Signaling pathways are rarely brought about by isolated reactions but rather by a cascade of events that can involve multiple subcellular compartments. Often, signaling pathways are studied with a focus on the roles of isolated members which makes it difficult to generate a comprehensive view of the pathway as a whole. There are other efforts in the public domain, which are generally not very detailed. In order to address these issues, we initiated the NetPath project.
In case you are using our data, please cite the following references:
Kandasamy, K. and Mohan, S. S. et al. (2010) NetPath: A public resource of curated signal transduction pathways. Genome Biology. PubMed
Raju, R. et al. (2011) Netslim: High-confidence curated signaling maps. Database. PubMed
For the following pathways, please cite
Raju, R. et al. (2011). A comprehensive manually curated reaction map of RANKL/RANK signaling pathway. Database. PubMed
Nanjappa, V. et al. (2011). A comprehensive curated reaction map of leptin signaling pathway. Journal of Proteomics and Bioinformatics. PubMed
Telikicherla, D. et al. (2011). A comprehensive curated resource for Follicle Stimulating Hormone signaling. BMC Research Notes. PubMed
Goel, R. et al. (2011). A signaling network of thyroid-stimulating hormone. Journal of Proteomics and Bioinformatics. PubMed
Bhattacharjee, M. et al. (2012). A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway. Journal of Signal Transduction. In press.