MicroRNAs in cardiomyocyte hypertrophy (Homo sapiens)

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Contents



Curation Tags

Description

This pathway shows the role of microRNAs in the process of cardiac hypertrophy.

MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in pink. MicroRNAs are shown as purple rounded rectangles.

It is not sure which WNT and frizzled proteins influence cardiac hypertrophy. Though there are strong indications that WNT3A, WNT5A, frizzled1 and frizzled2 play a role in cardiac hypertrophy. Thus these have been added to the pathway instead of all the WNT and frizzled proteins. Experiments which will shed light on this are still being done.

Ontology Tags

 

Bibliography

View all 17 references
  1. Lim HW, Molkentin JD; ''Calcineurin and human heart failure.; ''Nat Med, 1999 - PubMed
  2. Haghikia A, Stapel B, Hoch M, Hilfiker-Kleiner D; ''STAT3 and cardiac remodeling.; ''Heart Fail Rev, 2010 - PubMed
  3. Clerk A, Sugden PH; ''Small guanine nucleotide-binding proteins and myocardial hypertrophy.; ''Circ Res, 2000 - PubMed
  4. Carè A, Catalucci D, Felicetti F, Bonci D, Addario A, Gallo P, Bang ML, Segnalini P, Gu Y, Dalton ND, Elia L, Latronico MV, Høydal M, Autore C, Russo MA, Dorn GW 2nd, Ellingsen O, Ruiz-Lozano P, Peterson KL, Croce CM, Peschle C, Condorelli G; ''MicroRNA-133 controls cardiac hypertrophy.; ''Nat Med, 2007 - PubMed
  5. Vanhaesebroeck B, Alessi DR; ''The PI3K-PDK1 connection: more than just a road to PKB.; ''Biochem J, 2000 - PubMed
  6. Wollert KC, Chien KR; ''Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development.; ''J Mol Med, 1997 - PubMed
  7. Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, Hewett TE, Jones SP, Lefer DJ, Peng CF, Kitsis RN, Molkentin JD; ''The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.; ''EMBO J, 2000 - PubMed
  8. Wang J, Xu R, Lin F, Zhang S, Zhang G, Hu S, Zheng Z; ''MicroRNA: novel regulators involved in the remodeling and reverse remodeling of the heart.; ''Cardiology, 2009 - PubMed
  9. Molkentin JD; ''Calcineurin and beyond: cardiac hypertrophic signaling.; ''Circ Res, 2000 - PubMed
  10. Heineke J, Molkentin JD; ''Regulation of cardiac hypertrophy by intracellular signalling pathways.; ''Nat Rev Mol Cell Biol, 2006 - PubMed
  11. Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR; ''Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells.; ''J Biol Chem, 1998 - PubMed
  12. Jalili T, Takeishi Y, Walsh RA; ''Signal transduction during cardiac hypertrophy: the role of G alpha q, PLC beta I, and PKC.; ''Cardiovasc Res, 1999 - PubMed
  13. Takeishi Y, Ping P, Bolli R, Kirkpatrick DL, Hoit BD, Walsh RA; ''Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy.; ''Circ Res, 2000 - PubMed
  14. Blankesteijn WM, van de Schans VA, ter Horst P, Smits JF; ''The Wnt/frizzled/GSK-3 beta pathway: a novel therapeutic target for cardiac hypertrophy.; ''Trends Pharmacol Sci, 2008 - PubMed
  15. Wollert KC, Taga T, Saito M, Narazaki M, Kishimoto T, Glembotski CC, Vernallis AB, Heath JK, Pennica D, Wood WI, Chien KR; ''Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways.; ''J Biol Chem, 1996 - PubMed
  16. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN; ''A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.; ''Cell, 1998 - PubMed
  17. Olson EN, Molkentin JD; ''Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype?; ''Circ Res, 1999 - PubMed

