wikipathways-collection

WikiPathways WP5143

• WikiPathways: WP5143 (classic)
• Species: Homo sapiens
• Scholia: WP5143

  Tests

• CASMetabolitesTests: all 2 tests OK!
• ChEBIMetabolitesTests: all 5 tests OK!
• ChemSpiderTests: all 2 tests OK!
• DataNodesTests: all 5 tests OK!
• EnsemblTests: all 4 tests OK!
• GeneTests: all 4 tests OK!
• GeneralTests: all 15 tests OK!
• HMDBSecMetabolitesTests: all 3 tests OK!
• InteractionTests
  • noMetaboliteToNonMetaboliteConversions: .. all OK!
  • noNonMetaboliteToMetaboliteConversions: .. all OK!
  • noGeneProteinConversions: .. all OK!
  • nonNumericIDs: .. all OK!
  • interactionsWithLabels: .x we found 1 problem(s):
    • Interactions found that involve Labels: 63
  • possibleTranslocations: .x we found 1 problem(s):
    • Interactions between identical nodes: 2
  • noProteinProteinConversions: .. all OK!
  • incorrectKEGGIdentifiers: .. all OK!
• KEGGMetaboliteTests: all 2 tests OK!
• LIPIDMAPSTests: all 1 tests OK!
• MetaboliteStructureTests: all 1 tests OK!
• MetabolitesTests: all 14 tests OK!
• OudatedDataSourcesTests: all 24 tests OK!
• PathwayTests: all 7 tests OK!
• ProteinsTests: all 2 tests OK!
• PubChemMetabolitesTests: all 3 tests OK!
• ReferencesTests: all 6 tests OK!
• UniProtTests: all 5 tests OK!
• WikidataTests: all 4 tests OK!

Summary

• Number of test classes: 20
• Number of tests: 117
• Number of assertions: 235
• Number of fails: 2

