One Carbon Metabolism (Homo sapiens)
The folate pathway is central to any study related to DNA methylation, dTMP synthesis or purine synthesis.
Differential methylation (e.g. hypermethylation of tumor suppressors) as well as disturbances in nucleotide synthesis and repair, are associated with several forms of cancer. There are also indications that hypermethylation is involved in the progression of adenomas to cancer.
The pathway is also illustrative of the role of a number of B vitamins, including vitamin B12 (cobalamine) which is important for the sythesis of folate (vitamin B9) and of methionine.
- Ludwig ML, Matthews RG; ''Structure-based perspectives on B12-dependent enzymes.; ''Annu Rev Biochem, 1997 - PubMed
- Hazra A, Wu K, Kraft P, Fuchs CS, Giovannucci EL, Hunter DJ; ''Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and riskof colorectal adenoma in the Nurses' Health Study.; ''Carcinogenesis, 2007 - PubMed
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|5,10-Methenyl Tetrahydrofolate||Metabolite||7444-29-3 (CAS)|
|SHMT1||6470 (Entrez Gene)|
|Non-homologous end joining||Pathway||WP438 (WikiPathways)|
|ALDH1L1||10840 (Entrez Gene)|
|TYMS||7298 (Entrez Gene)|