Ectoderm Differentiation (Homo sapiens)

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Revision as of 21:49, 6 May 2015 by Khanspers (Talk | contribs)
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Description

Model depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from: https://www.synapse.org/#!Synapse:syn1773109

Quality Tags

Ontology Terms

 

Bibliography

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  1. ''Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from embryonic stem cells.''; , PubMed
  2. ''Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development''; , PubMed
  3. ''Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells.''; , PubMed
  4. ''Beyond cell adhesion: the role of armadillo proteins in the heart.''; , PubMed
  5. ''Smurf1 regulates neural patterning and folding in Xenopus embryos by antagonizing the BMP/Smad1 pathway.''; , PubMed
  6. ''Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis''; , PubMed
  7. ''HESX1- and TCF3-mediated repression of Wnt/خ²-catenin targets is required for normal development of the anterior forebrain''; , PubMed
  8. Van Hateren, N., Shenton, T., Borycki, A.-G; ''Expression of avian C-terminal binding proteins (Ctbp1 and Ctbp2) during embryonic development ''; , 2006 PubMed
  9. ''Hedgehog and Gli signaling in embryonic mammary gland development.''; , PubMed

History

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CompareRevisionActionTimeUserComment
89329view09:53, 4 September 2016Mkutmonfix unconnected lines
87931view13:02, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
83015view13:26, 17 November 2015FehrhartUpdate of outdated identifiers
80104view21:49, 6 May 2015Khansperschanged color for miRNA nodes
80017view17:25, 30 April 2015ZariCorrected ID for BAZ1A,SKIL,ZBTB2,PIM1 ,MYC,LDB2,UBTF,HIST1H2BH,FHL2,BCOR
79851view03:37, 20 April 2015NsalomonisModified description
78578view14:50, 7 January 2015MaintBotadded missing graphIds
77751view05:03, 17 October 2014EgonwFixed two PubMed identifiers.
77745view20:49, 16 October 2014EgonwMade the PubMed identifiers proper numbers.
77686view03:48, 8 October 2014NsalomonisNew pathway

