Neural Crest Differentiation (Homo sapiens)

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Contents



Curation Tags

Description

Gene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involved involved in neural crest and downstream progenitor specification. Transcriptional regulation arrows are proposed to promote transcription, unless a graphical T-bar is present at the end of the arrow (commented to be inhibitors of transcriptional regulation). Additional gene information was obtained from http://www.ncbi.nlm.nih.gov/books/NBK53143

Ontology Tags

 

Bibliography

View all 10 references
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Categories


History

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CompareRevisionActionTimeUserComment
59181view18:44, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
47071view00:00, 15 March 2012KhanspersModified categories
45837view05:53, 17 November 2011NsalomonisAdded other implicated genes
45836view05:51, 17 November 2011NsalomonisSpecify description
45835view05:40, 17 November 2011NsalomonisPeriodical save, work in progress
45834view05:30, 17 November 2011NsalomonisPeriodical save, work in progress
45833view05:17, 17 November 2011NsalomonisPeriodical save, work in progress
45832view04:51, 17 November 2011NsalomonisPeriodical save, work in progress
45831view01:01, 17 November 2011NsalomonisSpecify description
45830view01:01, 17 November 2011NsalomonisSpecify description
45829view00:43, 17 November 2011NsalomonisPeriodical save, work in progress
45633view23:18, 25 October 2011NsalomonisModified description
45584view20:45, 17 October 2011NsalomonisOntology Term : 'neuron neural crest derived' added !
45583view20:45, 17 October 2011NsalomonisOntology Term : 'regulatory pathway' added !
45582view20:44, 17 October 2011NsalomonisOntology Term : 'cranial neural crest cell' added !
45581view20:43, 17 October 2011NsalomonisModified description
45580view18:38, 17 October 2011NsalomonisModified description
45579view18:31, 17 October 2011NsalomonisPeriodical save, work in progress
45578view18:24, 17 October 2011NsalomonisSpecify description
45577view18:21, 17 October 2011NsalomonisPeriodical save, work in progress
45576view18:00, 17 October 2011NsalomonisSpecify description
45575view17:55, 17 October 2011NsalomonisSpecify description
45574view17:50, 17 October 2011NsalomonisPeriodical save, work in progress
45573view17:40, 17 October 2011NsalomonisPeriodical save, work in progress
45567view06:15, 17 October 2011NsalomonisSpecify description
45566view06:11, 17 October 2011NsalomonisModified description
45565view06:06, 17 October 2011NsalomonisSpecify description
45564view06:06, 17 October 2011NsalomonisSpecify description
45563view06:03, 17 October 2011NsalomonisPeriodical save, work in progress
45562view05:45, 17 October 2011NsalomonisSpecify description
45561view05:43, 17 October 2011NsalomonisPeriodical save, work in progress
45560view05:21, 17 October 2011NsalomonisSpecify description
45559view05:13, 17 October 2011NsalomonisPeriodical save, work in progress
45558view05:09, 17 October 2011NsalomonisSpecify description
45557view05:01, 17 October 2011NsalomonisSpecify description
45556view04:56, 17 October 2011NsalomonisPeriodical save, work in progress
45555view04:46, 17 October 2011NsalomonisPeriodical save, work in progress
45554view04:36, 17 October 2011NsalomonisPeriodical save, work in progress
45553view04:26, 17 October 2011NsalomonisPeriodical save, work in progress
45552view04:23, 17 October 2011NsalomonisSpecify description
45551view04:16, 17 October 2011NsalomonisPeriodical save, work in progress
45550view04:05, 17 October 2011NsalomonisPeriodical save, work in progress
45549view03:55, 17 October 2011NsalomonisPeriodical save, work in progress
45548view03:53, 17 October 2011NsalomonisSpecify description
45547view03:45, 17 October 2011NsalomonisPeriodical save, work in progress
45546view03:36, 17 October 2011NsalomonisSpecify description
45545view03:35, 17 October 2011NsalomonisPeriodical save, work in progress
45544view03:31, 17 October 2011NsalomonisSpecify description
45543view03:24, 17 October 2011NsalomonisPeriodical save, work in progress
45542view03:17, 17 October 2011NsalomonisSpecify description

External references

View all 91...

