Complement Activation, Classical Pathway (Homo sapiens)

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Description

The complement system is a biochemical cascade that helps, or “complements”, the ability of antibodies to clear pathogens from an organism. It is part of the immune system called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system. The Classical pathway of activation of the complement system is a group of blood proteins that mediate the specific antibody response. [source: Wikipedia)


Bibliography

  1. Brook E, Herbert AP, Jenkins HT, Soares DC, Barlow PN; ''Opportunities for new therapies based on the natural regulators of complement activation.; ''Ann N Y Acad Sci, 2005 - PubMed

Categories

History

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CompareRevisionActionTimeUserComment
35499view13:11, 12 February 2010MichielModified description
35496view13:09, 12 February 2010MichielAdded ref
32462view17:26, 15 August 2009MaintBotFixed text labels
32145view13:59, 14 August 2009MaintBotFixed group labels
21826view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Complement Activation Classical]] moved to [[Pathway:WP545]]: Moved to stable identifier
15395view22:31, 27 May 2008Khanspersconnectors
14776view01:17, 24 May 2008KhanspersAdded connectors and metabolite
14774view01:09, 24 May 2008KhanspersPeriodical save, work in progress
12932view10:41, 17 May 2008MaintBotSticky edges patch by Sjoerd
7966view13:46, 7 January 2008MaintBot[[Pathway:Human:Complement Activation Classical]] moved to [[Pathway:Homo sapiens:Complement Activation Classical]]: Renaming species
7607view16:03, 18 December 2007MaintBotfixed category names
7464view12:42, 4 November 2007MaintBotAdded categories to GPML
6304view22:17, 22 May 2007Nsalomonisgpml file for [[Human:Complement_Activation_Classical]]

Pathway Info

DataNodes

View all 18 DataNodes

Name Type Backpage Header Database reference
C9GeneProductC9 | complement component 9735 (Entrez Gene)
C6GeneProductC6 | complement component 6729 (Entrez Gene)
C1QBGeneProductC1QB | complement component 1 q subcomponent ...713 (Entrez Gene)
C1QAGeneProductC1QA | complement component 1 q subcomponent ...712 (Entrez Gene)
C1QGGeneProductC1QG | complement component 1 q subcomponent ...714 (Entrez Gene)
C8AGeneProductC8A | complement component 8 alpha polypeptide...731 (Entrez Gene)
C1RGeneProductC1R | complement component 1 r subcomponent715 (Entrez Gene)
C4BGeneProductC4B | complement component 4B721 (Entrez Gene)
C1SGeneProductC1S | complement component 1 s subcomponent716 (Entrez Gene)
C5GeneProductC5 | complement component 5727 (Entrez Gene)
DAFGeneProductDAF | decay accelerating factor for complement ...1604 (Entrez Gene)
C7GeneProductC7 | complement component 7730 (Entrez Gene)
MASP1GeneProductMASP1 | mannan-binding lectin serine protease 1...5648 (Entrez Gene)
C8BGeneProductC8B | complement component 8 beta polypeptide732 (Entrez Gene)
C2GeneProductC2 | complement component 2717 (Entrez Gene)
C4AGeneProductC4A | complement component 4A720 (Entrez Gene)
C3GeneProductC3 | complement component 3718 (Entrez Gene)
H2OMetaboliteHMDB02111 (HMDB)
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