EPO Receptor Signaling (Homo sapiens)
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Description
The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Source: Wikipedia
This pathway is based on ScienceSlides.
Bibliography
- Lacombe C, Mayeux P; ''The molecular biology of erythropoietin.; ''Nephrol Dial Transplant, 1999 - PubMed
- Zhu Y, D'Andrea AD; ''The molecular physiology of erythropoietin and the erythropoietin receptor.; ''Curr Opin Hematol, 1994 - PubMed
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Pathway Info
DataNodes
| View all 27 DataNodes |
| Name | Type | Backpage Header | Database reference |
|---|---|---|---|
| STAT5B | GeneProduct | 6777 (Entrez Gene) | |
| JAK2 | GeneProduct | 3717 (Entrez Gene) | |
| IRS2 | GeneProduct | 8660 (Entrez Gene) | |
| SRC | GeneProduct | 6714 (Entrez Gene) | |
| CD45 | GeneProduct | 5788 (Entrez Gene) |
