Estrogen metabolism (Homo sapiens)

From WikiPathways

Jump to: navigation, search

Contents


Curation Tags

Description

No description


Bibliography

View all 8 references
  1. Abel EL, Lyon RP, Bammler TK, Verlinde CL, Lau SS, Monks TJ, Eaton DL; ''Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases.; ''Chem Biol Interact, 2004 - PubMed
  2. Bianco NR, Perry G, Smith MA, Templeton DJ, Montano MM; ''Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage.; ''Mol Endocrinol, 2003 - PubMed
  3. Guillemette C, Belanger A, Lepine J; ''Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview.; ''Breast Cancer Res, 2004 - PubMed
  4. Lakhani NJ, Sarkar MA, Venitz J, Figg WD; ''2-Methoxyestradiol, a promising anticancer agent.; ''Pharmacotherapy, 2003 - PubMed
  5. Shatalova EG, Walther SE, Favorova OO, Rebbeck TR, Blanchard RL; ''Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study.; ''Breast Cancer Res, 2005 - PubMed
  6. Rogan EG, Badawi AF, Devanesan PD, Meza JL, Edney JA, West WW, Higginbotham SM, Cavalieri EL; ''Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer.; ''Carcinogenesis, 2003 - PubMed
  7. Raftogianis R, Creveling C, Weinshilboum R, Weisz J; ''Estrogen metabolism by conjugation.; ''J Natl Cancer Inst Monogr, 2000 - PubMed
  8. Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, Johansson SL, Patil KD, Gross ML, Gooden JK, Ramanathan R, Cerny RL, Rogan EG; ''Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.; ''Proc Natl Acad Sci U S A, 1997 - PubMed

Categories

History

View all
CompareRevisionActionTimeUserComment
33412view14:50, 30 November 2009MaintBotRemoved group label
30275view20:34, 25 July 2009AlexanderPicofixed unsupported characters in Bibliography
30261view05:18, 25 July 2009AlexanderPicoModified categories
29863view11:06, 8 June 2009Pieter Giesbertzadded literature reference
29862view11:04, 8 June 2009Pieter Giesbertzmade some little additions
29861view10:37, 8 June 2009Pieter GiesbertzAdded literature reference
29655view09:56, 24 May 2009Pieter GiesbertzAdded literature reference
29456view09:11, 8 May 2009Pieter GiesbertzAdded literature references
29455view09:06, 8 May 2009Pieter GiesbertzAdded literature references
29454view08:56, 8 May 2009Pieter GiesbertzAdded literature references
29453view08:52, 8 May 2009Pieter GiesbertzAdded literature references
29452view08:23, 8 May 2009Pieter GiesbertzAdded literature references
29451view08:04, 8 May 2009Pieter GiesbertzAdded literature
29440view07:45, 7 May 2009Pieter GiesbertzAdded estradiol-glucuronides
29438view22:13, 6 May 2009Pieter GiesbertzAdded glucuronide metabolites
29339view15:04, 24 April 2009Pieter GiesbertzAdded compound identifiers
29325view09:52, 24 April 2009Pieter GiesbertzSpecify description
29320view13:27, 23 April 2009Pieter GiesbertzChanged CRYZ into NQO1
29319view13:13, 23 April 2009Pieter GiesbertzSpecify description
29318view12:45, 23 April 2009Pieter GiesbertzSpecify description
29317view11:57, 23 April 2009Pieter Giesbertzquinone part added
29316view11:28, 23 April 2009Pieter Giesbertzperiodical save
29279view07:36, 22 April 2009Pieter GiesbertzSpecify description
29278view23:28, 21 April 2009Pieter GiesbertzSpecify description
29229view09:15, 16 April 2009Pieter GiesbertzSpecify description
29228view14:42, 15 April 2009Pieter GiesbertzSpecify description
29227view14:37, 15 April 2009Pieter GiesbertzNew pathway

