005 - PubMed
  219. Pyne S, Pyne NJ; ''Sphingosine 1-phosphate signalling in mammalian cells.; ''Biochem J, 2000 - PubMed
  220. Finkelstein JD; ''The metabolism of homocysteine: pathways and regulation.; ''Eur J Pediatr, 1998 - PubMed
  221. Gautier G, Humbert M, Deauvieau F, Scuiller M, Hiscott J, Bates EE, Trinchieri G, Caux C, Garrone P; ''A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.; ''J Exp Med, 2005 - PubMed
  222. Abate A, Yang G, Dennery PA, Oberle S, Schröder H; ''Synergistic inhibition of cyclooxygenase-2 expression by vitamin E and aspirin.; ''Free Radic Biol Med, 2000 - PubMed
  223. Leonard S, Arbogast D, Geyer D, Jones C, Sinensky M; ''Localization of the gene encoding 3-hydroxy-3-methylglutaryl-coenzyme A synthase to human chromosome 5.; ''Proc Natl Acad Sci U S A, 1986 - PubMed
  224. Al-Obaidi MK, Philippou H, Stubbs PJ, Adami A, Amersey R, Noble MM, Lane DA; ''Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes.; ''Circulation, 2000 - PubMed
  225. Manieri W, Moore ME, Soellner MB, Tsang P, Caperelli CA; ''Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes.; ''Biochemistry, 2007 - PubMed
  226. Franken PA, Van den Berg L, Huang J, Gunyuzlu P, Lugtigheid RB, Verheij HM, De Haas GH; ''Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli. Cleavage of a fusion protein with cyanogen bromide.; ''Eur J Biochem, 1992 - PubMed
  227. Remoli ME, Ragimbeau J, Giacomini E, Gafa V, Severa M, Lande R, Pellegrini S, Coccia EM; ''NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation.; ''J Leukoc Biol, 2007 - PubMed
  228. Bleys J, Navas-Acien A, Guallar E; ''Serum selenium and diabetes in U.S. adults.; ''Diabetes Care, 2007 - PubMed
  229. Eberhardt C, Gray PW, Tjoelker LW; ''Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3.; ''J Biol Chem, 1997 - PubMed
  230. Saavedra WF, Paolocci N, St John ME, Skaf MW, Stewart GC, Xie JS, Harrison RW, Zeichner J, Mudrick D, Marbán E, Kass DA, Hare JM; ''Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart.; ''Circ Res, 2002 - PubMed
  231. Maccarrone M, Meloni C, Manca-di-Villahermosa S, Cococcetta N, Casciani CU, Finazzi-Agrò A, Taccone-Gallucci M; ''Vitamin E suppresses 5-lipoxygenase-mediated oxidative stress in peripheral blood mononuclear cells of hemodialysis patients regardless of administration route.; ''Am J Kidney Dis, 2001 - PubMed
  232. Olivier LM, Chambliss KL, Gibson KM, Krisans SK; ''Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting.; ''J Lipid Res, 1999 - PubMed
  233. Penning TM, Jin Y, Steckelbroeck S, Lanisnik Rizner T, Lewis M; ''Structure-function of human 3 alpha-hydroxysteroid dehydrogenases: genes and proteins.; ''Mol Cell Endocrinol, 2004 - PubMed
  234. Fowler B.; ''Homocysteine: overview of biochemistry, molecular biology, and role in disease processes.; ''Semin Vasc Med, 2005 - PubMed
  235. Johnsen IB, Nguyen TT, Ringdal M, Tryggestad AM, Bakke O, Lien E, Espevik T, Anthonsen MW; ''Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling.; ''EMBO J, 2006 - PubMed
  236. Amaral JD, Castro RE, Steer CJ, Rodrigues CM; ''p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis.; ''Trends Mol Med, 2009 - PubMed
