TOR signaling (Homo sapiens)

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Description

TOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central regulator that consists in two different complexes: a rapamycin-sensitive complex (mTORC1) consisting of mTOR, Raptor and GbetaL that regulates mRNA translation, ribosome biogenesis and autophagy and a second rapamycin-insensitive complex (mTORC2) consisting of mTOR, Rictor GbetaL, Sin1 and Protor 1/2 that regulates survival and a cytoskeletal response. TOR signaling is highly integrated in other signaling pathways that respond to external conditions, such as the insulin-signaling cascade and AMPK signaling

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Bibliography

View all 5 references
  1. Yang Q, Guan KL; ''Expanding mTOR signaling.; ''Cell Res, 2007 - PubMed
  2. Corradetti MN, Guan KL; ''Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?; ''Oncogene, 2006 - PubMed
  3. Wullschleger S, Loewith R, Hall MN; ''TOR signaling in growth and metabolism.; ''Cell, 2006 - PubMed
  4. Inoki K, Guan KL; ''Complexity of the TOR signaling network.; ''Trends Cell Biol, 2006 - PubMed
  5. Sancak Y, Sabatini DM; ''Rag proteins regulate amino-acid-induced mTORC1 signalling.; ''Biochem Soc Trans, 2009 - PubMed

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History

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CompareRevisionActionTimeUserComment
61698view23:24, 16 April 2013MaintBotremoved data source without identifer
60230view20:12, 14 March 2013EgonwReplaced PubChem-substance with PubChem-compound.
60227view20:10, 14 March 2013EgonwAnnotated 'amino acid' with an ChEBI entry.
59195view19:07, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
48241view06:07, 17 May 2012MaintBotUpdating PubChem xrefs
45081view20:42, 6 October 2011KhanspersOntology Term : 'insulin signaling pathway' added !
45080view20:41, 6 October 2011KhanspersOntology Term : 'AMPK signaling pathway' added !
45078view20:40, 6 October 2011KhanspersOntology Term : 'mTOR signaling pathway' added !
41181view23:42, 1 March 2011MaintBotRemoved redundant pathway information and comments
38698view19:08, 23 September 2010AlexanderPicopathway nodes
38691view18:26, 23 September 2010AlexanderPicoadded pathway nodes; altered labels for conditions and phenotypes
36157view16:59, 3 March 2010Pieter GiesbertzSpecify description
36156view15:53, 3 March 2010Pieter GiesbertzModified categories
36155view15:48, 3 March 2010Pieter GiesbertzSpecify description
36140view12:31, 3 March 2010Pieter GiesbertzSpecify description
36139view12:15, 3 March 2010Pieter GiesbertzPeriodical save, work in progress
36138view11:44, 3 March 2010Pieter GiesbertzModified description
36137view11:41, 3 March 2010Pieter GiesbertzPeriodical save, work in progress
36095view10:09, 3 March 2010Pieter GiesbertzAdded literature
36042view09:17, 3 March 2010Pieter GiesbertzSpecify description
36041view09:06, 3 March 2010Pieter GiesbertzPeriodical save, work in progress
36040view08:35, 3 March 2010Pieter GiesbertzPeriodical save, work in progress
36039view16:22, 2 March 2010Pieter GiesbertzSpecify description
36038view16:19, 2 March 2010Pieter GiesbertzSpecify description
36037view16:17, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36035view16:06, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36032view15:40, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36031view15:17, 2 March 2010Pieter GiesbertzSpecify description
36030view15:10, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36029view15:00, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36026view12:55, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36025view12:39, 2 March 2010Pieter GiesbertzSpecify description
36024view12:34, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36023view12:14, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36022view12:04, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36021view12:00, 2 March 2010Pieter GiesbertzSpecify description
36020view11:54, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36019view11:47, 2 March 2010Pieter GiesbertzSpecify description
36012view16:07, 1 March 2010Pieter GiesbertzPeriodical save, work in progress
36011view15:40, 1 March 2010Pieter GiesbertzPeriodical save, work in progress
36009view11:48, 1 March 2010Pieter GiesbertzSpecify description
36008view10:12, 1 March 2010Pieter GiesbertzPeriodical save, work in progress
36006view10:01, 1 March 2010Pieter GiesbertzSpecify description
36005view09:52, 1 March 2010Pieter GiesbertzPeriodical save, work in progress
36004view09:38, 1 March 2010Pieter Giesbertzbeginning
36003view09:32, 1 March 2010Pieter GiesbertzNew pathway

External references

View all 35...

Name Type Database reference
RAC1GeneProductENSG00000136238 (Ensembl Human)
EIF4EBP1GeneProductENSG00000187840 (Ensembl Human)
PRKCAGeneProductENSG00000154229 (Ensembl Human)
MTORGeneProductENSG00000198793 (Ensembl Human)
RRAGCGeneProductENSG00000116954 (Ensembl Human)
RICTORGeneProductENSG00000164327 (Ensembl Human)
PRKAB2GeneProductENSG00000131791 (Ensembl Human)
MLST8GeneProductENSG00000167965 (Ensembl Human)
RapamycinMetabolite7847818 (PubChem)
TSC1GeneProductENSG00000165699 (Ensembl Human)
PRR5LGeneProductENSG00000135362 (Ensembl Human)
RHEBGeneProductENSG00000106615 (Ensembl Human)
PRKAA2GeneProductENSG00000162409 (Ensembl Human)
RPTORGeneProductENSG00000141564 (Ensembl Human)
PRKAG2GeneProductENSG00000106617 (Ensembl Human)
FKBP1AGeneProductENSG00000088832 (Ensembl Human)
DDIT4GeneProductENSG00000168209 (Ensembl Human)
RPS6KB1GeneProductENSG00000108443 (Ensembl Human)
RRAGBGeneProductENSG00000083750 (Ensembl Human)
AKT1S1GeneProductENSG00000204673 (Ensembl Human)
RRAGDGeneProductENSG00000025039 (Ensembl Human)
MAPKAP1GeneProductENSG00000119487 (Ensembl Human)
PRR5GeneProductENSG00000186654 (Ensembl Human)
TSC2GeneProductENSG00000103197 (Ensembl Human)
PRKAB1GeneProductENSG00000111725 (Ensembl Human)
AKT1GeneProductENSG00000142208 (Ensembl Human)
PRKAA1GeneProductENSG00000132356 (Ensembl Human)
ULK1GeneProductENSG00000177169 (Ensembl Human)
PRKAG1GeneProductENSG00000181929 (Ensembl Human)
ULK2GeneProductENSG00000083290 (Ensembl Human)
PRKAG3GeneProductENSG00000115592 (Ensembl Human)
ULK3GeneProductENSG00000140474 (Ensembl Human)
CDC42GeneProductENSG00000070831 (Ensembl Human)
RRAGAGeneProductENSG00000155876 (Ensembl Human)
DDIT4LGeneProductENSG00000145358 (Ensembl Human)
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