Vitamin A and carotenoid metabolism (Homo sapiens)

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Contents



Curation Tags

Description

This pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some additional entities (see Waagmeester et al. 2009).

Ontology Tags

 

Bibliography

View all 17 references
  1. Ruhl CE, Everhart JE; ''Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States.; ''Gastroenterology, 2003 - PubMed
  2. Czeczuga-Semeniuk E, Wolczynski S, Markiewicz W; ''Preliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue.; ''Neoplasma, 2003 - PubMed
  3. Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL; ''Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis.; ''Eur J Pediatr, 1997 - PubMed
  4. Khachik F, Beecher GR, Goli MB, Lusby WR, Smith JC Jr; ''Separation and identification of carotenoids and their oxidation products in the extracts of human plasma.; ''Anal Chem, 1992 - PubMed
  5. Waagmeester A, Pezik P, Coort S, Tourniaire F, Evelo C, Rebholz-Schuhmann D; ''Pathway enrichment based on text mining and its validation on carotenoid and vitamin A metabolism.; ''OMICS, 2009 - PubMed
  6. Hidiroglou M, Williams CJ; ''Interrelationships among liposoluble vitamins in ruminants.; ''Am J Vet Res, 1986 - PubMed
  7. Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, Levy J, Sharoni Y; ''Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells.; ''Nutr Cancer, 1999 - PubMed
  8. Sies H, Stahl W, Sundquist AR; ''Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids.; ''Ann N Y Acad Sci, 1992 - PubMed
  9. Torma H, Rollman O, Binderup L, Michaelsson G; ''Vitamin D analogs affect the uptake and metabolism of retinol by human epidermal keratinocytes in culture.; ''J Investig Dermatol Symp Proc, 1996 - PubMed
  10. Olmedilla B, Granado F, Blanco I, Rojas-Hidalgo E; ''Seasonal and sex-related variations in six serum carotenoids, retinol, and alpha-tocopherol.; ''Am J Clin Nutr, 1994 - PubMed
  11. Johansson S, Melhus H; ''Vitamin A antagonizes calcium response to vitamin D in man.; ''J Bone Miner Res, 2001 - PubMed
  12. VandenLangenberg GM, Brady WE, Nebeling LC, Block G, Forman M, Bowen PE, Stacewicz-Sapuntzakis M, Mares-Perlman JA; ''Influence of using different sources of carotenoid data in epidemiologic studies.; ''J Am Diet Assoc, 1996 - PubMed
  13. Bendich A, Olson JA; ''Biological actions of carotenoids.; ''FASEB J, 1989 - PubMed
  14. Balmer JE, Blomhoff R; ''Gene expression regulation by retinoic acid.; ''J Lipid Res, 2002 - PubMed
  15. Boosalis MG, Snowdon DA, Tully CL, Gross MD; ''Acute phase response and plasma carotenoid concentrations in older women: findings from the nun study.; ''Nutrition, 1996 - PubMed
  16. Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, Beecher GR, Smith JC Jr; ''Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men.; ''Am J Clin Nutr, 1992 - PubMed
  17. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG; ''Carotenoids in the human macula and whole retina.; ''Invest Ophthalmol Vis Sci, 1988 - PubMed

Categories


History

View all
CompareRevisionActionTimeUserComment
59134view22:37, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
52902view09:57, 24 October 2012AnweshaPeriodical save, work in progress
46094view03:31, 15 December 2011AlexanderPicoconverted hugo to ensembl
46090view02:28, 15 December 2011AllanKuchinskyupdated HGNC IDs
45017view18:32, 6 October 2011KhanspersOntology Term : 'metabolic pathway of cofactors and vitamins' added !
41087view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
38841view17:39, 24 September 2010KhanspersChanged nucleus
38356view07:17, 2 September 2010ThomasReverted to version '11:08, 17 May 2010' by Thomas
38355view07:16, 2 September 2010ThomasPeriodical save, work in progress
37110view11:08, 17 May 2010SusanAdd connection
37109view11:07, 17 May 2010SusanAdd Awat2
37108view10:45, 17 May 2010SusanAdd Awat
37107view10:28, 17 May 2010SusanAdd connection
37106view10:21, 17 May 2010EveloCorrected typo in title
37105view10:19, 17 May 2010SusanAdd connections
37103view10:15, 17 May 2010EveloModified title and version date
36978view11:10, 14 May 2010Evelofinishing up
36977view11:07, 14 May 2010Evelofinishing up
36976view10:57, 14 May 2010EveloPeriodical save, work in progress
36975view10:47, 14 May 2010EveloPeriodical save, work in progress
36974view10:35, 14 May 2010EveloMetabolites and connectors
36973view10:32, 14 May 2010EveloPeriodical save, work in progress
36972view10:21, 14 May 2010EveloPeriodical save, work in progress
36971view10:11, 14 May 2010EveloPeriodical save, work in progress
36970view10:01, 14 May 2010EveloPeriodical save, work in progress
36969view09:50, 14 May 2010EveloPeriodical save, work in progress
36968view09:40, 14 May 2010EveloPeriodical save, work in progress
36967view09:30, 14 May 2010EveloPeriodical save, work in progress
36966view09:19, 14 May 2010EveloModified description
36965view18:04, 13 May 2010EveloPeriodical save, work in progress
36964view17:55, 13 May 2010EveloAdded retinol dh
36963view17:53, 13 May 2010EveloPeriodical save, work in progress
36962view17:50, 13 May 2010EveloSafety
36961view17:22, 13 May 2010EveloPeriodical save, work in progress
36959view17:12, 13 May 2010EveloPeriodical save, work in progress
36950view17:00, 13 May 2010EveloMinor edits
36944view11:34, 13 May 2010EveloCorrected many identifiers
36943view11:30, 13 May 2010EveloPeriodical save, work in progress
36942view11:20, 13 May 2010EveloPeriodical save, work in progress
36941view11:09, 13 May 2010EveloCorrected some identifiers
36940view10:51, 13 May 2010EveloBetabarotene as a metabolite
36860view08:41, 12 May 2010EveloPeriodical save, work in progress
33029view16:32, 5 October 2009AndraCorrection in the references
33028view16:28, 5 October 2009AndraNew reference
32745view23:22, 3 September 2009MaintBotModified categories
30274view20:33, 25 July 2009AlexanderPicofixed unsupported characters in Bibliography
30052view22:56, 29 June 2009AndraModified description
30049view22:33, 29 June 2009AndraAdded references
30048view22:22, 29 June 2009AndraPeriodical save, work in progress
30047view22:12, 29 June 2009AndraPeriodical save, work in progress