  237. Giera M, Renard D, Plössl F, Bracher F; ''Lathosterol side chain amides: a new class of human lathosterol oxidase inhibitors.; ''Steroids, 2008 - PubMed
  238. Lu C, Qiu F, Zhou H, Peng Yp, Hao W, Xu J, Yuan J, Wang S, Qiang B, Xu C, Peng X.; ''Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes.; ''FEBS Lett., 2006 - PubMed
  239. Zheng L, Nukuna B, Brennan ML, Sun M, Goormastic M, Settle M, Schmitt D, Fu X, Thomson L, Fox PL, Ischiropoulos H, Smith JD, Kinter M, Hazen SL; ''Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease.; ''J Clin Invest, 2004 - PubMed
  240. Serhan CN; ''Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity?; ''Prostaglandins, 1997 - PubMed
  241. Zhang C, Cai Y, Adachi MT, Oshiro S, Aso T, Kaufman RJ, Kitajima S; ''Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response.; ''J Biol Chem, 2001 - PubMed
  242. Evans P, Halliwell B; ''Free radicals and hearing. Cause, consequence, and criteria.; ''Ann N Y Acad Sci, 1999 - PubMed
  243. Needleman P, Raz A, Minkes MS, Ferrendelli JA, Sprecher H; ''Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties.; ''Proc Natl Acad Sci U S A, 1979 - PubMed
  244. Antonenkov VD, Van Veldhoven PP, Waelkens E, Mannaerts GP; ''Substrate specificities of 3-oxoacyl-CoA thiolase A and sterol carrier protein 2/3-oxoacyl-CoA thiolase purified from normal rat liver peroxisomes. Sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in the metabolism of 2-methyl-branched fatty acids and bile acid intermediates.; ''J Biol Chem, 1997 - PubMed
  245. Kwak SE, Kim JE, Kim DW, Kwon OS, Choi SY, Kang TC; ''Pyridoxine 5'-phosphate oxidase, not pyridoxal kinase, involves in long-term potentiation induction in the rat dentate gyrus.; ''Hippocampus, 2009 - PubMed
  246. Bohnenkamp HR, Papazisis KT, Burchell JM, Taylor-Papadimitriou J; ''Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses.; ''Cell Immunol, 2007 - PubMed
  247. Xie S, Wang Q, Wu H, Cogswell J, Lu L, Jhanwar-Uniyal M, Dai W; ''Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3.; ''J Biol Chem, 2001 - PubMed
  248. Reilly IA, FitzGerald GA; ''Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs.; ''Blood, 1987 - PubMed
  249. Erickson SK, Bösterling B; ''Cholesterol 7 alpha-hydroxylase from human liver: partial purification and reconstruction into defined phospholipid-cholesterol vesicles.; ''J Lipid Res, 1981 - PubMed
  250. Simmons DL, Botting RM, Hla T; ''Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition.; ''Pharmacol Rev, 2004 - PubMed
  251. https://analysis.ingenuity.com/; ''Prostaglandin and Leukotriene Metabolism; ''Ingenuity software,
  252. Lucock M; ''Folic acid: nutritional biochemistry, molecular biology, and role in disease processes.; ''Mol Genet Metab, 2000 - PubMed
  253. http://lpi.oregonstate.edu/infocenter/vitamins/vitaminB6/; ''Vitamin B 6; ''Linus Paulin institute,
  254. Kryukov GV, Kumar RA, Koc A, Sun Z, Gladyshev VN.; ''Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase.; ''Proc Natl Acad Sci U S A., 2002 - PubMed
  255. Hosaka K, Tanaka S, Nikawa J, Yamashita S; ''Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation.; ''FEBS Lett, 1992 - PubMed
  256. Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA; ''A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.; ''Nature, 2004 - PubMed
