Statin Pathway (Homo sapiens)
Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism.
- Chen H, Ikeda U, Shimpo M, Shimada K; ''Direct effects of statins on cells primarily involved in atherosclerosis.; ''Hypertens Res, 2000 - PubMed
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|HDL||Metabolite||C01834 (Kegg Compound)|
|MIR33A||GeneProduct||ENSG00000207932 (Ensembl Human)|
|CYP7A1||GeneProduct||1581 (Entrez Gene)|
|SOAT1||GeneProduct||6646 (Entrez Gene)|