TCA Cycle (Homo sapiens)

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Description

The citric acid cycle, also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle, (or rarely, the Szent-Gyorgyi-Krebs cycle) is a series of enzyme-catalysed chemical reactions of central importance in all living cells that use oxygen as part of cellular respiration. In eukaryotes, the citric acid cycle occurs in the matrix of the mitochondrion. The components and reactions of the citric acid cycle were established by seminal work from both Albert Szent-Gyorgyi and Hans Krebs. Source: Wikipedia (wikipedia:citric_acid_cycle)

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Bibliography

View all 15 references
  1. Lawson AM, Chalmers RA, Watts RW; ''Urinary organic acids in man. I. Normal patterns.; ''Clin Chem, 1976 - PubMed
  2. Des Rosiers C, Di Donato L, Comte B, Laplante A, Marcoux C, David F, Fernandez CA, Brunengraber H; ''Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis.; ''J Biol Chem, 1995 - PubMed
  3. Sazanov LA, Jackson JB; ''Proton-translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria.; ''FEBS Lett, 1994 - PubMed
  4. Gabriel JL, Zervos PR, Plaut GW; ''Activity of purified NAD-specific isocitrate dehydrogenase at modulator and substrate concentrations approximating conditions in mitochondria.; ''Metabolism, 1986 - PubMed
  5. Krebs HA, Holzach O; ''The conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase.; ''Biochem J, 1952 - PubMed
  6. Krebs, H. A., Johnson, W. A.; ''The Role of Citric Acid in Intermediate Metabolism in Animal Tissues.; ''Enzymologia, 1937
  7. Sheu KF, Blass JP; ''The alpha-ketoglutarate dehydrogenase complex.; ''Ann N Y Acad Sci, 1999 - PubMed
  8. Fernandez CA, Des Rosiers C; ''Modeling of liver citric acid cycle and gluconeogenesis based on 13C mass isotopomer distribution analysis of intermediates.; ''J Biol Chem, 1995 - PubMed
  9. Johnson JD, Muhonen WW, Lambeth DO; ''Characterization of the ATP- and GTP-specific succinyl-CoA synthetases in pigeon. The enzymes incorporate the same alpha-subunit.; ''J Biol Chem, 1998 - PubMed
  10. Hoek JB, Rydström J; ''Physiological roles of nicotinamide nucleotide transhydrogenase.; ''Biochem J, 1988 - PubMed
  11. Lambeth DO, Tews KN, Adkins S, Frohlich D, Milavetz BI; ''Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues.; ''J Biol Chem, 2004 - PubMed
  12. Greksák M, Lopes-Cardozo M, van den Bergh SG; ''Citrate synthesis in intact rat-liver mitochondria is irreversible.; ''Eur J Biochem, 1982 - PubMed
  13. Liu TC, Kim H, Arizmendi C, Kitano A, Patel MS; ''Identification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient.; ''Proc Natl Acad Sci U S A, 1993 - PubMed
  14. Des Rosiers C, Fernandez CA, David F, Brunengraber H; ''Reversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver. Evidence from isotopomer analysis of citric acid cycle intermediates.; ''J Biol Chem, 1994 - PubMed
  15. Comte B, Vincent G, Bouchard B, Benderdour M, Des Rosiers C; ''Reverse flux through cardiac NADP(+)-isocitrate dehydrogenase under normoxia and ischemia.; ''Am J Physiol Heart Circ Physiol, 2002 - PubMed