  257. Goldstein JL, Brown MS; ''Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol.; ''Proc Natl Acad Sci U S A, 1973 - PubMed
  258. Clifton PM, Mackinnon AM, Barter PJ; ''Effects of serum amyloid A protein (SAA) on composition, size, and density of high density lipoproteins in subjects with myocardial infarction.; ''J Lipid Res, 1985 - PubMed
  259. Bowser PA, Gray GM; ''Sphingomyelinase in pig and human epidermis.; ''J Invest Dermatol, 1978 - PubMed
  260. Abello N, Kerstjens HA, Postma DS, Bischoff R; ''Protein tyrosine nitration: selectivity, physicochemical and biological consequences, denitration, and proteomics methods for the identification of tyrosine-nitrated proteins.; ''J Proteome Res, 2009 - PubMed
  261. Schöneich C; ''Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease.; ''Biochim Biophys Acta, 2005 - PubMed
  262. Ogawa H, Gomi T, Fujioka M; ''Serine hydroxymethyltransferase and threonine aldolase: are they identical?; ''Int J Biochem Cell Biol, 2000 - PubMed
  263. Verrax J, Calderon PB; ''The controversial place of vitamin C in cancer treatment.; ''Biochem Pharmacol, 2008 - PubMed
  264. Schäfer M, Werner S; ''Oxidative stress in normal and impaired wound repair.; ''Pharmacol Res, 2008 - PubMed
  265. Ho TC, Chen SL, Yang YC, Chen CY, Feng FP, Hsieh JW, Cheng HC, Tsao YP; ''15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53.; ''J Biol Chem, 2008 - PubMed
  266. Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML.; ''Domain alternation switches B(12)-dependent methionine synthase to the activation conformation.; ''Nat Struct Biol., 2002 - PubMed
  267. Magni G, Amici A, Emanuelli M, Orsomando G, Raffaelli N, Ruggieri S; ''Enzymology of NAD+ homeostasis in man.; ''Cell Mol Life Sci, 2004 - PubMed
  268. Matsukura S, Kokubu F, Kurokawa M, Kawaguchi M, Ieki K, Kuga H, Odaka M, Suzuki S, Watanabe S, Takeuchi H, Kasama T, Adachi M; ''Synthetic double-stranded RNA induces multiple genes related to inflammation through Toll-like receptor 3 depending on NF-kappaB and/or IRF-3 in airway epithelial cells.; ''Clin Exp Allergy, 2006 - PubMed
  269. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN; ''Characterization of mammalian selenoproteomes.; ''Science, 2003 - PubMed
  270. Lund EG, Kerr TA, Sakai J, Li WP, Russell DW; ''cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism.; ''J Biol Chem, 1998 - PubMed
  271. Vladimir Kery, Loelle Poneleit, Jeffrey D. Meyer, Mark C. Manning, Jan P. Kraus; ''Binding of Pyridoxal 5'-Phosphate to the Heme Protein Human Cystathionine -Synthase; ''Biochemistry., 1998
  272. Barth E, Albuszies G, Baumgart K, Matejovic M, Wachter U, Vogt J, Radermacher P, Calzia E; ''Glucose metabolism and catecholamines.; ''Crit Care Med, 2007 - PubMed
  273. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone.; ''Prostaglandins., 1982 - PubMed
  274. Shigenaga MK, Gimeno CJ, Ames BN; ''Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.; ''Proc Natl Acad Sci U S A, 1989 - PubMed
  275. Bütikofer P, Yee MC, Schott MA, Lubin BH, Kuypers FA; ''Generation of phosphatidic acid during calcium-loading of human erythrocytes. Evidence for a phosphatidylcholine-hydrolyzing phospholipase D.; ''Eur J Biochem, 1993 - PubMed
