ENSG00000025039 Ensembl Human ENSG00000116954 Ensembl Human ENSG00000186654 Ensembl Human ENSG00000135362 Ensembl Human ENSG00000083750 Ensembl Human ENSG00000155876 Ensembl Human ULK3 ENSG00000111725 Ensembl Human ENSG00000162409 Ensembl Human Homo sapiens AKT1S1 TOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central regulator that consists in two different complexes: a rapamycin-sensitive complex (mTORC1) consisting of mTOR, Raptor and GbetaL that regulates mRNA translation, ribosome biogenesis and autophagy and a second rapamycin-insensitive complex (mTORC2) consisting of mTOR, Rictor GbetaL, Sin1 and Protor 1/2 that regulates survival and a cytoskeletal response. TOR signaling is highly integrated in other signaling pathways that respond to external conditions, such as the insulin-signaling cascade and AMPK signaling. (WikiPathways-description) Cellular Process (WikiPathways-category) TOR signaling ENSG00000132356 Ensembl Human ENSG00000131791 Ensembl Human ENSG00000187840 Ensembl Human 7847818 PubChem MTOR ENSG00000198793 Ensembl Human ENSG00000154229 Ensembl Human PRKAA1 PRKAG2 MLST8 AKT1 ENSG00000119487 Ensembl Human ENSG00000204673 Ensembl Human ENSG00000108443 Ensembl Human FKBP1A PRR5L DDIT4L ENSG00000088832 Ensembl Human PRKCA ULK1 RRAGD CDC42 ULK2 ENSG00000141564 Ensembl Human RAC1 ENSG00000106615 Ensembl Human ENSG00000083290 Ensembl Human ENSG00000140474 Ensembl Human ENSG00000142208 Ensembl Human ENSG00000177169 Ensembl Human TSC1 ENSG00000103197 Ensembl Human PRKAB2 DDIT4 ENSG00000164327 Ensembl Human ENSG00000167965 Ensembl Human ENSG00000165699 Ensembl Human PRKAG3 PRKAA2 RPS6KB1 MLST8 Rapamycin ENSG00000181929 Ensembl Human MAPKAP1 PRKAG1 ENSG00000106617 Ensembl Human ENSG00000070831 Ensembl Human RICTOR 2009 Rag proteins regulate amino-acid-induced mTORC1 signalling. 19143648 Biochem Soc Trans PubMed Sabatini DM Sancak Y ENSG00000115592 Ensembl Human ENSG00000136238 Ensembl Human RRAGA RRAGC RPTOR MTOR EIF4EBP1 ENSG00000145358 Ensembl Human RHEB PRKAB1 ENSG00000168209 Ensembl Human TSC2 PRR5 RRAGB