Thyroxine (thyroid hormone) production (Homo sapiens)

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Curation Tags

Description

Thyroxine hormone is produced in the thyroid gland from tyrosine and iodine. Thyrotropin-releasing hormone (TRH) is produced by the hypothalamus. It stimulates the production of thyroid-stimulating hormone (TSH) in the anterior pituitary gland, which affects the thyroid-stimulating hormone receptor (TSHR). Iodine is captured by a hydrogen peroxide trap procuced by thyroid peroxidase and added to the 3' and 5' postitions of tyrosine. This can either be free tyrosine or a tyrosine residue in thyroglobuline. After the multiple iodination steps this produces T3 and T4.

Ontology Tags

 

Bibliography

  1. Ron E, Lubin JH, Shore RE, Mabuchi K, Modan B, Pottern LM, Schneider AB, Tucker MA, Boice JD Jr; ''Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies.; ''Radiat Res, 1995 - PubMed
  2. Van Herle, A.J ., G. Vassart, J.E . Dumont; ''Control of thyroglobulin synthesis and secretion; ''N. Engl. J. Med. 301:239, 1979 - PubMed

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History

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CompareRevisionActionTimeUserComment
54373view15:18, 28 November 2012Mkutmonadded some labels and ioniation error
54372view15:10, 28 November 2012EveloModified description
54371view15:07, 28 November 2012EveloModified description
54364view14:51, 28 November 2012Mkutmonupdated MIM interactions
44968view13:21, 6 October 2011Mkutmonconnected lines
44471view20:38, 14 September 2011MaintBotAdded category
42772view17:05, 29 April 2011LribeiroPeriodical save, work in progress
42771view16:40, 29 April 2011LribeiroModified description
42770view15:39, 29 April 2011LribeiroModified description
42756view18:43, 28 April 2011LribeiroPeriodical save, work in progress
42755view18:32, 28 April 2011LribeiroPeriodical save, work in progress
42754view18:22, 28 April 2011LribeiroPeriodical save, work in progress
42742view19:56, 26 April 2011LribeiroPeriodical save, work in progress
42741view19:46, 26 April 2011LribeiroPeriodical save, work in progress
42740view19:36, 26 April 2011LribeiroPeriodical save, work in progress
42413view09:03, 23 March 2011EveloConnected some hormone interaction
42299view20:50, 14 March 2011EveloPeriodical save, work in progress
42298view20:04, 14 March 2011EveloAdded iodide symporter
42297view19:54, 14 March 2011EveloPeriodical save, work in progress
42296view19:24, 14 March 2011EveloOntology Term : 'thyroid hormone signaling pathway' added !
42295view19:22, 14 March 2011EveloOntology Term : 'thyroid gland disease' added !
42287view13:15, 14 March 2011EveloAdded organs
42286view12:43, 14 March 2011MkutmonCorrection of the name
42281view22:04, 13 March 2011EveloModified description
42280view22:00, 13 March 2011EveloSpecify description
42279view21:54, 13 March 2011EveloAdded TPO
42278view21:44, 13 March 2011EveloAdded Thyroglobulin
42277view21:26, 13 March 2011EveloModified description
42276view21:17, 13 March 2011EveloModified description
42275view21:11, 13 March 2011EveloSpecify description
42274view21:01, 13 March 2011EveloPeriodical save, work in progress
42273view20:49, 13 March 2011EveloAdde tyrosine
42272view20:36, 13 March 2011EveloAdded T3 (from ChemSpider!)
42271view20:31, 13 March 2011EveloPeriodical save, work in progress
42270view20:26, 13 March 2011Evelofirst edit added thyroxine
42269view18:21, 13 March 2011AndraCreated stub
42268view18:14, 13 March 2011AndraNew pathway

External references

View all 11...

Name Type Database reference
TRHGeneProduct7200 (Entrez Gene)
127 IodideMetaboliteHMDB12238 (HMDB)
131 IodideMetabolite
Thyroxine (T4)MetaboliteHMDB00248 (HMDB)
ThyroidperoxidaseGeneProduct7173 (Entrez Gene)
Triiodothyronine (T3)Metabolite5707 (Chemspider)
TSHGeneProduct1081 (Entrez Gene)
L-TyrosineMetaboliteHMDB00158 (HMDB)
ThyroglobulinGeneProduct7038 (Entrez Gene)
TSHRGeneProduct7253 (Entrez Gene)
SLC5A5GeneProduct6528 (Entrez Gene)
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