Name Type Database reference
OLIG1GeneProductENSG00000184221 (Ensembl Human)
BMP7GeneProductENSG00000101144 (Ensembl Human)
FGFR3GeneProductENSG00000068078 (Ensembl Human)
RHOBGeneProductENSG00000143878 (Ensembl Human)
HDAC5GeneProductENSG00000108840 (Ensembl Human)
MYBGeneProductENSG00000118513 (Ensembl Human)
SOX5GeneProductENSG00000134532 (Ensembl Human)
ITGB1GeneProductENSG00000150093 (Ensembl Human)
LHX1GeneProductENSG00000132130 (Ensembl Human)
WNT1GeneProductENSG00000125084 (Ensembl Human)
DCTGeneProductENSG00000080166 (Ensembl Human)
TFAP2AGeneProductENSG00000137203 (Ensembl Human)
ISL1GeneProductENSG00000016082 (Ensembl Human)
ZIC1GeneProductENSG00000152977 (Ensembl Human)
NFKB2GeneProductENSG00000077150 (Ensembl Human)
PAX3GeneProductENSG00000135903 (Ensembl Human)
MITFGeneProductENSG00000187098 (Ensembl Human)
PAX7GeneProductENSG00000009709 (Ensembl Human)
HDAC1GeneProductENSG00000116478 (Ensembl Human)
DLX5GeneProductENSG00000105880 (Ensembl Human)
HDAC9GeneProductENSG00000048052 (Ensembl Human)
MSX1GeneProductENSG00000163132 (Ensembl Human)
DifferentiationPathway
MSX2GeneProductENSG00000120149 (Ensembl Human)
MYCGeneProductENSG00000136997 (Ensembl Human)
FOXD3GeneProductENSG00000187140 (Ensembl Human)
CDH2GeneProductENSG00000170558 (Ensembl Human)
SNAI1GeneProductENSG00000124216 (Ensembl Human)
NFKB1GeneProductENSG00000109320 (Ensembl Human)
SNAI2GeneProductENSG00000019549 (Ensembl Human)
PHOX2BGeneProductENSG00000109132 (Ensembl Human)
WNT3AGeneProductENSG00000154342 (Ensembl Human)
GJB1GeneProductENSG00000169562 (Ensembl Human)
FZD3GeneProductENSG00000104290 (Ensembl Human)
MPZGeneProductENSG00000158887 (Ensembl Human)
GSK3BGeneProductENSG00000082701 (Ensembl Human)
FGF8GeneProductENSG00000107831 (Ensembl Human)
CTNNB1GeneProductENSG00000168036 (Ensembl Human)
HDAC3GeneProductENSG00000171720 (Ensembl Human)
TCF7L1GeneProductENSG00000152284 (Ensembl Human)
HDAC7GeneProductENSG00000061273 (Ensembl Human)
TCF4GeneProductENSG00000196628 (Ensembl Human)
HDAC11GeneProductENSG00000163517 (Ensembl Human)
GBX2GeneProductENSG00000168505 (Ensembl Human)
COL11A2GeneProductENSG00000204248 (Ensembl Human)
AXIN2GeneProduct8313 (Entrez Gene)
FGFR2GeneProductENSG00000066468 (Ensembl Human)
AXIN1GeneProduct8312 (Entrez Gene)
ZIC5GeneProductENSG00000139800 (Ensembl Human)
DVL3GeneProduct1857 (Entrez Gene)
SOX9GeneProductENSG00000125398 (Ensembl Human)
DVL2GeneProduct1856 (Entrez Gene)
CDH6GeneProductENSG00000113361 (Ensembl Human)
DVL1GeneProduct1855 (Entrez Gene)
CDH1GeneProductENSG00000039068 (Ensembl Human)
BMP4GeneProductENSG00000125378 (Ensembl Human)
ETS1GeneProductENSG00000134954 (Ensembl Human)
SMAD1GeneProductENSG00000170365 (Ensembl Human)
CDH7GeneProductENSG00000081138 (Ensembl Human)
ID1GeneProductENSG00000125968 (Ensembl Human)
NEUROG1GeneProductENSG00000181965 (Ensembl Human)
NOTCH1GeneProductENSG00000148400 (Ensembl Human)
GFAPGeneProductENSG00000131095 (Ensembl Human)
DLL3GeneProductENSG00000090932 (Ensembl Human)
OLIG2GeneProductENSG00000205927 (Ensembl Human)
NOTCH4GeneProductENSG00000204301 (Ensembl Human)
ASCL1GeneProductENSG00000139352 (Ensembl Human)
NOTCH2GeneProductENSG00000134250 (Ensembl Human)
PMP22GeneProductENSG00000109099 (Ensembl Human)
DLL4GeneProductENSG00000128917 (Ensembl Human)
MBPGeneProductENSG00000197971 (Ensembl Human)
NOTCH3GeneProductENSG00000074181 (Ensembl Human)
LHX2GeneProductENSG00000106689 (Ensembl Human)
DLL1GeneProductENSG00000198719 (Ensembl Human)
FGF19GeneProductENSG00000162344 (Ensembl Human)
HEY2GeneProductENSG00000135547 (Ensembl Human)
HDAC2GeneProductENSG00000196591 (Ensembl Human)
TWIST1GeneProductENSG00000122691 (Ensembl Human)
HDAC4GeneProductENSG00000068024 (Ensembl Human)
SOX10GeneProductENSG00000100146 (Ensembl Human)
HDAC6GeneProductENSG00000094631 (Ensembl Human)
FGF2GeneProductENSG00000138685 (Ensembl Human)
HDAC8GeneProductENSG00000147099 (Ensembl Human)
HES5GeneProductENSG00000197921 (Ensembl Human)
HDAC10GeneProductENSG00000100429 (Ensembl Human)
HES1GeneProductENSG00000114315 (Ensembl Human)
CTBP2GeneProductENSG00000175029 (Ensembl Human)
RBPJGeneProductENSG00000168214 (Ensembl Human)
COL2A1GeneProductENSG00000139219 (Ensembl Human)
FGFR1GeneProductENSG00000077782 (Ensembl Human)
MIAGeneProduct8190 (Entrez Gene)
Retrieved from "http://wikipathways.org/index.php/Pathway:WP2064"
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