ErbB signaling pathway (Homo sapiens)

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Bibliography

View all 16 references
  1. Muthuswamy SK, Gilman M, Brugge JS; ''Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers.; ''Mol Cell Biol, 1999 - PubMed
  2. Olayioye MA, Neve RM, Lane HA, Hynes NE; ''The ErbB signaling network: receptor heterodimerization in development and cancer.; ''EMBO J, 2000 - PubMed
  3. Hynes NE, Lane HA; ''ERBB receptors and cancer: the complexity of targeted inhibitors.; ''Nat Rev Cancer, 2005 - PubMed
  4. McCarty JH; ''The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events.; ''Bioessays, 1998 - PubMed
  5. Schulze WX, Deng L, Mann M; ''Phosphotyrosine interactome of the ErbB-receptor kinase family.; ''Mol Syst Biol, 2005 - PubMed
  6. Citri A, Yarden Y; ''EGF-ERBB signalling: towards the systems level.; ''Nat Rev Mol Cell Biol, 2006 - PubMed
  7. Clark DE, Williams CC, Duplessis TT, Moring KL, Notwick AR, Long W, Lane WS, Beuvink I, Hynes NE, Jones FE; ''ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events.; ''J Biol Chem, 2005 - PubMed
  8. Liang J, Slingerland JM; ''Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression.; ''Cell Cycle, 2003 - PubMed
  9. Normanno N, De Luca A, Bianco C, Strizzi L, Mancino M, Maiello MR, Carotenuto A, De Feo G, Caponigro F, Salomon DS; ''Epidermal growth factor receptor (EGFR) signaling in cancer.; ''Gene, 2006 - PubMed
  10. Yarden Y, Sliwkowski MX; ''Untangling the ErbB signalling network.; ''Nat Rev Mol Cell Biol, 2001 - PubMed
  11. Oda K, Matsuoka Y, Funahashi A, Kitano H; ''A comprehensive pathway map of epidermal growth factor receptor signaling.; ''Mol Syst Biol, 2005 - PubMed
  12. Ryan DP, Engelman JA, Ferrone CR, Sahani DV, Lisovsky M; ''Case records of the Massachusetts General Hospital. Case 19-2010. A 35-year-old man with adenocarcinoma of the cecum.; ''N Engl J Med, 2010 - PubMed
  13. Hashimoto Y, Katayama H, Kiyokawa E, Ota S, Kurata T, Gotoh N, Otsuka N, Shibata M, Matsuda M; ''Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor.; ''J Biol Chem, 1998 - PubMed
  14. Marmor MD, Skaria KB, Yarden Y; ''Signal transduction and oncogenesis by ErbB/HER receptors.; ''Int J Radiat Oncol Biol Phys, 2004 - PubMed
  15. Scaltriti M, Baselga J; ''The epidermal growth factor receptor pathway: a model for targeted therapy.; ''Clin Cancer Res, 2006 - PubMed
  16. Holbro T, Hynes NE; ''ErbB receptors: directing key signaling networks throughout life.; ''Annu Rev Pharmacol Toxicol, 2004 - PubMed

