ErbB signaling pathway (Homo sapiens)
The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. In mice loss of signaling by any member of the ErbB family results in embryonic lethality with defects in organs including the lungs, skin, heart and brain. Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are found in many human cancers and their excessive signaling may be critical factors in the development and malignancy of these tumors.
The ErbB protein family consists of 4 members
* ErbB-1, also named epidermal growth factor receptor (EGFR) * ErbB-2, also named HER2 in humans and neu in rodents * ErbB-3, also named HER3 and * ErbB-4, also named HER4
The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher order oligomers upon activation by a subset of potential growth factor ligands.
View all 16 references
- Muthuswamy SK, Gilman M, Brugge JS; ''Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers.; ''Mol Cell Biol, 1999 - PubMed
- Olayioye MA, Neve RM, Lane HA, Hynes NE; ''The ErbB signaling network: receptor heterodimerization in development and cancer.; ''EMBO J, 2000 - PubMed
- Hynes NE, Lane HA; ''ERBB receptors and cancer: the complexity of targeted inhibitors.; ''Nat Rev Cancer, 2005 - PubMed
- McCarty JH; ''The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events.; ''Bioessays, 1998 - PubMed
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|RAS||GeneProduct||ENSG00000174775 (Ensembl Human)|
|TGFA||GeneProduct||7039 (Entrez Gene)|
|EGF||GeneProduct||1950 (Entrez Gene)|
|AREG||GeneProduct||374 (Entrez Gene)|
|PKB/Akt||GeneProduct||207 (Entrez Gene)|