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History

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CompareRevisionActionTimeUserComment
59783view22:02, 7 March 2013Khanspersminor change
59770view17:53, 7 March 2013Khanspersminor layout change
59769view17:51, 7 March 2013Khanspersadded bounding rectangle to pathway nodes
59710view19:48, 6 March 2013AlexanderPicoSimplified SUCLG reaction; additional minor layout and label fixes
59709view19:22, 6 March 2013AlexanderPicoPeriodical save, work in progress
59708view19:17, 6 March 2013AlexanderPicoRemoved incomplete H+ accounting
59707view19:13, 6 March 2013AlexanderPicoFixing layout, labels, node size, arrows
47741view15:54, 5 April 2012MdstobbeMinor layout change.
47740view15:50, 5 April 2012MdstobbeChanged to Entrez Gene IDs.
47731view16:50, 4 April 2012MdstobbeAdded 3 more literature references.
47724view11:56, 4 April 2012MdstobbePeriodical save, work in progress
47723view11:46, 4 April 2012MdstobbePeriodical save, work in progress
47722view11:36, 4 April 2012MdstobbePeriodical save, work in progress
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47681view21:31, 2 April 2012Mdstobbesmall change to lit. ref.
47680view21:26, 2 April 2012MdstobbeAdded reference and switched the two IDH reactions from place.
47679view21:06, 2 April 2012MdstobbePeriodical save, work in progress
47654view16:37, 2 April 2012SmhoutenRefinements
47580view14:58, 29 March 2012MdstobbeAdded literature references
47579view14:54, 29 March 2012MdstobbePeriodical save, work in progress
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47469view20:59, 20 March 2012MdstobbePeriodical save, work in progress
47452view22:45, 19 March 2012MdstobbeCorrected directions
47451view22:28, 19 March 2012MdstobbeAdded IDs
47407view17:08, 18 March 2012MdstobbePeriodical save, work in progress
47406view16:33, 18 March 2012MdstobbeAdded cosubstrates and removed reactions that are not part of the TCA cycle. Furthermore, enzymes were corrected where necessary.
47405view16:29, 18 March 2012MdstobbePeriodical save, work in progress
47404view16:19, 18 March 2012MdstobbePeriodical save, work in progress
47403view16:00, 18 March 2012MdstobbePeriodical save, work in progress
47402view15:30, 18 March 2012MdstobbePeriodical save, work in progress
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47400view15:05, 18 March 2012MdstobbePeriodical save, work in progress
47399view14:45, 18 March 2012MdstobbePeriodical save, work in progress
47398view14:35, 18 March 2012MdstobbePeriodical save, work in progress
47397view13:26, 18 March 2012MdstobbeAdded intermediate step for citrate->isocitrate

External references

View all 49...

Name Type Database reference
Degradation of odd chain Fatty Acids and specific Amino AcidsPathwayWP143 (WikiPathways)
H+Metabolite
carbon dioxideMetaboliteHMDB01967 (HMDB)
Carbon dioxideMetaboliteHMDB01967 (HMDB)
CoAMetaboliteHMDB01423 (HMDB)
H+Metabolite15378 (ChEBI)
ACO2GeneProduct50 (Entrez Gene)
NADHMetaboliteHMDB01487 (HMDB)
NADMetaboliteHMDB00902 (HMDB)
FHGeneProduct2271 (Entrez Gene)
ADPMetaboliteHMDB01341 (HMDB)
SDHCGeneProduct6391 (Entrez Gene)
SDHDGeneProduct6392 (Entrez Gene)
D-threo-IsocitrateMetaboliteHMDB00193 (HMDB)
SDHBGeneProduct6390 (Entrez Gene)
Succinyl-CoAMetaboliteHMDB01022 (HMDB)
Degradation of Fatty Acids, Glucose and specific Amino AcidsPathwayWP143 (WikiPathways)
2-oxoglutarateMetaboliteHMDB00208 (HMDB)
NADP+MetaboliteHMDB00217 (HMDB)
SUCLG2GeneProduct8801 (Entrez Gene)
phosphateMetaboliteHMDB01429 (HMDB)
CSGeneProduct1431 (Entrez Gene)
Ubiquinone-10MetaboliteHMDB01072 (HMDB)
DLDGeneProduct1738 (Entrez Gene)
WaterMetaboliteHMDB02111 (HMDB)
DLSTGeneProduct1743 (Entrez Gene)
CitrateMetaboliteHMDB00094 (HMDB)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
SuccinateMetaboliteHMDB00254 (HMDB)
IDH3BGeneProduct3420 (Entrez Gene)
Electron Transport ChainPathwayWP111 (WikiPathways)
IDH3AGeneProduct3419 (Entrez Gene)
Fatty Acid SynthesisPathwayWP357 (WikiPathways)
SUCLG1GeneProduct8802 (Entrez Gene)
cis-aconitateMetaboliteHMDB00072 (HMDB)
SDHAGeneProduct6389 (Entrez Gene)
IDH2GeneProduct3418 (Entrez Gene)
MDH2GeneProduct4191 (Entrez Gene)
NADPHMetaboliteHMDB00221 (HMDB)
IDH3GGeneProduct3421 (Entrez Gene)
GDPMetaboliteHMDB01201 (HMDB)
OGDHGeneProduct4967 (Entrez Gene)
GTPMetaboliteHMDB01273 (HMDB)
(S)-malateMetaboliteHMDB00156 (HMDB)
ATPMetaboliteHMDB00538 (HMDB)
OxaloacetateMetaboliteHMDB00223 (HMDB)
ubiquinol-10MetaboliteHMDB13111 (HMDB)
FumarateMetaboliteHMDB00134 (HMDB)
SUCLA2GeneProduct8803 (Entrez Gene)
Retrieved from "http://wikipathways.org/index.php/Pathway:WP78"
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