TOR signaling (Homo sapiens)
TOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central regulator that consists in two different complexes: a rapamycin-sensitive complex (mTORC1) consisting of mTOR, Raptor and GbetaL that regulates mRNA translation, ribosome biogenesis and autophagy and a second rapamycin-insensitive complex (mTORC2) consisting of mTOR, Rictor GbetaL, Sin1 and Protor 1/2 that regulates survival and a cytoskeletal response. TOR signaling is highly integrated in other signaling pathways that respond to external conditions, such as the insulin-signaling cascade and AMPK signaling.
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|RAC1||GeneProduct||ENSG00000136238 (Ensembl Human)|
|EIF4EBP1||GeneProduct||ENSG00000187840 (Ensembl Human)|
|PRKCA||GeneProduct||ENSG00000154229 (Ensembl Human)|
|MTOR||GeneProduct||ENSG00000198793 (Ensembl Human)|
|RRAGC||GeneProduct||ENSG00000116954 (Ensembl Human)|