Epigenetic Stress Regulation (Homo sapiens)
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Description
Methylation of NR3C1 gene regulatory sequence was found in individuals that commited suicide and in rats that were treated badly at young age. Higher methylation and and lower glucocortoid receptor expression was confirmed in humans with a "bad youth". See McGowan et al. in Nat Neurosci. 2009.
Bibliography
- McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonte B, Szyf M, Turecki G, Meaney MJ; ''Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse.; ''Nat Neurosci, 2009 - PubMed
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Pathway Info
DataNodes
| Name | Type | Backpage Header | Database reference |
|---|---|---|---|
| NR3C1 | GeneProduct | NR3C1 glucocorticoid receptor | 2908 (Entrez Gene) |
| NGFI-A | GeneProduct | Nerve growth factor-induced protein A member 1 | 1958 (Entrez Gene) |