Pathway Info

DataNodes

View all 57 DataNodes

Name Type Backpage Header Database reference
Estradiol-2,3-quinoneMetabolite
EstroneMetaboliteHMDB00145 (HMDB)
4-Methoxyestrone-3-glucuronideMetabolite
2-HydroxyestradiolMetaboliteHMDB00338 (HMDB)
Estrone-3-glucuronideMetaboliteHMDB04483 (HMDB)
CYP1A1GeneProductENSG00000140465 (Ensembl Human)
Estradiol sulfateMetabolite
CYP1A2GeneProductENSG00000140505 (Ensembl Human)
OxygenMetaboliteHMDB01377 (HMDB)
CYP3A4GeneProductENSG00000160868 (Ensembl Human)
Estradiol-17-glucuronideMetabolite
4-hydroxyestradiolMetabolite
4-Methoxyestradiol-3-glucuronideMetabolite
CYP1B1GeneProductENSG00000138061 (Ensembl Human)
Estrone-3,4-semiquinoneMetabolite
16a-HydroxyestroneMetaboliteHMDB00335 (HMDB)
Estrone-3,4-quinoneMetabolite114862 (PubChem)
2-MethoxyestradiolMetaboliteHMDB00405 (HMDB)
GSTM1GeneProductENSG00000134184 (Ensembl Human)
COMTGeneProductENSG00000093010 (Ensembl Human)
UGT1A8GeneProductENSG00000167165 (Ensembl Human)
2-hydroxy-estradiol-sulfateMetabolite
2-Methoxyestrone 3-glucuronideMetaboliteHMDB04482 (HMDB)
SULT1A1GeneProductENSG00000196502 (Ensembl Human)
2-Methoxyestradiol-3-glucuronideMetabolite
2-hydroxy-estradiol-2-glucuronideMetabolite
UGT1A3GeneProduct54659 (Entrez Gene)
UGT1A1GeneProduct54658 (Entrez Gene)
EstradiolMetabolite
4-MethoxyestradiolMetaboliteHMDB00405 (HMDB)
Estradiol-3,4-quinoneMetabolite
4-hydroxy-estradiol-4-glucuronideMetabolite
Estrone-2,3-quinoneMetabolite148381 (PubChem)
4-hydroxy-estradiol-sulfateMetabolite
NQO1GeneProductENSG00000181019 (Ensembl Human)
Estrone sulfateMetaboliteHMDB01425 (HMDB)
SuperoxideMetaboliteHMDB02168 (HMDB)
SULT1E1GeneProductENSG00000109193 (Ensembl Human)
GSTA1GeneProductENSG00000187919 (Ensembl Human)
ARSDGeneProductENSG00000006756 (Ensembl Human)
Estrone-17-glucuronideMetaboliteHMDB04483 (HMDB)
ARSEGeneProductENSG00000157399 (Ensembl Human)
Estradiol-3-glucuronideMetaboliteHMDB06224 (HMDB)
2-HydroxyestroneMetaboliteHMDB00343 (HMDB)
UGT2B7GeneProductENSG00000171234 (Ensembl Human)
4-hydroxyestroneMetabolite
4-hydroxyestrone-3-glucuronideMetabolite
2-MethoxyestroneMetaboliteHMDB00010 (HMDB)
2-Hydroxyestrone-3-glucuronideMetabolite
4-MethoxyestroneMetabolite
2-hydroxyestradiol-3-glucuronideMetabolite
Estrone-2,3-semiquinoneMetabolite
4-Hydroxyestradiol-3-glucuronideMetabolite
Estradiol-3,4-semiquinoneMetabolite
UGT1A9GeneProduct54600 (Entrez Gene)
Estradiol-2,3-semiquinoneMetabolite
ARSCGeneProduct412 (Entrez Gene)
Retrieved from "http://wikipathways.org/index.php/Pathway:WP697"
Personal tools
Navigation