External references

View all 70...

Name Type Database reference
9-cis-Retinoic acidMetaboliteHMDB02369 (HMDB)
LuteinMetaboliteHMDB03233 (HMDB)
Rdh850700 (Entrez Gene)
Sult2b16820 (Entrez Gene)
RARg5916 (Entrez Gene)
Retinyl esterMetaboliteHMDB03598 (HMDB)
Aldh1a2GeneProduct8854 (Entrez Gene)
Scarb1949 (Entrez Gene)
Npc1l129881 (Entrez Gene)
ViolaxanthinMetaboliteHMDB03101 (HMDB)
RXRa6256 (Entrez Gene)
BetacaroteneMetaboliteHMDB00561 (HMDB)
Rbp7GeneProduct116362 (Entrez Gene)
9-cis-RetinalMetaboliteHMDB06218 (HMDB)
Abcg564240 (Entrez Gene)
4-oxo-Retinoic acidMetaboliteHMDB06285 (HMDB)
Cd36948 (Entrez Gene)
RPE656121 (Entrez Gene)
Rdh10157506 (Entrez Gene)
Alpha-CaroteneMetaboliteHMDB03993 (HMDB)
Rbp2GeneProduct5948 (Entrez Gene)
Beta-CryptoxanthinMetaboliteHMDB02268 (HMDB)
Aldh1a1GeneProduct216 (Entrez Gene)
LycopeneMetaboliteHMDB03000 (HMDB)
Adh4GeneProduct127 (Entrez Gene)
Retinol Vitamin AMetaboliteHMDB00305 (HMDB)
Rdh12145226 (Entrez Gene)
all-trans Retinoic acid Vitamin A acidMetaboliteHMDB01852 (HMDB)
RXRg6258 (Entrez Gene)
11-cis-RetinolMetaboliteHMDB06216 (HMDB)
Lpl4023 (Entrez Gene)
13,14 dehydroretinalMetabolite (HMDB)
Abcg864241 (Entrez Gene)
beta 10' apocorotenalMetabolite (HMDB)
Bcdo2GeneProduct83875 (Entrez Gene)
ARATProtein2.3.1.76 (EC Number)
RXRb6257 (Entrez Gene)
RARb5915 (Entrez Gene)
Adh1GeneProduct124 (Entrez Gene)
RetsatGeneProduct54884 (Entrez Gene)
Crabp1GeneProduct1381 (Entrez Gene)
AstaxanthinMetaboliteHMDB02204 (HMDB)
LratGeneProductENSG00000121207 (Ensembl)
ZeaxanthinMetaboliteHMDB02789 (HMDB)
Aldh1a3220 (Entrez Gene)
CanthaxanthinMetaboliteHMDB03154 (HMDB)
Sult1a16817 (Entrez Gene)
Vitamin D3MetaboliteHMDB00876 (HMDB)
Crabp2GeneProduct1382 (Entrez Gene)
MAPKGeneProduct2.7.11.24 (enzyme)
Cyp2e11571 (Entrez Gene)
Retinal Vitamin A aldehydeMetaboliteHMDB01358 (HMDB)
Dhrs3GeneProduct9249 (Entrez Gene)
Retinol dehydrogenasesGeneProduct1.1.1.105 (enzyme)
RARa5914 (Entrez Gene)
all-trans RetinalMetaboliteHMDB01358 (HMDB)
Rbp1GeneProduct5947 (Entrez Gene)
all-trans Retinol Vitamin AMetaboliteHMDB00305 (HMDB)
Cyp26b156603 (Entrez Gene)
9-cis-RetinolMetaboliteHMDB06217 (HMDB)
Rbp4GeneProduct5950 (Entrez Gene)
11-cis-RetinalMetaboliteHMDB02152 (HMDB)
Cyp26a11592 (Entrez Gene)
All-trans-13,14-dihydroretinolMetaboliteHMDB11618 (HMDB)
Bcmo1GeneProduct53630 (Entrez Gene)
13,14 dehydro RAMetabolite (HMDB)
Rdh5GeneProduct5959 (Entrez Gene)
all-transe 4-oxo RAMetabolite
Rlbp16017 (Entrez Gene)
AwatGeneProduct158835 (Entrez Gene)
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