Fails

InteractionTests.interactionsWithLabels

Interactions found that involve Labels: 63

http://classic.wikipathways.org/instance/WP5143_r124544 "Dopamine
biosynthesis" with graphId becd4
http://classic.wikipathways.org/instance/WP5143_r124544 "Branching
morphogenesis" with graphId c846c
http://classic.wikipathways.org/instance/WP5143_r124544 "Neurite
outgrowth" with graphId d2c7d
http://classic.wikipathways.org/instance/WP5143_r124544 "In
MN9D
cells" with graphId d0949
http://classic.wikipathways.org/instance/WP5143_r124544 "Protection of
dopaminergic 
neurons from
6-OHDA toxicity" with graphId dcd1c
http://classic.wikipathways.org/instance/WP5143_r124544 "Dental pulp
stem cell
migration" with graphId d2699
http://classic.wikipathways.org/instance/WP5143_r124544 "In MN1
cells" with graphId a7db9
http://classic.wikipathways.org/instance/WP5143_r124544 "Degradation" with graphId fd2ac
http://classic.wikipathways.org/instance/WP5143_r124544 "Survival of
granule and
sympathetic
neurons" with graphId a08a6
http://classic.wikipathways.org/instance/WP5143_r124544 "Degradation of RET 
or dissociation of 
CD2AP/CBLC complex 
from RET receptor " with graphId ecc7d
http://classic.wikipathways.org/instance/WP5143_r124544 "Self-renewal
in female 
germline
stem Cells" with graphId b2228
http://classic.wikipathways.org/instance/WP5143_r124544 "Survival of
the enteric
nervous
system" with graphId cbca9
http://classic.wikipathways.org/instance/WP5143_r124544 "PKCs" with graphId e28e8
http://classic.wikipathways.org/instance/WP5143_r124544 "Schwann cell
migration and
axonal growth
in hippocampal
and cortical
neurons" with graphId f56f6
http://classic.wikipathways.org/instance/WP5143_r124544 " Motor
 axon
 guidance" with graphId b666d
http://classic.wikipathways.org/instance/WP5143_r124544 "Statbilization
of active RET" with graphId ed0ed
http://classic.wikipathways.org/instance/WP5143_r124544 "In motor neuron
CAD, and Superior
Cervical Ganglia
Cells" with graphId aa471
http://classic.wikipathways.org/instance/WP5143_r124544 "GDNF-RET
interaction" with graphId f438b
http://classic.wikipathways.org/instance/WP5143_r124544 "In substantia
nigra neurons" with graphId ce9ee
http://classic.wikipathways.org/instance/WP5143_r124544 "Proliferation
of immature
sertoli cells" with graphId f2b4b
http://classic.wikipathways.org/instance/WP5143_r124544 "SRC
family
kinases" with graphId b8523
http://classic.wikipathways.org/instance/WP5143_r124544 "14-3-3s" with graphId d1266
http://classic.wikipathways.org/instance/WP5143_r124544 "Anti-
apoptosis" with graphId fe601
http://classic.wikipathways.org/instance/WP5143_r124544 "Neurite
outgrowth &
survival of
sympathetic
Neurons" with graphId f5a69
http://classic.wikipathways.org/instance/WP5143_r124544 "Ezrin-
associated
fliopedia
formation" with graphId b2fa6
http://classic.wikipathways.org/instance/WP5143_r124544 "Spermatogonial
stem cell renewal" with graphId e0711
http://classic.wikipathways.org/instance/WP5143_r124544 "Positive feedback
loop of ST3GAL1 &
GDNF/GFRA1 pathway
in breast cancers" with graphId a43ed
http://classic.wikipathways.org/instance/WP5143_r124544 "Migration of
chondrosarcoma
cells" with graphId abf7b
http://classic.wikipathways.org/instance/WP5143_r124544 "DSG2-mediated
adhesion in
enterocytes" with graphId e78fc
http://classic.wikipathways.org/instance/WP5143_r124544 "Regulation of
GDNF-GFRA1-RET
complex assembly" with graphId bf739
http://classic.wikipathways.org/instance/WP5143_r124544 "GDNF-dependent
Drug resistance
in ER+ breast
cancer cells" with graphId c633f
http://classic.wikipathways.org/instance/WP5143_r124544 "Proliferation of
permatogonial
progenitor cells" with graphId eb2e3
http://classic.wikipathways.org/instance/WP5143_r124544 "Lysosomal
processing
of GDNF" with graphId c38b8
http://classic.wikipathways.org/instance/WP5143_r124544 "Enhancement of axonal 
sprouting, synaptic 
connectivity & GABAergic
neurotransmission
in the spinal cord" with graphId b1b54
http://classic.wikipathways.org/instance/WP5143_r124544 "Spermatogonial
stem cell
proliferation" with graphId c330d
http://classic.wikipathways.org/instance/WP5143_r124544 "In MN1
& RM33B
cells" with graphId eeb4f
http://classic.wikipathways.org/instance/WP5143_r124544 "Cell migration
and chemotaxis
of HCC1833 and
A549 cells" with graphId e595c
http://classic.wikipathways.org/instance/WP5143_r124544 "Activation
of hedgehog
pathway and
proliferation
& tumor growth" with graphId a1585
http://classic.wikipathways.org/instance/WP5143_r124544 "Clathrin-mediated
internalization
of RET-51
isoform complex" with graphId f7fa6
http://classic.wikipathways.org/instance/WP5143_r124544 "Hepatic
stellate
cell
activation" with graphId cb4c9
http://classic.wikipathways.org/instance/WP5143_r124544 "pHEndEC
F-actin 
cytoskeletal 
filament 
relocation to
intercellular 
membranes" with graphId f7d4f
http://classic.wikipathways.org/instance/WP5143_r124544 "Neuronal
differentiation
of PC12 cells" with graphId a2e1b
http://classic.wikipathways.org/instance/WP5143_r124544 "Metastasis &
migration of
HCT116 & SW480 
colon cancer
cells and U251
glioblastoma
cell line " with graphId d2da0
http://classic.wikipathways.org/instance/WP5143_r124544 "Regulation
of Dopamine
transporter
trafficking" with graphId d07dd
http://classic.wikipathways.org/instance/WP5143_r124544 "Suppression of
triglycerides
accumulation in
3T3-L1 adipocytes
and HepG2 cells" with graphId f6514
http://classic.wikipathways.org/instance/WP5143_r124544 "In brown
adipocytes" with graphId c598f
http://classic.wikipathways.org/instance/WP5143_r124544 "Neuronal
survival" with graphId e0b26
http://classic.wikipathways.org/instance/WP5143_r124544 "Migration
of SOX1+ 
Enteric 
Ganglion
precursors" with graphId d4fa0
http://classic.wikipathways.org/instance/WP5143_r124544 "Translocation
to lipid rafts" with graphId f545f
http://classic.wikipathways.org/instance/WP5143_r124544 "Neuro-
protection" with graphId d593c
http://classic.wikipathways.org/instance/WP5143_r124544 "Excitation of
Dopaminergic
neurons in 
midbrain" with graphId aca26
http://classic.wikipathways.org/instance/WP5143_r124544 "ERK/AKT
independent
signaling
pathway" with graphId a13af
http://classic.wikipathways.org/instance/WP5143_r124544 "Protection of
dopaminergic
neurons" with graphId bbcae
http://classic.wikipathways.org/instance/WP5143_r124544 "Regulation of
GDNF-induced 
neurotropic
activity by
endocytosis
of RET" with graphId cc5a4
http://classic.wikipathways.org/instance/WP5143_r124544 "Suppression of
Differentiation
of Spermatogonial
Stem Cells" with graphId eaece
http://classic.wikipathways.org/instance/WP5143_r124544 "Maintainance of
latency/suppression
of HSV-1
reactivation" with graphId e6b05
http://classic.wikipathways.org/instance/WP5143_r124544 "VEGFA
signaling" with graphId e5a0a
http://classic.wikipathways.org/instance/WP5143_r124544 "Migration and
Invasion of
Pancreatic
Carcinoma
Cells" with graphId e4d29
http://classic.wikipathways.org/instance/WP5143_r124544 "GFRA1
sorting
to Trans-
Golgi
network" with graphId fe475
http://classic.wikipathways.org/instance/WP5143_r124544 "Enteric
neuronal
survival" with graphId bc183
http://classic.wikipathways.org/instance/WP5143_r124544 "Migration
of corneal
epithelial
cells" with graphId c82ec
http://classic.wikipathways.org/instance/WP5143_r124544 "Migration of
neurons to
cortical plate" with graphId c9f5b
http://classic.wikipathways.org/instance/WP5143_r124544 "Calbindin-
positive 
striatal
neuron
differentiation" with graphId bd6d2

Possible MIM translocation

Interactions between identical nodes: 2

http://classic.wikipathways.org/instance/WP5143_r124544 http://rdf.wikipathways.org/Pathway/WP5143_r124544/WP/Interaction/aa19d "Ca2+" (https://identifiers.org/pubchem.compound/271) and 
Ca2+" (https://identifiers.org/pubchem.compound/271)
http://classic.wikipathways.org/instance/WP5143_r124544 http://rdf.wikipathways.org/Pathway/WP5143_r124544/WP/Interaction/a8652 "Sphingosine- 1-Phosphate" (https://identifiers.org/pubchem.compound/5283560) and 
Sphingosine- 1-Phosphate" (https://identifiers.org/pubchem.compound/5283560)

More details at https://www.wikipathways.org/WikiPathwaysCurator/InteractionTests/possibleTranslocations