External references

Datanodes

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NameTypeDatabase referenceComment
ABCC4GeneProductENSG00000125257 (Ensembl)
AESGeneProductENSG00000104964 (Ensembl)
AHI1ENSG00000135541 (Ensembl)
ANKS1BGeneProductENSG00000185046 (Ensembl)
ARHGAP10ENSG00000071205 (Ensembl)
ARHGAP15ENSG00000075884 (Ensembl)
ARHGDIGGeneProductENSG00000242173 (Ensembl)
ARHGEF9ENSG00000131089 (Ensembl)
ARXGeneProductENSG00000004848 (Ensembl)
ASTN1GeneProductENSG00000152092 (Ensembl)
BAZ1AGeneProduct11177 (Entrez Gene)
BCAS3GeneProductENSG00000141376 (Ensembl)
BCORGeneProduct54880 (Entrez Gene)
BMP4ENSG00000125378 (Ensembl)
BMPR1AENSG00000107779 (Ensembl)
BOCENSG00000144857 (Ensembl)
C1GALT1GeneProductENSG00000106392 (Ensembl)
CAP2GeneProductENSG00000112186 (Ensembl)
CCDC130ENSG00000104957 (Ensembl)
CCDC88CENSG00000015133 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CDH6ENSG00000113361 (Ensembl)
CDH8ENSG00000150394 (Ensembl)
CDONENSG00000064309 (Ensembl)
CELSR2GeneProductENSG00000143126 (Ensembl)
CLDN11GeneProductENSG00000013297 (Ensembl)
CLVS1GeneProductENSG00000177182 (Ensembl)
CROCCP2GeneProductENSG00000215908 (Ensembl)
CTBP1ENSG00000159692 (Ensembl)
CTNNA2ENSG00000066032 (Ensembl)
CTNNB1ENSG00000168036 (Ensembl)
CTNND2ENSG00000169862 (Ensembl)
DMDGeneProductENSG00000198947 (Ensembl)
EDA2RENSG00000131080 (Ensembl)
EDAGeneProductENSG00000158813 (Ensembl)
EDAENSG00000158813 (Ensembl)
ELOVL2GeneProductENSG00000197977 (Ensembl)
ELOVL4GeneProductENSG00000118402 (Ensembl)
FGFR2ENSG00000066468 (Ensembl)
FHL2GeneProduct2274 (Entrez Gene)
FOXA2ENSG00000125798 (Ensembl)
FOXL1GeneProductENSG00000176678 (Ensembl)
FYNENSG00000010810 (Ensembl)
FZD4GeneProductENSG00000174804 (Ensembl)
FZD5GeneProductENSG00000163251 (Ensembl)
FZD8GeneProductENSG00000177283 (Ensembl)
GAS2L1GeneProductENSG00000185340 (Ensembl)
GATA6GeneProductENSG00000141448 (Ensembl)
GLB1GeneProductENSG00000170266 (Ensembl)
GLI3ENSG00000106571 (Ensembl)
GRAMD1BGeneProductENSG00000023171 (Ensembl)
GREB1GeneProductENSG00000196208 (Ensembl)
HDAC10ENSG00000100429 (Ensembl)
HDAC6ENSG00000094631 (Ensembl)
HESX1GeneProductENSG00000163666 (Ensembl)
HIST1H2BHGeneProduct8345 (Entrez Gene)
HMGB2ENSG00000164104 (Ensembl)
JAKMIP1GeneProductENSG00000152969 (Ensembl)
JUPENSG00000173801 (Ensembl)
KCNK10GeneProductENSG00000100433 (Ensembl)
KIAA1161GeneProductENSG00000164976 (Ensembl)
KIFC3GeneProductENSG00000140859 (Ensembl)
KRT6AENSG00000205420 (Ensembl)
LDB2GeneProduct9079 (Entrez Gene)
LHX1ENSG00000132130 (Ensembl)
LY6EGeneProductENSG00000160932 (Ensembl)
MAFBGeneProductENSG00000204103 (Ensembl)
MECP2GeneProductENSG00000169057 (Ensembl)
MIR124-1GeneProductENSG00000208010 (Ensembl)
MIR15BGeneProductENSG00000207779 (Ensembl)
MIR34CGeneProductENSG00000207562 (Ensembl)
MIR361GeneProductENSG00000199051 (Ensembl)
MIR486GeneProductENSG00000221035 (Ensembl)
MKS1ENSG00000011143 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
MZF1GeneProductENSG00000099326 (Ensembl)
NARS2GeneProductENSG00000137513 (Ensembl)
NF2ENSG00000186575 (Ensembl)
NFATC1GeneProductENSG00000131196 (Ensembl)
NLGN1ENSG00000169760 (Ensembl)
NLKGeneProductENSG00000087095 (Ensembl)
NR2F2ENSG00000185551 (Ensembl)
NUMA1ENSG00000137497 (Ensembl)
OGTENSG00000147162 (Ensembl)
PAN2ENSG00000135473 (Ensembl)
PAX3ENSG00000135903 (Ensembl)
PAX6ENSG00000007372 (Ensembl)
PDE7AENSG00000205268 (Ensembl)
PGM1GeneProductENSG00000079739 (Ensembl)
PHF8GeneProductENSG00000172943 (Ensembl)
PI4KAGeneProductENSG00000241973 (Ensembl)
PIM1GeneProduct5292 (Entrez Gene)
PLCXD3GeneProductENSG00000182836 (Ensembl)
PLXNA2GeneProductENSG00000076356 (Ensembl)
PODXLGeneProductENSG00000128567 (Ensembl)
POU2F2GeneProductENSG00000028277 (Ensembl)
PPARDENSG00000112033 (Ensembl)
PPFIBP2GeneProductENSG00000166387 (Ensembl)
PRKAG2GeneProductENSG00000106617 (Ensembl)
PTPN13ENSG00000163629 (Ensembl)
PTPRBGeneProductENSG00000127329 (Ensembl)
RAB8BENSG00000166128 (Ensembl)
RGMAGeneProductENSG00000182175 (Ensembl)
RHPN1GeneProductENSG00000158106 (Ensembl)
RIT1ENSG00000143622 (Ensembl)
ROR2GeneProductENSG00000169071 (Ensembl)
RRBP1GeneProductENSG00000125844 (Ensembl)
SCHIP1ENSG00000151967 (Ensembl)
SDCBPENSG00000137575 (Ensembl)
SERPINB6GeneProductENSG00000124570 (Ensembl)
SGSM3ENSG00000100359 (Ensembl)
SHHENSG00000164690 (Ensembl)
SIX6GeneProductENSG00000184302 (Ensembl)
SKILGeneProduct6498 (Entrez Gene)
SMAD4GeneProductENSG00000141646 (Ensembl)
SMURF1ENSG00000198742 (Ensembl)
SNCAENSG00000145335 (Ensembl)
SOCS2GeneProductENSG00000120833 (Ensembl)
SORCS1GeneProductENSG00000108018 (Ensembl)
SOX2GeneProductENSG00000181449 (Ensembl)
SPRY2GeneProductENSG00000136158 (Ensembl)
ST8SIA4GeneProductENSG00000113532 (Ensembl)
STC1GeneProductENSG00000159167 (Ensembl)
STX16GeneProductENSG00000124222 (Ensembl)
TBL1XENSG00000101849 (Ensembl)
TCF3ENSG00000071564 (Ensembl)
TCF7L1GeneProductENSG00000152284 (Ensembl)
TFAP2AGeneProductENSG00000137203 (Ensembl)
TFAP2CGeneProductENSG00000087510 (Ensembl)
TNFRSF11BGeneProductENSG00000164761 (Ensembl)
TOX3GeneProductENSG00000103460 (Ensembl)
TRIM33GeneProductENSG00000197323 (Ensembl)
TRPM2GeneProductENSG00000142185 (Ensembl)
TSC22D1ENSG00000102804 (Ensembl)
TSKUGeneProductENSG00000182704 (Ensembl)
TTC14ENSG00000163728 (Ensembl)
UBTFGeneProduct7343 (Entrez Gene)
VAX2ENSG00000116035 (Ensembl)
WDR44GeneProductENSG00000131725 (Ensembl)
WNT1ENSG00000125084 (Ensembl)
ZBTB16ENSG00000109906 (Ensembl)
ZBTB2GeneProduct57621 (Entrez Gene)
ZBTB7BENSG00000160685 (Ensembl)
ZFHX4GeneProductENSG00000091656 (Ensembl)
ZNF219GeneProductENSG00000165804 (Ensembl)

Annotated Interactions

No annotated interactions

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