MicroRNAs in cardiomyocyte hypertrophy (Mus musculus)

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Contents



Curation Tags

Description

This pathway shows the role of microRNAs in the process of cardiac hypertrophy.

Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red, dashed lines. MicroRNAs are shown as purple rounded rectangles.

It is not sure which WNT and frizzled proteins influence cardiac hypertrophy. Though there are strong indications that WNT3A, WNT5A, frizzled1 and frizzled2 play a role in cardiac hypertrophy. Thus these have been added to the pathway instead of all the WNT and frizzled proteins. Experiments which will shed light on this are still being done.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1544(r37553) with a 96% conversion rate.

Ontology Tags

 

Bibliography

View all 17 references
  1. Takeishi Y, Ping P, Bolli R, Kirkpatrick DL, Hoit BD, Walsh RA; ''Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy.; ''Circ Res, 2000 - PubMed
  2. Clerk A, Sugden PH; ''Small guanine nucleotide-binding proteins and myocardial hypertrophy.; ''Circ Res, 2000 - PubMed
  3. Blankesteijn WM, van de Schans VA, ter Horst P, Smits JF; ''The Wnt/frizzled/GSK-3 beta pathway: a novel therapeutic target for cardiac hypertrophy.; ''Trends Pharmacol Sci, 2008 - PubMed
  4. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN; ''A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.; ''Cell, 1998 - PubMed
  5. Jalili T, Takeishi Y, Walsh RA; ''Signal transduction during cardiac hypertrophy: the role of G alpha q, PLC beta I, and PKC.; ''Cardiovasc Res, 1999 - PubMed
  6. Molkentin JD; ''Calcineurin and beyond: cardiac hypertrophic signaling.; ''Circ Res, 2000 - PubMed
  7. Carè A, Catalucci D, Felicetti F, Bonci D, Addario A, Gallo P, Bang ML, Segnalini P, Gu Y, Dalton ND, Elia L, Latronico MV, Høydal M, Autore C, Russo MA, Dorn GW 2nd, Ellingsen O, Ruiz-Lozano P, Peterson KL, Croce CM, Peschle C, Condorelli G; ''MicroRNA-133 controls cardiac hypertrophy.; ''Nat Med, 2007 - PubMed
  8. Wollert KC, Taga T, Saito M, Narazaki M, Kishimoto T, Glembotski CC, Vernallis AB, Heath JK, Pennica D, Wood WI, Chien KR; ''Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways.; ''J Biol Chem, 1996 - PubMed
  9. Lim HW, Molkentin JD; ''Calcineurin and human heart failure.; ''Nat Med, 1999 - PubMed
  10. Vanhaesebroeck B, Alessi DR; ''The PI3K-PDK1 connection: more than just a road to PKB.; ''Biochem J, 2000 - PubMed
  11. Heineke J, Molkentin JD; ''Regulation of cardiac hypertrophy by intracellular signalling pathways.; ''Nat Rev Mol Cell Biol, 2006 - PubMed
  12. Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR; ''Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells.; ''J Biol Chem, 1998 - PubMed
  13. Olson EN, Molkentin JD; ''Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype?; ''Circ Res, 1999 - PubMed
  14. Wang J, Xu R, Lin F, Zhang S, Zhang G, Hu S, Zheng Z; ''MicroRNA: novel regulators involved in the remodeling and reverse remodeling of the heart.; ''Cardiology, 2009 - PubMed
  15. Wollert KC, Chien KR; ''Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development.; ''J Mol Med, 1997 - PubMed
  16. Haghikia A, Stapel B, Hoch M, Hilfiker-Kleiner D; ''STAT3 and cardiac remodeling.; ''Heart Fail Rev, 2010 - PubMed
  17. Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, Hewett TE, Jones SP, Lefer DJ, Peng CF, Kitsis RN, Molkentin JD; ''The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.; ''EMBO J, 2000 - PubMed

