Physiological and Pathological Hypertrophy of the Heart (Homo sapiens)

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Contents 1 Curation Tags 2 Description 3 Ontology Tags 4 Bibliography 5 Categories 6 History 7 External references

Curation Tags

Description

Ontology Tags

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Bibliography

1. Molkentin JD; ''Calcineurin and beyond: cardiac hypertrophic signaling.; ''Circ Res, 2000 - PubMed
2. MacLellan WR; ''Advances in the molecular mechanisms of heart failure.; ''Curr Opin Cardiol, 2000 - PubMed
3. Jalili T, Takeishi Y, Walsh RA; ''Signal transduction during cardiac hypertrophy: the role of G alpha q, PLC beta I, and PKC.; ''Cardiovasc Res, 1999 - PubMed
4. Wollert KC, Taga T, Saito M, Narazaki M, Kishimoto T, Glembotski CC, Vernallis AB, Heath JK, Pennica D, Wood WI, Chien KR; ''Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways.; ''J Biol Chem, 1996 - PubMed
5. Wang Y; ''Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathological pathways utilizing a transgenic approach.; ''Curr Opin Pharmacol, 2001 - PubMed
6. Olson EN, Molkentin JD; ''Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype?; ''Circ Res, 1999 - PubMed
7. Takeishi Y, Ping P, Bolli R, Kirkpatrick DL, Hoit BD, Walsh RA; ''Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy.; ''Circ Res, 2000 - PubMed
8. Clerk A, Sugden PH; ''Small guanine nucleotide-binding proteins and myocardial hypertrophy.; ''Circ Res, 2000 - PubMed
9. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN; ''A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.; ''Cell, 1998 - PubMed
10. Lim HW, Molkentin JD; ''Calcineurin and human heart failure.; ''Nat Med, 1999 - PubMed
11. Hunter JJ, Chien KR; ''Signaling pathways for cardiac hypertrophy and failure.; ''N Engl J Med, 1999 - PubMed
12. Wollert KC, Chien KR; ''Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development.; ''J Mol Med, 1997 - PubMed
13. Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR; ''Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells.; ''J Biol Chem, 1998 - PubMed
14. Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, Hewett TE, Jones SP, Lefer DJ, Peng CF, Kitsis RN, Molkentin JD; ''The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.; ''EMBO J, 2000 - PubMed
15. Heineke J, Molkentin JD; ''Regulation of cardiac hypertrophy by intracellular signalling pathways.; ''Nat Rev Mol Cell Biol, 2006 - PubMed

Categories

History

External references

Name	Type	Database reference
Calmodulin	Protein	801 (Entrez Gene)
LIFR	GeneProduct	3977 (Entrez Gene)
GATA-4	GeneProduct	2626 (Entrez Gene)
gp130	GeneProduct	3572 (Entrez Gene)
p38	GeneProduct	1432 (Entrez Gene)
STAT3	GeneProduct	6774 (Entrez Gene)
CTF1	GeneProduct	1489 (Entrez Gene)
erk	GeneProduct	5594 (Entrez Gene)
CalNA	GeneProduct	5530 (Entrez Gene)
p38b	GeneProduct	5600 (Entrez Gene)
FOS	GeneProduct	2353 (Entrez Gene)
PKCE	GeneProduct	5581 (Entrez Gene)
CalNB	GeneProduct	5532 (Entrez Gene)
Ang II	GeneProduct	183 (Entrez Gene)
p38a	GeneProduct	1432 (Entrez Gene)
ET-1	GeneProduct	1906 (Entrez Gene)
Calcium	Metabolite	HMDB00464 (HMDB)
Rac1	GeneProduct	5879 (Entrez Gene)
CamK	GeneProduct	817 (Entrez Gene)
MKK3	GeneProduct	5606 (Entrez Gene)
C-JUN	GeneProduct	3725 (Entrez Gene)
JNK	GeneProduct	5599 (Entrez Gene)
NFAT3	GeneProduct	4776 (Entrez Gene)
RhoA	GeneProduct	387 (Entrez Gene)
MEF-2	GeneProduct	50804 (Entrez Gene)
PKCb	GeneProduct	5579 (Entrez Gene)
PE	Metabolite	HMDB02182 (HMDB)