Categories


History

View all
CompareRevisionActionTimeUserComment
59101view22:12, 21 February 2013MaintBotUpdated Ensembl data source
45381view21:47, 7 October 2011KhanspersOntology Term : 'heart disease' added !
44907view10:26, 6 October 2011MartijnVanIerselOntology Term : 'miRNA pathway' added !
41050view23:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
37611view11:02, 14 June 2010MLevelsModified description
37610view10:59, 14 June 2010MLevelsChanged Lines
37553view12:58, 10 June 2010MLevelsMoved some microRNAs
37552view12:56, 10 June 2010MLevelsAdded some microRNAs
37551view12:46, 10 June 2010MLevelsPeriodical save, work in progress
37541view10:54, 10 June 2010MLevelsDeleted non-canonical wnt
37534view13:14, 9 June 2010MLevelsNon-Canonical Wnt Pathway
37438view09:20, 4 June 2010MLevelsMicroRNAs added
37407view12:04, 1 June 2010MLevelsMinor Changes
37406view11:57, 1 June 2010MLevelsPeriodical save, work in progress
37399view11:28, 1 June 2010MLevelsPeriodical save, work in progress
37395view10:45, 1 June 2010MLevelsAdded WNT pathway
37393view10:38, 1 June 2010MLevelsModified description
37392view10:12, 1 June 2010MLevelsPeriodical save, work in progress
37391view10:01, 1 June 2010MLevelsPeriodical save, work in progress
37388view09:51, 1 June 2010MLevelsPeriodical save, work in progress
37387view09:12, 1 June 2010MLevelsModified description
37345view08:49, 28 May 2010MLevelsPeriodical save, work in progress
37344view08:35, 28 May 2010MLevelsPeriodical save, work in progress
37343view08:22, 28 May 2010MLevelsPeriodical save, work in progress
37342view08:12, 28 May 2010MLevelsPeriodical save, work in progress
37341view08:02, 28 May 2010MLevelsPeriodical save, work in progress
37340view07:51, 28 May 2010MLevelsPeriodical save, work in progress
37336view14:16, 27 May 2010MLevelsMicroRNAs added
37335view14:06, 27 May 2010MLevelsPeriodical save, work in progress
37334view13:56, 27 May 2010MLevelsPeriodical save, work in progress
37333view13:46, 27 May 2010MLevelsPeriodical save, work in progress
37332view13:34, 27 May 2010MLevelsPeriodical save, work in progress
37331view13:24, 27 May 2010MLevelsPeriodical save, work in progress
37330view13:13, 27 May 2010MLevelsPeriodical save, work in progress
37329view13:02, 27 May 2010MLevelsPeriodical save, work in progress
37328view12:32, 27 May 2010MLevelsPeriodical save, work in progress
37327view12:21, 27 May 2010MLevelsPeriodical save, work in progress
37326view12:11, 27 May 2010MLevelsPeriodical save, work in progress
37295view08:42, 25 May 2010MLevelsColored Line
37294view08:41, 25 May 2010MLevelsID
37293view08:36, 25 May 2010MLevelsNew pathway

External references

View all 106...