  276. Traupe H, Has C; ''The Conradi-Hünermann-Happle syndrome is caused by mutations in the gene that encodes a 8- 7 sterol isomerase and is biochemically related to the CHILD syndrome.; ''Eur J Dermatol, 2000 - PubMed
  277. Huwyler J, Bürgin M, Zeugin T, Gut J; ''Transformation of 5-hydroperoxyeicosatetraenoic acid into dihydroxy- and cysteinyl-leukotrienes by rat hepatocytes: effects of glutathione.; ''Mol Pharmacol, 1991 - PubMed
  278. Doo YC, Han SJ, Park WJ, Kim SM, Choi SH, Cho GY, Hong KS, Han KR, Lee NH, Oh DJ, Ryu KH, Rhim CY, Lee KH, Lee Y; ''Associations between C-reactive protein and circulating cell adhesion molecules in patients with unstable angina undergoing coronary intervention and their clinical implication.; ''Clin Cardiol, 2005 - PubMed
  279. Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M; ''Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation.; ''Blood, 2006 - PubMed
  280. Pesch J, Brehm U, Staib C, Grummt F; ''Repression of interleukin-2 and interleukin-4 promoters by tumor suppressor protein p53.; ''J Interferon Cytokine Res, 1996 - PubMed
  281. ''; '',
  282. Dubois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van De Putte LB, Lipsky PE; ''Cyclooxygenase in biology and disease.; ''FASEB J, 1998 - PubMed
  283. Sala A, Voelkel N, Maclouf J, Murphy RC; ''Leukotriene E4 elimination and metabolism in normal human subjects.; ''J Biol Chem, 1990 - PubMed
  284. Stoffel W, LeKim D, Sticht G; ''; '', - PubMed
  285. Rampersaud GC, Kauwell GP, Bailey LB; ''Folate: a key to optimizing health and reducing disease risk in the elderly.; ''J Am Coll Nutr, 2003 - PubMed
  286. Betsholtz IH, Wikvall K; ''Cytochrome P450 CYP27-catalyzed oxidation of C27-steroid into C27-acid.; ''J Steroid Biochem Mol Biol, 1995 - PubMed
  287. Klebanoff SJ; ''Myeloperoxidase: friend and foe.; ''J Leukoc Biol, 2005 - PubMed
  288. Zhao R, Qiu A, Tsai E, Jansen M, Akabas MH, Goldman ID; ''The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.; ''Mol Pharmacol, 2008 - PubMed
  289. Needleman P, Raz A, Minkes MS, Ferrendelli JA, Sprecher H; ''Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties.; ''Proc Natl Acad Sci U S A, 1979 - PubMed
  290. MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV; ''Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms.; ''Appl Environ Microbiol, 1982 - PubMed
  291. Lykidis A, Wang J, Karim MA, Jackowski S; ''Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway.; ''J Biol Chem, 2001 - PubMed
  292. Cao S, Zhang X, Edwards JP, Mosser DM; ''NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages.; ''J Biol Chem, 2006 - PubMed
  293. Al-Obaidi MK, Philippou H, Stubbs PJ, Adami A, Amersey R, Noble MM, Lane DA; ''Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes.; ''Circulation, 2000 - PubMed
  294. Miyazaki M, Kanto T, Inoue M, Itose I, Miyatake H, Sakakibara M, Yakushijin T, Kakita N, Hiramatsu N, Takehara T, Kasahara A, Hayashi N; ''Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I.; ''J Med Virol, 2008 - PubMed
  295. Cipollone F, Cicolini G, Bucci M; ''Cyclooxygenase and prostaglandin synthases in atherosclerosis: recent insights and future perspectives.; ''Pharmacol Ther, 2008 - PubMed
  296. Basu S.; ''Isoprostanes: novel bioactive products of lipid peroxidation.; ''Free Radic Res., 2004 - PubMed
