Non-homologous end joining (Homo sapiens)

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Description

(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.


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CompareRevisionActionTimeUserComment
35395view09:48, 12 February 2010MartijnVanIerselModified description
32098view13:44, 14 August 2009MaintBotFixed group labels
29612view12:10, 23 May 2009MartijnVanIerselUpdated ensembl references
22671view14:58, 14 November 2008Thomascapitalized title
21602view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:non-homologous end joining]] moved to [[Pathway:WP438]]: Moved to stable identifier
15846view19:46, 5 June 2008KhanspersAdded gene IDs
14981view19:57, 24 May 2008AlexanderPicoGrouped and connected
9596view11:40, 9 January 2008Thomasadded to cellular process category
9588view10:18, 9 January 2008Thomasadded gene identifiers
9583view09:46, 9 January 2008Thomasmade a start with NHEJ pathway

Pathway Info

DataNodes

View all 10 DataNodes

Name Type Backpage Header Database reference
Nbs1 ?GeneProduct
DNA-PKcsGeneProductENSG00000121031 (Ensembl Human)
Ku80GeneProductENSG00000079246 (Ensembl Human)
MRE11AGeneProductENSG00000020922 (Ensembl Human)
Ku70GeneProductENSG00000196419 (Ensembl Human)
Ligase VGeneProduct
XRCC4GeneProductENSG00000152422 (Ensembl Human)
RAD50GeneProductENSG00000113522 (Ensembl Human)
XLFGeneProduct79840 (Entrez Gene)
NHEJ1GeneProductENSG00000187736 (Ensembl Human)
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