BMP signalling and regulation (Homo sapiens)

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Curation Tags

Description

"BMP signals are mediated by type I and II BMP receptors and their downstream molecules Smad1, 5 and 8. Phosphorylated Smad1, 5 and 8 proteins form a complex with Smad4 and then are translocated into the nucleus where they interact with other transcription factors, such as Runx2 in osteoblasts." (Chen 2004)

Ontology Tags

 

Bibliography

  1. Chen D, Zhao M, Mundy GR; ''Bone morphogenetic proteins.; ''Growth Factors, 2004 - PubMed

Categories


History

View all
CompareRevisionActionTimeUserComment
59105view22:20, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
44981view14:27, 6 October 2011MartijnVanIerselOntology Term : 'BMP signaling pathway ' added !
42559view18:50, 4 April 2011BabikerosmanPeriodical save, work in progress
42558view18:40, 4 April 2011BabikerosmanPeriodical save, work in progress
41051view23:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
39169view17:28, 26 October 2010VfunariPeriodical save, work in progress
38973view18:02, 25 September 2010AlexanderPicoModified description
38972view18:00, 25 September 2010AlexanderPicooverhaul
38955view00:33, 25 September 2010Khanspers
38954view00:32, 25 September 2010KhanspersAdded nucleus, changed line types
33373view14:35, 30 November 2009MaintBotRemoved group label
33180view17:42, 5 November 2009KhanspersModified categories
33113view12:21, 19 October 2009AndraNew pathway

External references

View all 12...

Name Type Database reference
TOB1GeneProductENSG00000141232 (Ensembl)
TOB2GeneProductENSG00000183864 (Ensembl)
BMPR2GeneProduct659 (Entrez Gene)
RUNX2GeneProductENSG00000124813 (Ensembl)
BMPR1AGeneProductENSG00000107779 (Ensembl)
BMP2GeneProductENSG00000125845 (Ensembl)
SMURF1GeneProductENSG00000198742 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SMAD6GeneProductENSG00000137834 (Ensembl)
BMPR1BPathwayENSG00000138696 (Ensembl)
SMAD1GeneProductENSG00000170365 (Ensembl)
NOGGeneProductENSG00000183691 (Ensembl)
Retrieved from "http://wikipathways.org/index.php/Pathway:WP1425"
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