Estrogen signaling pathway (Homo sapiens)

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Curation Tags

Description

Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.

Ontology Tags

 

Bibliography

  1. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.; ''J Leukoc Biol, 2008 - PubMed
  2. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.; ''Proc Natl Acad Sci U S A, 2006 - PubMed
  3. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.; ''J Biol Chem, 2006 - PubMed

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History

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CompareRevisionActionTimeUserComment
63186view20:45, 8 May 2013MaintBotUpdating gpml version
59090view22:08, 21 February 2013MaintBotUpdated Ensembl data source
48214view05:28, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45247view18:33, 7 October 2011AlexanderPicoOntology Term : 'estrogen signaling pathway' added !
41039view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
39752view06:49, 17 January 2011AlexanderPico
38812view08:50, 24 September 2010Jildaunucleus
34842view09:12, 27 January 2010Vtriver6Specify description
34841view09:10, 27 January 2010Vtriver6Specify description
34840view09:09, 27 January 2010Vtriver6Specify description
34839view09:06, 27 January 2010Vtriver6ER signaling
34838view07:51, 27 January 2010Vtriver6Periodical save, work in progress
33422view14:53, 30 November 2009MaintBotRemoved group label
29739view22:35, 1 June 2009KhanspersModified categories
29675view11:39, 26 May 2009LauravanzonSpecify description
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29587view08:32, 19 May 2009LauravanzonModified description
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29561view07:55, 18 May 2009LauravanzonNew pathway

External references

View all 80...

Name Type Database reference
Estradiol (E2)Metabolite5757 (PubChem)
SIN3GeneProduct25942 (Entrez Gene)
ERGeneProduct2099 (Entrez Gene)
BRCA1GeneProduct672 (Entrez Gene)
p300GeneProduct2033 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
CBPGeneProduct1387 (Entrez Gene)
NFKBGeneProduct4790 (Entrez Gene)
TFIIAGeneProduct2958 (Entrez Gene)
HDAC1GeneProduct3065 (Entrez Gene)
TBPGeneProduct6908 (Entrez Gene)
RAFGeneProduct673 (Entrez Gene)
ILKGeneProduct3611 (Entrez Gene)
JNKsGeneProduct5601 (Entrez Gene)
GTF2H2GeneProduct2966 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
GTF2E2GeneProduct2961 (Entrez Gene)
GSAGeneProduct2778 (Entrez Gene)
ERCC2GeneProduct2068 (Entrez Gene)
HDAC3GeneProduct8841 (Entrez Gene)
GTF2A2GeneProduct2958 (Entrez Gene)
HDAC2GeneProduct3066 (Entrez Gene)
MNAT1GeneProduct4331 (Entrez Gene)
SHCGeneProduct25759 (Entrez Gene)
TAF12GeneProduct6883 (Entrez Gene)
ELKGeneProduct2002 (Entrez Gene)
TAF9GeneProduct6880 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
GTF2BGeneProduct2959 (Entrez Gene)
PKB/AktGeneProduct207 (Entrez Gene)
TAF5GeneProduct6877 (Entrez Gene)
PKACAGeneProduct5566 (Entrez Gene)
TAF6GeneProduct6878 (Entrez Gene)
IKK-gammaGeneProductENSG00000073009 (Ensembl Human)
TAF7GeneProduct6879 (Entrez Gene)
c-JunGeneProduct3725 (Entrez Gene)
GTF2H3GeneProduct2967 (Entrez Gene)
GNGT1GeneProduct2792 (Entrez Gene)
GTF2F2GeneProduct2963 (Entrez Gene)
ER-ATF2GeneProduct2099 (Entrez Gene)
TAF13GeneProduct6884 (Entrez Gene)
HDAC6GeneProduct10013 (Entrez Gene)
ERCC3GeneProduct2071 (Entrez Gene)
HDAC7AGeneProduct51564 (Entrez Gene)
CDK7GeneProduct1022 (Entrez Gene)
HDAC8GeneProduct55869 (Entrez Gene)
GTF2E1GeneProduct2960 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCNHGeneProduct902 (Entrez Gene)
ERKGeneProductENSG00000100030 (Ensembl Human)
GTF2H4GeneProduct2968 (Entrez Gene)
RASGeneProductENSG00000174775 (Ensembl Human)
GTF2H1GeneProduct2965 (Entrez Gene)
MEKGeneProductENSG00000169032 (Ensembl Human)
POLR2EGeneProduct5434 (Entrez Gene)
SOSGeneProduct6654 (Entrez Gene)
POLR2HGeneProduct5437 (Entrez Gene)
p38GeneProduct1432 (Entrez Gene)
POLR2BGeneProduct5431 (Entrez Gene)
PI3KGeneProduct5290 (Entrez Gene)
POLR2FGeneProduct5435 (Entrez Gene)
Cyclic AMPMetabolite6076 (PubChem)
POLR2CGeneProduct5432 (Entrez Gene)
EstradiolMetabolite5757 (PubChem)
POLR2JGeneProduct5439 (Entrez Gene)
CREBGeneProduct1385 (Entrez Gene)
POLR2KGeneProduct5440 (Entrez Gene)
IKK-betaGeneProductENSG00000104365 (Ensembl Human)
POLR2GGeneProduct5436 (Entrez Gene)
IKK-alphaGeneProductENSG00000213341 (Ensembl Human)
POLR2IGeneProduct5438 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
POLR2AGeneProduct5430 (Entrez Gene)
C-FOSGeneProduct2353 (Entrez Gene)
N-CoRGeneProduct9611 (Entrez Gene)
GNB1GeneProduct2782 (Entrez Gene)
HDAC4GeneProduct9759 (Entrez Gene)
GPR30GeneProduct2852 (Entrez Gene)
HDAC5GeneProduct10014 (Entrez Gene)
ER-ATF1GeneProduct2099 (Entrez Gene)
Retrieved from "http://wikipathways.org/index.php/Pathway:WP712"
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