ErbB signaling pathway (Homo sapiens)

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Description

The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. In mice loss of signaling by any member of the ErbB family results in embryonic lethality with defects in organs including the lungs, skin, heart and brain. Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are found in many human cancers and their excessive signaling may be critical factors in the development and malignancy of these tumors.

The ErbB protein family consists of 4 members 

   * ErbB-1, also named epidermal growth factor receptor (EGFR)
   * ErbB-2, also named HER2 in humans and neu in rodents
   * ErbB-3, also named HER3 and
   * ErbB-4, also named HER4

The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher order oligomers upon activation by a subset of potential growth factor ligands.


Ontology Tags

 

Bibliography

View all 16 references
  1. Muthuswamy SK, Gilman M, Brugge JS; ''Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers.; ''Mol Cell Biol, 1999 - PubMed
  2. Olayioye MA, Neve RM, Lane HA, Hynes NE; ''The ErbB signaling network: receptor heterodimerization in development and cancer.; ''EMBO J, 2000 - PubMed
  3. Hynes NE, Lane HA; ''ERBB receptors and cancer: the complexity of targeted inhibitors.; ''Nat Rev Cancer, 2005 - PubMed
  4. McCarty JH; ''The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events.; ''Bioessays, 1998 - PubMed
  5. Schulze WX, Deng L, Mann M; ''Phosphotyrosine interactome of the ErbB-receptor kinase family.; ''Mol Syst Biol, 2005 - PubMed
  6. Citri A, Yarden Y; ''EGF-ERBB signalling: towards the systems level.; ''Nat Rev Mol Cell Biol, 2006 - PubMed
  7. Clark DE, Williams CC, Duplessis TT, Moring KL, Notwick AR, Long W, Lane WS, Beuvink I, Hynes NE, Jones FE; ''ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events.; ''J Biol Chem, 2005 - PubMed
  8. Liang J, Slingerland JM; ''Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression.; ''Cell Cycle, 2003 - PubMed
  9. Normanno N, De Luca A, Bianco C, Strizzi L, Mancino M, Maiello MR, Carotenuto A, De Feo G, Caponigro F, Salomon DS; ''Epidermal growth factor receptor (EGFR) signaling in cancer.; ''Gene, 2006 - PubMed
  10. Yarden Y, Sliwkowski MX; ''Untangling the ErbB signalling network.; ''Nat Rev Mol Cell Biol, 2001 - PubMed
  11. Oda K, Matsuoka Y, Funahashi A, Kitano H; ''A comprehensive pathway map of epidermal growth factor receptor signaling.; ''Mol Syst Biol, 2005 - PubMed
  12. Ryan DP, Engelman JA, Ferrone CR, Sahani DV, Lisovsky M; ''Case records of the Massachusetts General Hospital. Case 19-2010. A 35-year-old man with adenocarcinoma of the cecum.; ''N Engl J Med, 2010 - PubMed
  13. Hashimoto Y, Katayama H, Kiyokawa E, Ota S, Kurata T, Gotoh N, Otsuka N, Shibata M, Matsuda M; ''Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor.; ''J Biol Chem, 1998 - PubMed
  14. Marmor MD, Skaria KB, Yarden Y; ''Signal transduction and oncogenesis by ErbB/HER receptors.; ''Int J Radiat Oncol Biol Phys, 2004 - PubMed
  15. Scaltriti M, Baselga J; ''The epidermal growth factor receptor pathway: a model for targeted therapy.; ''Clin Cancer Res, 2006 - PubMed
  16. Holbro T, Hynes NE; ''ErbB receptors: directing key signaling networks throughout life.; ''Annu Rev Pharmacol Toxicol, 2004 - PubMed

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63184view20:44, 8 May 2013MaintBotUpdating gpml version
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38179view04:20, 22 August 2010AlexanderPicoConverted pathway objects
38178view04:16, 22 August 2010AlexanderPicoAdded literature references
38177view04:10, 22 August 2010AlexanderPicoConverted pathway objects
38176view04:01, 22 August 2010AlexanderPicoSpecify description
38175view03:59, 22 August 2010AlexanderPicoAdded reference and more EGFR connections
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29836view10:01, 4 June 2009UomoamareAll nodes annotated through NCBI-GeneID
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External references

View all 47...

Name Type Database reference
RASGeneProductENSG00000174775 (Ensembl Human)
TGFAGeneProduct7039 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
AREGGeneProduct374 (Entrez Gene)
PKB/AktGeneProduct207 (Entrez Gene)
BTCGeneProduct685 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
HBEGFGeneProduct1839 (Entrez Gene)
MycGeneProduct4609 (Entrez Gene)
EREGGeneProduct2069 (Entrez Gene)
p27GeneProduct1027 (Entrez Gene)
NRG1GeneProduct3084 (Entrez Gene)
Jnkk2GeneProduct5609 (Entrez Gene)
NRG2GeneProduct9542 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
NRG3GeneProduct10718 (Entrez Gene)
MEKGeneProductENSG00000169032 (Ensembl Human)
NRG4GeneProduct145957 (Entrez Gene)
GAB1GeneProduct2549 (Entrez Gene)
ERBB1GeneProduct1956 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
ERBB2GeneProduct2064 (Entrez Gene)
p70S6KGeneProduct6199 (Entrez Gene)
ERBB3GeneProduct2065 (Entrez Gene)
PAK4GeneProduct10298 (Entrez Gene)
ERBB4GeneProduct2066 (Entrez Gene)
JNKGeneProduct5599 (Entrez Gene)
PLCGGeneProduct5335 (Entrez Gene)
SHCGeneProduct25759 (Entrez Gene)
CAMK2AGeneProduct815 (Entrez Gene)
SOSGeneProduct6654 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
RAFGeneProduct673 (Entrez Gene)
CBLGeneProduct23624 (Entrez Gene)
ERKGeneProductENSG00000100030 (Ensembl Human)
STAT5GeneProduct6776 (Entrez Gene)
ELKGeneProduct2002 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
PI3KGeneProduct5290 (Entrez Gene)
FAKGeneProduct5747 (Entrez Gene)
mTORGeneProduct2475 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
GSK3GeneProduct2932 (Entrez Gene)
ABLGeneProduct25 (Entrez Gene)
p21GeneProduct1026 (Entrez Gene)
NCKGeneProduct4690 (Entrez Gene)
eIF-4EBPGeneProduct1978 (Entrez Gene)
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