Cholesterol biosynthesis (Homo sapiens)

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GenMAPP notes 
References: Bard, M., Bruner, D. A., Pierson, C. A., Lees, N. D., Biermann, B., Frye, L., Koegel, C., and Barbuch, R. (1996). Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase. Proc Natl Acad Sci U S A 93, 186-190.

Gaylor, J. L. (2002). Membrane-bound enzymes of cholesterol synthesis from lanosterol. Biochem Biophys Res Commun 292, 1139-1146.
Li, L., and Kaplan, J. (1996). Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue. J Biol Chem 271, 16927-16933.
Liu, X. Y., Dangel, A. W., Kelley, R. I., Zhao, W., Denny, P., Botcherby, M., Cattanach, B., Peters, J., Hunsicker, P. R., Mallon, A. M., et al. (1999). The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase. Nat Genet 22, 182-187.
Ohashi, M., Mizushima, N., Kabeya, Y., and Yoshimori, T. (2003). Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets. J Biol Chem 278, 36819-36829.
Sagami, H., Korenaga, T., and Ogura, K. (1993). Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate. J Biochem (Tokyo) 114, 118-121.
Yoshida, Y., Noshiro, M., Aoyama, Y., Kawamoto, T., Horiuchi, T., and Gotoh, O. (1997). Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: II. Evolutionary analysis of protein and gene structures. J Biochem (Tokyo) 122, 1122-1128.

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CompareRevisionActionTimeUserComment
63163view20:24, 8 May 2013MaintBotUpdating gpml version
59219view20:13, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
59147view03:03, 22 February 2013MaintBotModified title
44991view14:36, 6 October 2011MartijnVanIerselOntology Term : 'cholesterol biosynthetic pathway' added !
43562view21:55, 29 June 2011Samuel SklarSREBP added
41229view23:46, 1 March 2011MaintBotRemoved redundant pathway information and comments
35133view13:55, 11 February 2010ThomasModified description
35132view13:53, 11 February 2010Thomasremoved genmapp comments
35131view13:52, 11 February 2010Thomasadded references
34473view18:34, 10 December 2009MaintBotAutomatic update of empty xrefs
31995view13:15, 14 August 2009MaintBotFixed group labels
21093view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Cholesterol Biosynthesis]] moved to [[Pathway:WP197]]: Moved to stable identifier
14362view15:13, 22 May 2008Pahlesfor some metabolites the type was unknown
14346view13:51, 22 May 2008Pahlesreactions connected
14344view13:40, 22 May 2008PahlesPeriodical save, work in progress
14338view13:29, 22 May 2008Pahlesmetabolites added
14336view13:28, 22 May 2008PahlesPeriodical save, work in progress
14329view13:18, 22 May 2008PahlesPeriodical save, work in progress
14324view13:08, 22 May 2008PahlesPeriodical save, work in progress
14318view12:57, 22 May 2008PahlesPeriodical save, work in progress
13048view11:11, 17 May 2008MaintBotautomated metabolite conversion
7954view13:46, 7 January 2008MaintBot[[Pathway:Human:Cholesterol Biosynthesis]] moved to [[Pathway:Homo sapiens:Cholesterol Biosynthesis]]: Renaming species
7601view16:03, 18 December 2007MaintBotfixed category names
7334view12:42, 4 November 2007MaintBotAdded categories to GPML
19405view22:17, 22 May 2007N.Manteigpml file for [[Human:Cholesterol_Biosynthesis]]
6302view22:17, 22 May 2007M.Liebermangpml file for [[Human:Cholesterol_Biosynthesis]]

External references

View all 30...

Name Type Database reference
FDPSGeneProduct2224 (Entrez Gene)
Mevalonic acid 5-pyrophosphateMetabolite1492-08-6 (CAS)
IDI1GeneProduct3422 (Entrez Gene)
CholesterolMetabolite57-88-5 (CAS)
HMGCS1GeneProduct3157 (Entrez Gene)
7-DehydrocholesterolMetabolite434-16-2 (CAS)
HMGCRGeneProduct3156 (Entrez Gene)
SqualeneMetabolite111-02-4 (CAS)
MVKGeneProduct4598 (Entrez Gene)
Mevalonic acidMetabolite150-97-0 (CAS)
MVDGeneProduct4597 (Entrez Gene)
Geranyl-PPMetabolite6699-20-3 (CAS)
FDFT1GeneProduct2222 (Entrez Gene)
(S)-2,3-EpoxysqualeneMetabolite9029-62-3 (CAS)
DHCR7GeneProduct1717 (Entrez Gene)
Acetyl-CoAMetabolite72-89-9 (CAS)
SC5DLGeneProduct6309 (Entrez Gene)
LathosterolMetabolite80-99-9 (CAS)
LSSGeneProduct4047 (Entrez Gene)
HMG-CoAMetabolite (CAS)
SQLEGeneProduct6713 (Entrez Gene)
Mevalonic acid-5PMetabolite73566-35-5 (CAS)
PMVKGeneProduct10654 (Entrez Gene)
farnesyl pyrophosphateMetabolite13058-04-3 (CAS)
NSDHLGeneProduct50814 (Entrez Gene)
DimethylallylpyrophosphateMetabolite358-72-5 (CAS)
CYP51A1GeneProduct1595 (Entrez Gene)
LanosterinMetabolite79-63-0 (CAS)
SC4MOLGeneProduct6307 (Entrez Gene)
isopentenyl pyrophosphateMetabolite358-71-4 (CAS)
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