Categories


History

View all
CompareRevisionActionTimeUserComment
41377view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
37650view09:39, 16 June 2010MLevelsEdited Line
37649view08:00, 16 June 2010MLevelsID
37634view14:40, 14 June 2010MLevelsMicroRNA IDs
37633view14:38, 14 June 2010MLevelsMicroRNA IDs
37632view14:33, 14 June 2010MLevelsIDs of microRNAs converted to mouse
37629view14:26, 14 June 2010MLevelsPeriodical save, work in progress
37628view14:16, 14 June 2010MLevelsPeriodical save, work in progress
37625view14:05, 14 June 2010MLevelsPeriodical save, work in progress
37623view13:55, 14 June 2010MLevelsPeriodical save, work in progress
37613view11:26, 14 June 2010MLevelsSpecify description
37612view11:24, 14 June 2010MLevelsPeriodical save, work in progress
37609view10:54, 14 June 2010MLevelsModified description
37608view10:53, 14 June 2010MLevelsChanged Lines, corrected IDs
37607view10:45, 14 June 2010MLevelsPeriodical save, work in progress
37606view10:34, 14 June 2010MLevelsPeriodical save, work in progress
37605view10:13, 14 June 2010MLevelsModified description
37568view18:09, 11 June 2010MaintBotNew pathway

External references

View all 122...

