Thyroxine (thyroid hormone) production (Homo sapiens)
Thyroxine hormone is produced in the thyroid gland from tyrosine and iodine. Thyrotropin-releasing hormone (TRH) is produced by the hypothalamus. It stimulates the production of thyroid-stimulating hormone (TSH) in the anterior pituitary gland, which affects the thyroid-stimulating hormone receptor (TSHR). Iodine is captured by a hydrogen peroxide trap procuced by thyroid peroxidase and added to the 3' and 5' postitions of tyrosine. This can either be free tyrosine or a tyrosine residue in thyroglobuline. After the multiple iodination steps this produces T3 and T4.
- Ron E, Lubin JH, Shore RE, Mabuchi K, Modan B, Pottern LM, Schneider AB, Tucker MA, Boice JD Jr; ''Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies.; ''Radiat Res, 1995 - PubMed
- Van Herle, A.J ., G. Vassart, J.E . Dumont; ''Control of thyroglobulin synthesis and secretion; ''N. Engl. J. Med. 301:239, 1979 - PubMed
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|TRH||GeneProduct||7200 (Entrez Gene)|
|127 Iodide||Metabolite||HMDB12238 (HMDB)|
|Thyroxine (T4)||Metabolite||HMDB00248 (HMDB)|
|Thyroidperoxidase||GeneProduct||7173 (Entrez Gene)|