Acetylcholine Synthesis (Homo sapiens)

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Description

Acetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and acetate, this is essential for proper neuronal functioning. Choline and Acetate are taken up into the cytosol and recycled for the next activation.


Bibliography

  1. Blusztajn JK, Wurtman RJ; ''Choline and cholinergic neurons.; ''Science, 1983 - PubMed

Categories

History

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CompareRevisionActionTimeUserComment
35059view10:55, 11 February 2010Thomasadded literature reference
34458view18:25, 10 December 2009MaintBotAutomatic update of empty xrefs
33205view19:29, 5 November 2009KhanspersPeriodical save, work in progress
32140view13:57, 14 August 2009MaintBotFixed group labels
29049view13:05, 27 March 2009MartijnVanIerselModified description
29048view12:57, 27 March 2009MartijnVanIerselFixed phosphorylcholine
29046view12:54, 27 March 2009MartijnVanIerselMetabolized labels
21790view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Acetylcholine Synthesis]] moved to [[Pathway:WP528]]: Moved to stable identifier
16330view12:19, 18 June 2008HubertModified description
15387view22:20, 27 May 2008Khanspersconnectors
14388view19:19, 22 May 2008KhanspersAdded connectors
14386view19:02, 22 May 2008KhanspersPeriodical save, work in progress
14384view18:52, 22 May 2008KhanspersPeriodical save, work in progress
13035view11:10, 17 May 2008MaintBotautomated metabolite conversion
7878view13:46, 7 January 2008MaintBot[[Pathway:Human:Acetylcholine Synthesis]] moved to [[Pathway:Homo sapiens:Acetylcholine Synthesis]]: Renaming species
7564view16:00, 18 December 2007MaintBotfixed category names
7325view12:42, 4 November 2007MaintBotAdded categories to GPML
6290view22:17, 22 May 2007A.Kwatest

Pathway Info

DataNodes

View all 17 DataNodes

Name Type Backpage Header Database reference
PhosphatidylcholineMetaboliteHMDB00564 (HMDB)
PDHA2GeneProductPDHA2 | pyruvate dehydrogenase (lipoamide) alph...5161 (Entrez Gene)
PhosphorylcholineMetaboliteHMDB01565 (HMDB)
PEMTGeneProductPEMT | phosphatidylethanolamine N-methyltransfe...10400 (Entrez Gene)
Acetyl CoAMetabolite72-89-9 (CAS)
PCYT1AGeneProductPCYT1A | phosphate cytidylyltransferase 1 chol...5130 (Entrez Gene)
PhosphatidylethanolamineMetaboliteHMDB01222 (HMDB)
CHKAGeneProductCHKA | choline kinase alpha1119 (Entrez Gene)
PDHA1GeneProductPDHA1 | pyruvate dehydrogenase (lipoamide) alph...5160 (Entrez Gene)
ACHEGeneProductACHE | acetylcholinesterase (YT blood group)43 (Entrez Gene)
AcetateMetabolite64-19-7 (CAS)
CHATGeneProductCHAT | choline acetyltransferase1103 (Entrez Gene)
AcetylcholineMetabolite51-84-3 (CAS)
GlycerophosphocholineMetabolite28319-77-9 (CAS)
Pyruvate from GlycolysisMetaboliteHMDB00243 (HMDB)
CholineMetabolite62-49-7 (CAS)
Cytidine diphosphate cholineMetaboliteHMDB01413 (HMDB)
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