Name Type Database reference
PIK3CGGeneProduct5294 (Entrez Gene)
hsa-mir-208aRnaENSG00000199157 (Ensembl Human)
JNKGeneProduct5599 (Entrez Gene)
hsa-mir-133a-2RnaENSG00000207764 (Ensembl Human)
HDAC 4GeneProduct9759 (Entrez Gene)
MEK7GeneProduct5609 (Entrez Gene)
NFAT3GeneProduct4776 (Entrez Gene)
MLCK1GeneProduct4638 (Entrez Gene)
Rac1GeneProduct5879 (Entrez Gene)
hsa-mir-23aRnaENSG00000207980 (Ensembl Human)
ET-1GeneProduct1906 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)
CalNAGeneProduct5530 (Entrez Gene)
IKKaGeneProduct1147 (Entrez Gene)
IP3MetaboliteHMDB01498 (HMDB)
PIK3R3GeneProduct8503 (Entrez Gene)
CamKGeneProduct817 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
MEF-2GeneProduct50804 (Entrez Gene)
hsa-mir-30eRnaENSG00000198974 (Ensembl Human)
DAGMetaboliteHMDB07009 (HMDB)
hsa-mir-103-2-asRnaENSG00000199024 (Ensembl Human)
CalmodulinProtein801 (Entrez Gene)
FZD2GeneProduct2535 (Entrez Gene)
CalciumMetaboliteHMDB00464 (HMDB)
PLCGeneProduct5330 (Entrez Gene)
CalNBGeneProduct5532 (Entrez Gene)
IKKgGeneProduct8517 (Entrez Gene)
Ang IIGeneProduct183 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
p38GeneProduct1432 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PKCGeneProduct5579 (Entrez Gene)
ROCK1GeneProduct6093 (Entrez Gene)
PDKGeneProduct5170 (Entrez Gene)
LIFGeneProduct3976 (Entrez Gene)
ANPGeneProduct4878 (Entrez Gene)
hsa-mir-130bRnaENSG00000207751 (Ensembl Human)
BNPGeneProduct4879 (Entrez Gene)
hsa-let-7bRnaENSG00000207875 (Ensembl Human)
Cyclic GMPMetaboliteHMDB01314 (HMDB)
hsa-mir-199a-1RnaENSG00000207752 (Ensembl Human)
PKG IGeneProduct5592 (Entrez Gene)
hsa-mir-125b-2RnaENSG00000207863 (Ensembl Human)
MAPKKKKGeneProduct5596 (Entrez Gene)
hsa-mir-195RnaENSG00000207929 (Ensembl Human)
MAPKKKGeneProduct5595 (Entrez Gene)
Dvl1GeneProduct1855 (Entrez Gene)
MEK4GeneProduct6416 (Entrez Gene)
LRP6GeneProduct4040 (Entrez Gene)
FGFGeneProduct2247 (Entrez Gene)
eIF2BεGeneProduct8893 (Entrez Gene)
IGFIGeneProduct3479 (Entrez Gene)
MEK6GeneProduct5608 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
MEK2GeneProduct5605 (Entrez Gene)
NeuregulinGeneProduct3084 (Entrez Gene)
IKKbGeneProduct3551 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RCAN1GeneProduct1827 (Entrez Gene)
MEK1GeneProduct5604 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
ERK1GeneProduct5595 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PLA2GeneProduct5320 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
MEK5GeneProduct5607 (Entrez Gene)
RhoAGeneProduct387 (Entrez Gene)
ERK5GeneProduct5598 (Entrez Gene)
ROCK2GeneProduct9475 (Entrez Gene)
MEK3GeneProduct5606 (Entrez Gene)
MLCK3GeneProduct91807 (Entrez Gene)
TGFβGeneProduct7040 (Entrez Gene)
CT-1GeneProduct1489 (Entrez Gene)
TAK1GeneProduct10454 (Entrez Gene)
SOCSGeneProduct1154 (Entrez Gene)
PDK1GeneProduct5170 (Entrez Gene)
hsa-mir-133bRnaENSG00000199080 (Ensembl Human)
AKT1GeneProduct207 (Entrez Gene)
hsa-mir-133a-1RnaENSG00000207786 (Ensembl Human)
mTORGeneProduct2475 (Entrez Gene)
hsa-mir-27bRnaENSG00000207864 (Ensembl Human)
GSK3βGeneProduct2932 (Entrez Gene)
hsa-mir-185RnaENSG00000208023 (Ensembl Human)
TNFαGeneProduct7124 (Entrez Gene)
hsa-mir-199a-2RnaENSG00000208024 (Ensembl Human)
NIKGeneProduct9020 (Entrez Gene)
hsa-mir-125b-1RnaENSG00000207971 (Ensembl Human)
IκBGeneProduct9641 (Entrez Gene)
hsa-mir-103-1-asRnaENSG00000199035 (Ensembl Human)
NFκBGeneProduct4790 (Entrez Gene)
hsa-mir-15bRnaENSG00000207779 (Ensembl Human)
CDK 9GeneProduct1025 (Entrez Gene)
hsa-mir-21RnaENSG00000199004 (Ensembl Human)
HDAC 5GeneProduct10014 (Entrez Gene)
hsa-mir-140RnaENSG00000208017 (Ensembl Human)
HDAC 7GeneProduct51564 (Entrez Gene)
FZD1GeneProduct8321 (Entrez Gene)
HDAC 9GeneProduct9734 (Entrez Gene)
LRP5GeneProduct4041 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
CDK 7GeneProduct1022 (Entrez Gene)
GATA4GeneProduct2626 (Entrez Gene)
ERK2GeneProduct5594 (Entrez Gene)
β-cateninGeneProduct1499 (Entrez Gene)
Retrieved from "http://wikipathways.org/index.php/Pathway:WP1544"
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