  297. Lööf L, Wengle B; ''Enzymatic sulphation of bile salts in human liver.; ''Biochim Biophys Acta, 1978 - PubMed
  298. Labunskyy VM, Hatfield DL, Gladyshev VN; ''The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum.; ''IUBMB Life, 2007 - PubMed
  299. Santhanam U, Ray A, Sehgal PB; ''Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.; ''Proc Natl Acad Sci U S A, 1991 - PubMed
  300. McKinley MC, McNulty H, McPartlin J, Strain JJ, Scott JM; ''Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status.; ''Eur J Clin Nutr, 2002 - PubMed
  301. Chen D, Zhang XY, Shi Y; ''Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria.; ''Biochem J, 2006 - PubMed
  302. Schafer BL, Bishop RW, Kratunis VJ, Kalinowski SS, Mosley ST, Gibson KM, Tanaka RD; ''Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria.; ''J Biol Chem, 1992 - PubMed
  303. Bertran N, Camps J, Fernandez-Ballart J, Arija V, Ferre N, Tous M, Simo D, Murphy MM, Vilella E, Joven J; ''Diet and lifestyle are associated with serum C-reactive protein concentrations in a population-based study.; ''J Lab Clin Med, 2005 - PubMed
  304. Imai H, Narashima K, Arai M, Sakamoto H, Chiba N, Nakagawa Y; ''Suppression of leukotriene formation in RBL-2H3 cells that overexpressed phospholipid hydroperoxide glutathione peroxidase.; ''J Biol Chem, 1998 - PubMed
  305. Taki T, Kanfer JN; ''Phospholipase D from rat brain.; ''Methods Enzymol, 1981 - PubMed
  306. Goetzl EJ, Sun FF; ''Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils.; ''J Exp Med, 1979 - PubMed
  307. Esmon CT; ''Does inflammation contribute to thrombotic events?; ''Haemostasis, 2000 - PubMed
  308. Arnér ES, Nordberg J, Holmgren A; ''Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase.; ''Biochem Biophys Res Commun, 1996 - PubMed
  309. Gao Y, Feng HC, Walder K, Bolton K, Sunderland T, Bishara N, Quick M, Kantham L, Collier GR; ''Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein.; ''FEBS Lett, 2004 - PubMed
  310. Singh U, Devaraj S, Jialal I.; ''Vitamin E, oxidative stress, and inflammation.; ''Annu Rev Nutr., 2005 - PubMed
  311. Guimarães MJ, Peterson D, Vicari A, Cocks BG, Copeland NG, Gilbert DJ, Jenkins NA, Ferrick DA, Kastelein RA, Bazan JF, Zlotnik A; ''Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism?; ''Proc Natl Acad Sci U S A, 1996 - PubMed
  312. Schnurr K, Belkner J, Ursini F, Schewe T, Kühn H; ''The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products.; ''J Biol Chem, 1996 - PubMed
  313. Malle E, Marsche G, Arnhold J, Davies MJ; ''Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid.; ''Biochim Biophys Acta, 2006 - PubMed
  314. Shen W, Stone K, Jales A, Leitenberg D, Ladisch S; ''Inhibition of TLR activation and up-regulation of IL-1R-associated kinase-M expression by exogenous gangliosides.; ''J Immunol, 2008 - PubMed
  315. Wu C, Bates SM; ''Should D-dimer testing be used to predict the risk of recurrence after discontinuation of anticoagulant therapy for a first unprovoked episode of venous thromboembolism?; ''Pol Arch Med Wewn, 2009 - PubMed
  316. Wang LH, Kulmacz RJ; ''Thromboxane synthase: structure and function of protein and gene.; ''Prostaglandins Other Lipid Mediat, 2002 - PubMed
