Wnt Signaling Pathway and Pluripotency (Homo sapiens)
This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal. A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components. Currently in the process of adding reference (please feel free to add to this).
View all 7 references
- Sato N, Brivanlou AH; ''Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor.; ''Methods Mol Biol, 2006 - PubMed
- Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.; ''Cell Death Differ, 2012 - PubMed
- Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M; ''Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.; ''Proc Natl Acad Sci U S A, 2007 - PubMed
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|TCF7L1||GeneProduct||83439 (Entrez Gene)|
|PPP2R3A||GeneProduct||5523 (Entrez Gene)|
|WNT2||GeneProduct||7472 (Entrez Gene)|
|CBP||GeneProduct||1387 (Entrez Gene)|
|WNT2B||GeneProduct||7482 (Entrez Gene)|