One Carbon Metabolism (Homo sapiens)

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Contents



Curation Tags

Description

This one-carbon metabolism pathway is centered around folate. Folate is the primary methyl-group donor for processes such as DNA methylation reactions, nucleotide synthesis and

DNA repair mechanisms. An important pathway for any study related to folate or DNA methylation.

Differential methylation (e.g. hypermethylation of tumor suppressors) as well as disturbances in nucleotide synthesis and repair, are associated with several forms of cancer. There are also indications that hypermethylation is involved in the progression of adenomas to cancer.

Ontology Tags

 

Bibliography

  1. Ludwig ML, Matthews RG; ''Structure-based perspectives on B12-dependent enzymes.; ''Annu Rev Biochem, 1997 - PubMed
  2. Hazra A, Wu K, Kraft P, Fuchs CS, Giovannucci EL, Hunter DJ; ''Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and riskof colorectal adenoma in the Nurses' Health Study.; ''Carcinogenesis, 2007 - PubMed

Categories


History

View all
CompareRevisionActionTimeUserComment
61699view23:32, 16 April 2013MaintBotupdated data node type "Unkown" to "GeneProduct" for annotated genes
49064view08:35, 4 July 2012Eveloimproved homocysteine annotatopn
45325view20:12, 7 October 2011KhanspersOntology Term : 'folate mediated one-carbon metabolic pathway' added !
41078view23:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
38794view06:48, 24 September 2010Thomaslinked to dna repair pathways
36799view12:04, 4 May 2010EveloMTHFR Riboflavin complex
36797view11:56, 4 May 2010EveloModified description
36795view11:38, 4 May 2010EveloAdded MTR reference
36794view11:29, 4 May 2010EveloModified description
36793view11:12, 4 May 2010EveloAdded more vitamins as metabolites, multiline labels
36792view10:28, 4 May 2010EveloAdded vitamin names to metabolite labels
36779view09:04, 4 May 2010Eveloadded connection
36699view12:09, 16 April 2010MichielMinor edits
36698view12:07, 16 April 2010MichielMinor cleanup
36697view12:03, 16 April 2010MichielAdded metabolites
36696view12:00, 16 April 2010MichielCorrected Cobalamin
36695view11:58, 16 April 2010MichielCorrected reactions
36689view11:08, 15 April 2010Evelocorrected typos in metabolite names
36181view14:36, 5 March 2010EveloPeriodical save, work in progress
35855view17:59, 18 February 2010AlexanderPicotest
34894view00:30, 3 February 2010AlexanderPicoModified description
32642view14:39, 24 August 2009Eveloalignment
32010view13:19, 14 August 2009MaintBotFixed group labels
21183view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:One-carbon metabolism]] moved to [[Pathway:WP241]]: Moved to stable identifier
20613view12:44, 12 November 2008Thomasfixed duplicate literature reference
15833view13:34, 5 June 2008EgoyenecheaPeriodical save, work in progress
15301view11:31, 27 May 2008Michielanchors
15218view07:50, 26 May 2008MichielAnchor correction
14657view14:13, 23 May 2008Michielcu
14654view14:08, 23 May 2008MichielCleaned up
14652view14:07, 23 May 2008MichielConnected all genes to reaction arrows
14649view13:55, 23 May 2008MichielSpecify description
14647view13:34, 23 May 2008MichielConnected genes to reaction arrows
14645view13:28, 23 May 2008MichielConnected some genes to reactions
14643view13:13, 23 May 2008MichielCleaned up some more
14641view13:09, 23 May 2008MichielCleaned up
14639view13:08, 23 May 2008MichielCorrected arrows
14637view13:07, 23 May 2008MichielCurated: grouped genes, arrows connected, cleaned up
12494view10:52, 15 May 2008MichielPeriodical save, work in progress
12488view10:43, 15 May 2008MichielCurved arrow enhancements #1
11556view01:22, 11 April 2008Txr24Modified description
11555view01:19, 11 April 2008Txr24Modified description
11554view00:53, 11 April 2008Txr24fosfaat -> phosphate
8308view13:46, 7 January 2008MaintBot[[Pathway:Human:One-carbon metabolism]] moved to [[Pathway:Homo sapiens:One-carbon metabolism]]: Renaming species
7559view11:46, 18 December 2007Thomasadded to metabolic category
7554view08:56, 18 December 2007MichielUpdated description
7553view08:51, 18 December 2007MichielAdded description
7156view20:40, 30 October 2007FrankDots on the I
7155view20:08, 30 October 2007FrankAdded some missing genes, blue metabolites
7152view13:02, 26 October 2007FrankAdded most CAS numbers

External references

View all 40...

Name Type Database reference
10-Formyl TetrahydrofolateMetabolite2800-34-2 (CAS)
MAT2BUnknown27430 (Entrez Gene)
SHMT1Unknown6470 (Entrez Gene)
SHMT2Unknown6472 (Entrez Gene)
ALDH1L1Unknown10840 (Entrez Gene)
TetrahydrofolateMetabolite135-16-0 (CAS)
TCN IIUnknown6948 (Entrez Gene)
S-AdenosylmethionineMetabolite29908-03-0 (CAS)
MTHFRUnknown4524 (Entrez Gene)
AHCYUnknown191 (Entrez Gene)
BHMTUnknown635 (Entrez Gene)
PolyglutamateMetabolite25513-46-6 (CAS)
DNMT1Unknown1786 (Entrez Gene)
5,10-Methylene TetrahydrofolateMetabolite25513-46-6 (CAS)
MTRUnknown4548 (Entrez Gene)
MethionineMetabolite63-68-3 (CAS)
MTRRUnknown4552 (Entrez Gene)
HomocysteineMetabolite6027-13-0 (CAS)
MTHFD1Unknown4522 (Entrez Gene)
FOLH1Unknown2346 (Entrez Gene)
GARTUnknown2618 (Entrez Gene)
KIAA0828Unknown23382 (Entrez Gene)
ATICUnknown471 (Entrez Gene)
MAT1AUnknown4143 (Entrez Gene)
DHFRUnknown1719 (Entrez Gene)
MonoglutamateMetabolite59-30-3 (CAS)
MTHFD1LUnknown25902 (Entrez Gene)
DihydrofolateMetabolite4033-27-6 (CAS)
MTFMTUnknown123263 (Entrez Gene)
5-Methyl TetrahydrofolateMetabolite134-35-0 (CAS)
DNMT3aUnknown1788 (Entrez Gene)
5,10-Methenyl TetrahydrofolateMetabolite7444-29-3 (CAS)
DNMT3bUnknown1789 (Entrez Gene)
BetaineMetabolite107-43-7 (CAS)
MTHFD2Unknown10797 (Entrez Gene)
S-adenosylhomocysteineMetabolite979-92-0 (CAS)
FTCDUnknown10841 (Entrez Gene)
AMTUnknown275 (Entrez Gene)
MTHFSUnknown10588 (Entrez Gene)
TYMSUnknown7298 (Entrez Gene)
Retrieved from "http://wikipathways.org/index.php/Pathway:WP241"
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