  317. Hansel A, Heinemann SH, Hoshi T; ''Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation.; ''Biochim Biophys Acta, 2005 - PubMed
  318. Fang JY, Xiao SD, Zhu SS, Yuan JM, Qiu DK, Jiang SJ; ''Relationship of plasma folic acid and status of DNA methylation in human gastric cancer.; ''J Gastroenterol, 1997 - PubMed
  319. Karthikeyan S, Zhou Q, Osterman AL, Zhang H; ''Ligand binding-induced conformational changes in riboflavin kinase: structural basis for the ordered mechanism.; ''Biochemistry, 2003 - PubMed
  320. Ivanov A, Nash-Barboza S, Hinkis S, Caudill MA; ''Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted.; ''J Am Diet Assoc, 2009 - PubMed
  321. Videla LA, Rodrigo R, Araya J, Poniachik J; ''Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease.; ''Trends Mol Med, 2006 - PubMed
  322. Ellis E, Goodwin B, Abrahamsson A, Liddle C, Mode A, Rudling M, Bjorkhem I, Einarsson C; ''Bile acid synthesis in primary cultures of rat and human hepatocytes.; ''Hepatology, 1998 - PubMed
  323. Yasutomi M, Ohshima Y, Omata N, Yamada A, Iwasaki H, Urasaki Y, Mayumi M; ''Erythromycin differentially inhibits lipopolysaccharide- or poly(I:C)-induced but not peptidoglycan-induced activation of human monocyte-derived dendritic cells.; ''J Immunol, 2005 - PubMed
  324. Niwa Y, Sakane T, Ichikawa M, Kondo T, Taniguchi S; ''Phospholipid transmethylation and choline phosphotransferase in microsomal fraction of human diseased liver.; ''J Hepatol, 1986 - PubMed
  325. Papp LV, Lu J, Holmgren A, Khanna KK; ''From selenium to selenoproteins: synthesis, identity, and their role in human health.; ''Antioxid Redox Signal, 2007 - PubMed
  326. Traber MG; ''Vitamin E regulatory mechanisms.; ''Annu Rev Nutr, 2007 - PubMed
  327. Guan ZZ, Wang YN, Xiao KQ, Hu PS, Liu JL; ''Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease.; ''Neurochem Int, 1999 - PubMed
  328. Bianco AC, Kim BW; ''Deiodinases: implications of the local control of thyroid hormone action.; ''J Clin Invest, 2006 - PubMed
  329. Glickman JF, Schmid A; ''Farnesyl pyrophosphate synthase: real-time kinetics and inhibition by nitrogen-containing bisphosphonates in a scintillation assay.; ''Assay Drug Dev Technol, 2007 - PubMed
  330. Das UN; ''Folic acid says NO to vascular diseases.; ''Nutrition, 2003 - PubMed
  331. ''; '', - PubMed

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36515view12:55, 29 March 2010Damarizohdg
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36205view13:39, 8 March 2010Damarizf2 isopros
36204view13:37, 8 March 2010Damarizb12 can
36203view13:36, 8 March 2010Damarizb12
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35901view19:00, 19 February 2010Damarizsod3(2)
35900view18:58, 19 February 2010Damarizsod3
35899view18:50, 19 February 2010Damarizpai-1(2)
35898view18:48, 19 February 2010Damarizpai-1
35897view18:43, 19 February 2010Damariztpa(2)
35896view18:40, 19 February 2010Damarizplg(2)
35895view18:38, 19 February 2010Damarizplg
35894view18:33, 19 February 2010Damarizthrombin(2)
35893view18:28, 19 February 2010Damarizthrombin
35892view18:26, 19 February 2010Damarizfactor vii(2)
35891view18:18, 19 February 2010Damarizfactor vii
35890view18:10, 19 February 2010Damarizfibrinogen(2)
