ACE Inhibitor Pathway (Homo sapiens)

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Description

The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists.

Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)


Comments

GenMAPP remarks 
Adapted from PharmGKB

Bibliography

  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.; ''J Pathol, 2007 - PubMed

Categories

History

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CompareRevisionActionTimeUserComment
34805view23:49, 20 January 2010KhanspersModified description
34804view23:49, 20 January 2010KhanspersDeleted reference
34803view23:43, 20 January 2010KhanspersModified description
34802view23:41, 20 January 2010KhanspersDeleted reference
34801view23:30, 20 January 2010KhanspersPeriodical save, work in progress
34800view23:18, 20 January 2010KhanspersAdded citation
34799view23:18, 20 January 2010KhanspersChanged comments
34798view23:16, 20 January 2010KhanspersModified description
32148view14:00, 14 August 2009MaintBotFixed group labels
30178view20:31, 7 July 2009KhanspersAdded xref for angiotensinII
22578view13:30, 14 November 2008Thomasremoved redundant organism name after title
21846view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:ACE-Inhibitor pathway PharmGKB]] moved to [[Pathway:WP554]]: Moved to stable identifier
14510view01:16, 23 May 2008AlexanderPicoConnected, grouped and fixed metabolites
13026view11:07, 17 May 2008MaintBotSticky edges patch by Sjoerd
11883view18:19, 8 May 2008KhanspersChanged contact info
11445view21:52, 29 March 2008JinwookPeriodical save, work in progress
10186view12:20, 15 January 2008MaintBotadded literature
7872view13:46, 7 January 2008MaintBot[[Pathway:Human:ACE-Inhibitor pathway PharmGKB]] moved to [[Pathway:Homo sapiens:ACE-Inhibitor pathway PharmGKB]]: Renaming species
7561view16:00, 18 December 2007MaintBotfixed category names
7449view12:42, 4 November 2007MaintBotAdded categories to GPML
6289view22:17, 22 May 2007C.F.ThornUploaded from wpi.php

Pathway Info

DataNodes

View all 13 DataNodes

Name Type Backpage Header Database reference
BDKRB2GeneProductBDKRB2 | bradykinin receptor B2624 (Entrez Gene)
RENGeneProductREN | renin5972 (Entrez Gene)
BradykininMetaboliteHMDB04246 (HMDB)
ACEGeneProductACE | angiotensin I converting enzyme (peptidyl...1636 (Entrez Gene)
Angiotensin IIMetaboliteHMDB01035 (HMDB)
AGTR2GeneProductAGTR2 | angiotensin II receptor type 2186 (Entrez Gene)
AGTGeneProductAGT | angiotensinogen (serine (or cysteine) pro...183 (Entrez Gene)
KNG1GeneProductKNG1 | kininogen 13827 (Entrez Gene)
ACE InhibitorMetaboliteACE Inhibitor
NOS3GeneProductNOS3 | nitric oxide synthase 3 (endothelial cel...4846 (Entrez Gene)
Angiotensin IMetabolite3081372 (PubChem)
AGTR1GeneProductAGTR1 | angiotensin II receptor type 1185 (Entrez Gene)
AldosteroneMetaboliteC01780 (Kegg Compound)
Retrieved from "http://wikipathways.org/index.php/Pathway:WP554"
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