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History

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CompareRevisionActionTimeUserComment
63184view20:44, 8 May 2013MaintBotUpdating gpml version
41091view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
38179view04:20, 22 August 2010AlexanderPicoConverted pathway objects
38178view04:16, 22 August 2010AlexanderPicoAdded literature references
38177view04:10, 22 August 2010AlexanderPicoConverted pathway objects
38176view04:01, 22 August 2010AlexanderPicoSpecify description
38175view03:59, 22 August 2010AlexanderPicoAdded reference and more EGFR connections
38174view03:49, 22 August 2010AlexanderPicoPeriodical save, work in progress
38173view03:39, 22 August 2010AlexanderPicoPeriodical save, work in progress
38172view03:28, 22 August 2010AlexanderPicoModified description
29836view10:01, 4 June 2009UomoamareAll nodes annotated through NCBI-GeneID
29835view09:56, 4 June 2009UomoamarePeriodical save, work in progress
29834view09:46, 4 June 2009UomoamarePeriodical save, work in progress
29833view09:35, 4 June 2009UomoamarePeriodical save, work in progress
29829view09:24, 4 June 2009UomoamarePeriodical save, work in progress
29738view22:34, 1 June 2009KhanspersModified categories
28873view15:02, 9 March 2009UomoamareSpecify description
28851view10:39, 8 March 2009UomoamareSpecify description
28828view13:45, 7 March 2009UomoamareModified description
28827view13:40, 7 March 2009Uomoamare1 revision
28826view13:36, 7 March 2009UomoamarePeriodical save, work in progress
28825view12:59, 7 March 2009UomoamarePeriodical save, work in progress
28824view12:48, 7 March 2009UomoamarePeriodical save, work in progress
28823view18:07, 6 March 2009UomoamarePeriodical save, work in progress
28822view18:04, 6 March 2009UomoamareSpecify description
28821view17:56, 6 March 2009UomoamareErbB Signaling Pathway
28820view17:53, 6 March 2009UomoamareErbB
28819view17:47, 6 March 2009UomoamarePeriodical save, work in progress
28818view17:36, 6 March 2009UomoamarePeriodical save, work in progress
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28816view16:35, 6 March 2009UomoamarePeriodical save, work in progress
28815view16:22, 6 March 2009UomoamareERBB SIGNALING PATHWAY
28814view16:20, 6 March 2009UomoamareSpecify description
28813view16:18, 6 March 2009UomoamareSpecify description
28812view16:13, 6 March 2009UomoamareSpecify description
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28810view16:05, 6 March 2009UomoamareSpecify description
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28807view15:55, 6 March 2009UomoamareSpecify description
28806view15:53, 6 March 2009UomoamarePeriodical save, work in progress
28805view15:52, 6 March 2009UomoamareSpecify description
28804view15:43, 6 March 2009UomoamarePeriodical save, work in progress
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External references

View all 47...

Name Type Database reference
SOS1GeneProduct6654 (Entrez Gene)
TGFAGeneProductENSG00000163235 (Ensembl)
EGFGeneProductENSG00000138798 (Ensembl)
AREGGeneProductENSG00000109321 (Ensembl)
PKB/AktGeneProduct207 (Entrez Gene)
BTCGeneProductENSG00000109321 (Ensembl)
JUNGeneProduct3725 (Entrez Gene)
HBEGFGeneProductENSG00000113070 (Ensembl)
ERKGeneProductENSG00000100030 (Ensembl)
EREGGeneProductENSG00000124882 (Ensembl)
p27GeneProduct1027 (Entrez Gene)
NRG1GeneProductENSG00000157168 (Ensembl)
JNKKGeneProduct6416 (Entrez Gene)
NRG2GeneProductENSG00000158458 (Ensembl)
SHC2GeneProduct25759 (Entrez Gene)
NRG3GeneProductENSG00000185737 (Ensembl)
RAFGeneProduct673 (Entrez Gene)
NRG4GeneProductENSG00000169752 (Ensembl)
GAB1GeneProduct2549 (Entrez Gene)
ERBB1GeneProduct1956 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
ERBB2GeneProductENSG00000141736 (Ensembl)
p70S6KGeneProduct6199 (Entrez Gene)
ERBB3GeneProductENSG00000065361 (Ensembl)
PAK1GeneProduct5058 (Entrez Gene)
ERBB4GeneProductENSG00000178568 (Ensembl)
JNKGeneProduct5599 (Entrez Gene)
PLCG1GeneProduct5335 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
CAMK2AGeneProduct815 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
RASGeneProductENSG00000174775 (Ensembl)
CBLCGeneProduct23624 (Entrez Gene)
MEKGeneProductENSG00000169032 (Ensembl)
STAT5AGeneProduct6776 (Entrez Gene)
MycGeneProduct4609 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
PI3KGeneProduct5290 (Entrez Gene)
FAKGeneProduct5747 (Entrez Gene)
mTORGeneProduct2475 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
GSK3GeneProduct2932 (Entrez Gene)
ABL1GeneProduct25 (Entrez Gene)
p21GeneProduct1026 (Entrez Gene)
NCK1GeneProduct4690 (Entrez Gene)
eIF-4EBPGeneProduct1978 (Entrez Gene)
Retrieved from "http://wikipathways.org/index.php/Pathway:WP673"
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