35889view18:08, 19 February 2010Damarizfibrinogen
35888view17:52, 19 February 2010Damarizfibrin-1(2)
35887view17:46, 19 February 2010Damarizfibrin
35886view17:44, 19 February 2010DamarizPeriodical save, work in progress
35885view17:17, 19 February 2010Damarizd-dimer(2)
35884view17:13, 19 February 2010Damarizd-dimer
35883view17:01, 19 February 2010DamarizPeriodical save, work in progress
35882view16:58, 19 February 2010Damarizcanc2
35881view16:57, 19 February 2010Damarizcanc1
35880view16:56, 19 February 2010Damariztpa
35879view16:53, 19 February 2010Damarizfructosamine
35878view16:52, 19 February 2010Damarizalb
35877view16:48, 19 February 2010Damarizins-glucose
35876view16:45, 19 February 2010Damarizapoa1(2)
35875view16:43, 19 February 2010Damarizapoa1
35874view16:36, 19 February 2010Damarizhdl-c(2)
35873view16:34, 19 February 2010Damarizhdl-c
35871view14:50, 19 February 2010Thomastest
35868view01:05, 19 February 2010KhanspersModified categories
35859view19:13, 18 February 2010AlexanderPicotest
35858view19:04, 18 February 2010AlexanderPicotest
35857view18:29, 18 February 2010Damarizcholesterol2
35856view18:19, 18 February 2010Damarizcholesterol
35854view15:17, 18 February 2010Damarizhdl2
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35852view15:07, 18 February 2010Damarizact2
35851view15:03, 18 February 2010Damarizact
35850view14:54, 18 February 2010Jildauextra
35849view12:21, 18 February 2010Damarizldl(2)
35848view12:01, 18 February 2010Damarizldl (2)
35847view11:55, 18 February 2010Damarizldl

Pathway Info

DataNodes

View all 147 DataNodes

Name Type Backpage Header Database reference
INSRProtein3643 (Entrez Gene)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
ABCA1Protein19 (Entrez Gene)
Protein
VLDL/APOBMetabolite39027 (ChEBI)
Thromboxane B2MetaboliteHMDB03252 (HMDB)
NO2Metabolite33101 (ChEBI)
SLC19A1GeneProduct6573 (Entrez Gene)
FructosamineMetaboliteHMDB02030 (HMDB)
PGF2aMetaboliteHMDB01139 (HMDB)
SAA2Protein6289 (Entrez Gene)
NFkB2GeneProduct4791 (Entrez Gene)
ADPMetaboliteHMDB01341 (HMDB)
FOLR2GeneProduct2350 (Entrez Gene)
IL6Protein3569 (Entrez Gene)
NFkB1GeneProduct4790 (Entrez Gene)
RiboflavinMetaboliteHMDB00244 (HMDB)
8-Isoprostaglandin F2aMetaboliteHMDB05083 (HMDB)
SAA4Protein6291 (Entrez Gene)
PGE1MetaboliteHMDB01442 (HMDB)
FMNMetaboliteHMDB01520 (HMDB)
FOLR3GeneProduct2352 (Entrez Gene)
ACTProtein12 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
FADMetaboliteHMDB01248 (HMDB)
F2-IsoprostaneMetabolite53788444 (PubChem)
S-nitrosohomocysteineMetabolite76468969 (PubChem)
SLC46A1GeneProduct113235 (Entrez Gene)
HOClMetaboliteHMDB01050 (HMDB)
FOLR4GeneProduct390243 (Entrez Gene)
INSProtein3630 (Entrez Gene)
FOLR1GeneProduct2348 (Entrez Gene)
HBA1Protein3039 (Entrez Gene)
PGE2Metabolite HMDB01220 (HMDB)
S-AdenosylhomocysteineMetabolite HMDB00939 (HMDB)
p53GeneProduct7157 (Entrez Gene)
MCP1GeneProduct6347 (Entrez Gene)
MTHFD2Protein10797 (Entrez Gene)
HDLMetabolite39025 (ChEBI)
MSR*Protein4552 (Entrez Gene)
VLDLMetabolite39027 (ChEBI)
AHCYProtein191 (Entrez Gene)
LDLMetabolite39026 (ChEBI)
SHMTProtein6472 (Entrez Gene)
LDLRProtein3949 (Entrez Gene)
DHFRProtein1719 (Entrez Gene)
TAGMetabolite17855 (ChEBI)
MATProtein4143 (Entrez Gene)
APOBProtein338 (Entrez Gene)
MTHFD1*Protein4522 (Entrez Gene)