Name Type Database reference
Pik3r1GeneProduct18708 (Entrez Gene)
mmu-mir-15bRnaMI0000140 (miRBase)
Mapk8GeneProduct26419 (Entrez Gene)
hsa-let-7bRnaENSG00000207875 (Ensembl Human)
Hdac4GeneProduct208727 (Entrez Gene)
Lrp6GeneProduct16974 (Entrez Gene)
Nfatc4GeneProduct73181 (Entrez Gene)
LifGeneProduct16878 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
hsa-mir-23aRnaENSG00000207980 (Ensembl Human)
Edn1GeneProduct13614 (Entrez Gene)
mmu-mir-195-1RnaMI0000237 (miRBase)
Ppp3caGeneProduct19055 (Entrez Gene)
Il6stGeneProduct16195 (Entrez Gene)
IP3MetaboliteHMDB01498 (HMDB)
Rock1GeneProduct19877 (Entrez Gene)
Camk2dGeneProduct108058 (Entrez Gene)
hsa-mir-130bRnaENSG00000207751 (Ensembl Human)
Myef2GeneProduct17876 (Entrez Gene)
mmu-mir-30eRnaMI0000259 (miRBase)
DAGMetaboliteHMDB07009 (HMDB)
hsa-mir-185RnaENSG00000208023 (Ensembl Human)
CalmodulinProtein
hsa-mir-30eRnaENSG00000198974 (Ensembl Human)
CalciumMetaboliteHMDB00464 (HMDB)
Dvl1GeneProduct13542 (Entrez Gene)
Ppp3cbGeneProduct19056 (Entrez Gene)
Eif2b5GeneProduct224045 (Entrez Gene)
AgtGeneProduct11606 (Entrez Gene)
Plcb2GeneProduct18796 (Entrez Gene)
Mapk14GeneProduct26416 (Entrez Gene)
Pik3r3GeneProduct18710 (Entrez Gene)
PrkcbGeneProduct18751 (Entrez Gene)
MylkGeneProduct107589 (Entrez Gene)
Pdpk1GeneProduct18607 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)
NppaGeneProduct230899 (Entrez Gene)
hsa-mir-133a-2RnaENSG00000207764 (Ensembl Human)
NppbGeneProduct18158 (Entrez Gene)
mmu-mir-133bRnaMI0000821 (miRBase)
Cyclic GMPMetaboliteHMDB01314 (HMDB)
hsa-mir-199a-1RnaENSG00000207752 (Ensembl Human)
Prkg1GeneProduct19091 (Entrez Gene)
hsa-mir-125b-1RnaENSG00000207971 (Ensembl Human)
Mapk4GeneProduct225724 (Entrez Gene)
mmu-mir-103-2RnaMI0000588 (miRBase)
Mapk3GeneProduct26417 (Entrez Gene)
hsa-mir-195RnaENSG00000207929 (Ensembl Human)
Map2k4GeneProduct26398 (Entrez Gene)
mmu-mir-21RnaMI0000569 (miRBase)
Fgf2GeneProduct14173 (Entrez Gene)
mmu-mir-125b-1RnaMI0000725 (miRBase)
Igf1GeneProduct16000 (Entrez Gene)
Fzd2GeneProduct57265 (Entrez Gene)
EgfGeneProduct13645 (Entrez Gene)
Wnt5aGeneProduct22418 (Entrez Gene)
Nrg1GeneProduct211323 (Entrez Gene)
Fgfr2GeneProduct14183 (Entrez Gene)
Raf1GeneProduct110157 (Entrez Gene)
hsa-mir-208aRnaMI0000251 (miRBase)
Map2k1GeneProduct26395 (Entrez Gene)
Pik3cdGeneProduct18707 (Entrez Gene)
sPla2-IIAGeneProduct18780 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
Map2k5GeneProduct23938 (Entrez Gene)
RhoaGeneProduct11848 (Entrez Gene)
Mapk7GeneProduct23939 (Entrez Gene)
Rock2GeneProduct19878 (Entrez Gene)
Map2k3GeneProduct26397 (Entrez Gene)
Mylk3GeneProduct213435 (Entrez Gene)
Tgfb1GeneProduct21803 (Entrez Gene)
Ctf1GeneProduct13019 (Entrez Gene)
Map3k7ip1GeneProduct66513 (Entrez Gene)
CishGeneProduct12700 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
hsa-mir-133bRnaENSG00000199080 (Ensembl Human)
MtorGeneProduct56717 (Entrez Gene)
hsa-mir-133a-1RnaENSG00000207786 (Ensembl Human)
Gsk3bGeneProduct56637 (Entrez Gene)
mmu-let-7bRnaMI0000558 (miRBase)
TnfGeneProduct21926 (Entrez Gene)
mmu-mir-27bRnaMI0000142 (miRBase)
Map3k14GeneProduct53859 (Entrez Gene)
mmu-mir-185RnaMI0000227 (miRBase)
IkbkeGeneProduct56489 (Entrez Gene)
hsa-mir-199a-2RnaENSG00000208024 (Ensembl Human)
Nfkb1GeneProduct18033 (Entrez Gene)
hsa-mir-27bRnaENSG00000207864 (Ensembl Human)
Cdk9GeneProduct107951 (Entrez Gene)
hsa-mir-125b-2RnaENSG00000207863 (Ensembl Human)
Hdac5GeneProduct15184 (Entrez Gene)
mmu-mir-103-1RnaMI0000587 (miRBase)
Hdac7GeneProduct56233 (Entrez Gene)
mmu-mir-23aRnaMI0000571 (miRBase)
Hdac9GeneProduct79221 (Entrez Gene)
mmu-mir-195RnaMI0000237 (miRBase)
Akt2GeneProduct11652 (Entrez Gene)
hsa-mir-15bRnaENSG00000207779 (Ensembl Human)
Cdk7GeneProduct12572 (Entrez Gene)
hsa-mir-21RnaENSG00000199004 (Ensembl Human)
Mapk1GeneProduct26413 (Entrez Gene)
mmu-mir-208aRnaMI0000555 (miRBase)
Map2k6GeneProduct26399 (Entrez Gene)
mmu-mir-140RnaMI0000165 (miRBase)
Map2k7GeneProduct26400 (Entrez Gene)
mmu-mir-125b-2RnaMI0000152 (miRBase)
Map2k2GeneProduct26396 (Entrez Gene)
Fzd1GeneProduct14362 (Entrez Gene)
IkbkgGeneProduct16151 (Entrez Gene)
Lrp5GeneProduct16973 (Entrez Gene)
IkbkbGeneProduct16150 (Entrez Gene)
Wnt3aGeneProduct22416 (Entrez Gene)
ChukGeneProduct12675 (Entrez Gene)
Gata4GeneProduct14463 (Entrez Gene)
Rcan1GeneProduct54720 (Entrez Gene)
Ctnnb1GeneProduct12387 (Entrez Gene)
Pik3caGeneProduct18706 (Entrez Gene)
Igf1rGeneProduct16001 (Entrez Gene)
Pik3cbGeneProduct74769 (Entrez Gene)
hsa-mir-140RnaENSG00000208017 (Ensembl Human)
Pik3cgGeneProduct30955 (Entrez Gene)
hsa-mir-214RnaMI0000290 (miRBase)
Retrieved from "http://wikipathways.org/index.php/Pathway:WP1560"
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