Cholesterol Biosynthesis (Gallus gallus)

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Description

Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP197(r21093) with a 82% conversion rate.

Ontology Tags

 

Bibliography

View all 7 references
  1. Ohashi M, Mizushima N, Kabeya Y, Yoshimori T; ''Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets.; ''J Biol Chem, 2003 - PubMed
  2. Sagami H, Korenaga T, Ogura K; ''Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate.; ''J Biochem, 1993 - PubMed
  3. Gaylor JL; ''Membrane-bound enzymes of cholesterol synthesis from lanosterol.; ''Biochem Biophys Res Commun, 2002 - PubMed
  4. Liu XY, Dangel AW, Kelley RI, Zhao W, Denny P, Botcherby M, Cattanach B, Peters J, Hunsicker PR, Mallon AM, Strivens MA, Bate R, Miller W, Rhodes M, Brown SD, Herman GE; ''The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase.; ''Nat Genet, 1999 - PubMed
  5. Li L, Kaplan J; ''Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue.; ''J Biol Chem, 1996 - PubMed
  6. Bard M, Bruner DA, Pierson CA, Lees ND, Biermann B, Frye L, Koegel C, Barbuch R; ''Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase.; ''Proc Natl Acad Sci U S A, 1996 - PubMed
  7. Noshiro M, Aoyama Y, Kawamoto T, Gotoh O, Horiuchi T, Yoshida Y; ''Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: I. Structural analyses of the gene and multiple sizes of mRNA.; ''J Biochem, 1997 - PubMed

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History

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CompareRevisionActionTimeUserComment
41001view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
35154view14:24, 11 February 2010ThomasModified description
35153view14:23, 11 February 2010Thomasmoved literature from genmapp comments to bibliography
33922view18:07, 9 December 2009MaintBotAutomatic update of empty xrefs
33503view15:14, 30 November 2009MaintBotRemoved group label
30402view21:10, 29 July 2009MaintBotNew pathway

External references

View all 30...

Name Type Database reference
FDPSGeneProduct425061 (Entrez Gene)
Mevalonic acid 5-pyrophosphateMetabolite1492-08-6 (CAS)
IDI1GeneProduct420459 (Entrez Gene)
CholesterolMetabolite57-88-5 (CAS)
HMGCS1GeneProduct396379 (Entrez Gene)
7-DehydrocholesterolMetabolite434-16-2 (CAS)
HMGCRGeneProduct395145 (Entrez Gene)
SqualeneMetabolite111-02-4 (CAS)
MVKGeneProduct768555 (Entrez Gene)
Mevalonic acidMetabolite150-97-0 (CAS)
MVDGeneProduct425359 (Entrez Gene)
Geranyl-PPMetabolite6699-20-3 (CAS)
FDFT1GeneProduct422038 (Entrez Gene)
(S)-2,3-EpoxysqualeneMetabolite9029-62-3 (CAS)
DHCR7GeneProduct422982 (Entrez Gene)
Acetyl-CoAMetabolite (CAS)
SC5DLGeneProduct
LathosterolMetabolite80-99-9 (CAS)
LSSGeneProduct424037 (Entrez Gene)
HMG-CoAMetabolite (CAS)
SQLEGeneProduct420335 (Entrez Gene)
Mevalonic acid-5PMetabolite73566-35-5 (CAS)
PMVKGeneProduct
farnesyl pyrophosphateMetabolite13058-04-3 (CAS)
NSDHLGeneProduct422302 (Entrez Gene)
DimethylallylpyrophosphateMetabolite358-72-5 (CAS)
CYP51A1GeneProduct420548 (Entrez Gene)
LanosterinMetabolite79-63-0 (CAS)
SC4MOLGeneProduct422423 (Entrez Gene)
isopentenyl pyrophosphateMetabolite358-71-4 (CAS)
Retrieved from "http://wikipathways.org/index.php/Pathway:WP833"
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