Cob(I)alaminMetabolite HMDB02174 (HMDB)
MTR*Protein4548 (Entrez Gene)
MagnesiumMetaboliteHMDB00547 (HMDB)
CBSProtein875 (Entrez Gene)
ATPMetaboliteHMDB00538 (HMDB)
NADP+MetaboliteHMDB00217 (HMDB)
HNO2Metabolite25567 (ChEBI)
MPOProtein4353 (Entrez Gene)
CSF1Protein1435 (Entrez Gene)
CatalaseProtein847 (Entrez Gene)
CRPProtein1401 (Entrez Gene)
NOSProteinEC 1.14.13.39 (EC Number)
HbA1cProtein (Other)
CysteineMetaboliteHMDB00574 (HMDB)
sICAM-1Protein3383 (Entrez Gene)
Factor VIIProtein2155 (Entrez Gene)
FibrinProtein439199 (PubChem)
tPAProtein5327 (Entrez Gene)
MethionineMetaboliteHMDB00696 (HMDB)
PLGProtein5340 (Entrez Gene)
TetrahydrobiopterinMetaboliteHMDB00027 (HMDB)
PAI-1Protein5054 (Entrez Gene)
IronMetaboliteHMDB00692 (HMDB)
ThrombinProtein2147 (Entrez Gene)
GlycineMetaboliteHMDB00123 (HMDB)
GPX 4Protein2879 (Entrez Gene)
HDL/SAAMetabolite39025 (ChEBI)
H2O2MetaboliteHMDB03125 (HMDB)
SAA1Protein6288 (Entrez Gene)
10-Formyl-THFMetabolite HMDB00972 (HMDB)
APOA1Protein335 (Entrez Gene)
5,10-Methenyl-THFMetaboliteHMDB01354 (HMDB)
SAA3Protein6290 (Entrez Gene)
5-Formyl-THFMetaboliteHMDB01562 (HMDB)
HDL-CMetabolite47775 (ChEBI)
FGARMetabolite18272 (ChEBI)
APOA1-NO2TyrProtein335 (Entrez Gene)
(11R)-hydroxymethylene-THFMetabolite (Other)
SRB1Protein949 (Entrez Gene)
(11S)-hydroxymethylene-THFMetabolite (Other)
oxLDLMetabolite39026 (ChEBI)
DihydrofolateMetabolite HMDB01056 (HMDB)
CholesterolMetabolite HMDB00067 (HMDB)
GARMetaboliteHMDB02022 (HMDB)
VLDL-TAGMetabolite47776 (ChEBI)
5,10-Methylene-THFMetaboliteHMDB01533 (HMDB)
HDL/APOA1Metabolite39025 (ChEBI)
5-methyl-THFMetaboliteHMDB01396 (HMDB)
O2MetaboliteHMDB01377 (HMDB)
FolateMetabolite37445 (ChEBI)
8-OHdGMetabolite HMDB03333 (HMDB)
SOD3Protein6649 (Entrez Gene)
Cob(II)alaminMetabolite HMDB02174 (HMDB)
RFKProtein55312 (Entrez Gene)
ChlorineMetaboliteHMDB00492 (HMDB)
H2OMetaboliteHMDB02111 (HMDB)
CystathionineMetaboliteHMDB00099 (HMDB)
GPX 3Protein2878 (Entrez Gene)
SOD2Protein6648 (Entrez Gene)
CTHProtein1491 (Entrez Gene)
ZincMetaboliteHMDB01303 (HMDB)
HemeMetaboliteHMDB03178 (HMDB)
O3Metabolite25812 (ChEBI)
THFMetaboliteHMDB01846 (HMDB)
NOMetaboliteHMDB03378 (HMDB)
NADPHMetaboliteHMDB00221 (HMDB)
FibrinogenProteinGO:0005577 (Other)
GPX 6Protein257202 (Entrez Gene)
IL10Protein3458 (Entrez Gene)
ManganeseMetaboliteHMDB01333 (HMDB)
IL2Protein3558 (Entrez Gene)
Folic acidMetaboliteHMDB00121 (HMDB)
IFNgProtein3458 (Entrez Gene)
GPX 2Protein2877 (Entrez Gene)
IL1BProtein3553 (Entrez Gene)
GPX 1Protein2876 (Entrez Gene)
ALBProtein213 (Entrez Gene)
RNSMetabolite (Wikipedia)
HBBProtein3043 (Entrez Gene)
MTHFR*Protein4524 (Entrez Gene)
IL4Protein3565 (Entrez Gene)
GARTProtein2618 (Entrez Gene)
TNFaProtein7124 (Entrez Gene)
MTHFSProtein10588 (Entrez Gene)
D-dimerProtein (Wikipedia)
SHMTProtein6470 (Entrez Gene)
O2 · –Metabolite HMDB02168 (HMDB)
HomocysteineMetaboliteHMDB00742 (HMDB)
S-AdenosylmethionineMetaboliteHMDB01185 (HMDB)
SOD1Protein6647 (Entrez Gene)
NitrotyrosineMetaboliteHMDB01904 (HMDB)
Pyridoxal 5'-phosphateMetaboliteHMDB01491 (HMDB)
ONOO–/ONOOHMetabolite HMDB02179 (HMDB)
L-ArginineMetaboliteHMDB00517 (HMDB)
GlucoseMetabolite HMDB00122 (HMDB)
SerineMetaboliteHMDB00187 (HMDB)
FLAD1Protein80308 (Entrez Gene)
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