p38 MAPK Signaling Pathway (BioCarta) (Homo sapiens)

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Description

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.


Comments

GenMAPP remarks 
Converted to human by GenMAPP.org

Bibliography

View all 8 references
  1. Herlaar E, Brown Z; ''p38 MAPK signalling cascades in inflammatory disease.; ''Mol Med Today, 1999 - PubMed
  2. Ichijo H; ''From receptors to stress-activated MAP kinases.; ''Oncogene, 1999 - PubMed
  3. Kyriakis JM; ''Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses.; ''Biochem Soc Symp, 1999 - PubMed
  4. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG; ''Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry.; ''Mol Cell, 2000 - PubMed
  5. Li S, Wattenberg EV; ''Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin.; ''Toxicol Appl Pharmacol, 1999 - PubMed
  6. Roberson MS, Zhang T, Li HL, Mulvaney JM; ''Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone.; ''Endocrinology, 1999 - PubMed
  7. Tibbles LA, Woodgett JR; ''The stress-activated protein kinase pathways.; ''Cell Mol Life Sci, 1999 - PubMed
  8. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ; ''Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.; ''Proc Natl Acad Sci U S A, 1999 - PubMed

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History

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CompareRevisionActionTimeUserComment
34982view11:00, 9 February 2010Thomasmoved references in comment to bibliography
34981view10:52, 9 February 2010ThomasModified description
34980view10:51, 9 February 2010Thomasremoved "click for comments" label (leftover from GenMAPP version)
32421view17:09, 15 August 2009MaintBotFixed text labels
32079view13:39, 14 August 2009MaintBotFixed group labels
21524view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:p38 MAPK signaling pathway]] moved to [[Pathway:WP400]]: Moved to stable identifier
13959view10:53, 20 May 2008Thomasadded connectors, converted multi-line labels
12984view10:59, 17 May 2008MaintBotSticky edges patch by Sjoerd
8324view13:46, 7 January 2008MaintBot[[Pathway:Human:p38 MAPK signaling pathway]] moved to [[Pathway:Homo sapiens:p38 MAPK signaling pathway]]: Renaming species
7780view16:17, 18 December 2007MaintBotfixed category names
7322view12:42, 4 November 2007MaintBotAdded categories to GPML
6408view22:18, 22 May 2007S.Burelgpml file for [[Human:p38_MAPK_signaling_pathway]]

Pathway Info

DataNodes

View all 34 DataNodes

Name Type Backpage Header Database reference
RIPK1GeneProductRIPK1 | receptor (TNFRSF)-interacting serine-th...8737 (Entrez Gene)
RAC1GeneProductRAC1 | ras-related C3 botulinum toxin substrate...5879 (Entrez Gene)
MAP2K6GeneProductMAP2K6 | mitogen-activated protein kinase kinas...5608 (Entrez Gene)
CREB1GeneProductCREB1 | cAMP responsive element binding protein...1385 (Entrez Gene)
MAP3K9GeneProductMAP3K9 | mitogen-activated protein kinase kinas...4293 (Entrez Gene)
TGFB2GeneProductTGFB2 | transforming growth factor beta 27042 (Entrez Gene)
MAP3K7GeneProductMAP3K7 | mitogen-activated protein kinase kinas...6885 (Entrez Gene)
MAPK14GeneProductMAPK14 | mitogen-activated protein kinase 141432 (Entrez Gene)
MAP3K5GeneProductMAP3K5 | mitogen-activated protein kinase kinas...4217 (Entrez Gene)
MAP2K4GeneProductMAP2K4 | mitogen-activated protein kinase kinas...6416 (Entrez Gene)
MKNK1GeneProductMKNK1 | MAP kinase interacting serine/threonine...8569 (Entrez Gene)
HRASGeneProductHRAS | v-Ha-ras Harvey rat sarcoma viral oncoge...3265 (Entrez Gene)
MAPKAPK5GeneProductMAPKAPK5 | mitogen-activated protein kinase-act...8550 (Entrez Gene)
TRAF2GeneProductTRAF2 | TNF receptor-associated factor 27186 (Entrez Gene)
HSPB1GeneProductHSPB1 | heat shock 27kDa protein 13315 (Entrez Gene)
GRB2GeneProductGRB2 | growth factor receptor-bound protein 22885 (Entrez Gene)
MAPKAPK2GeneProductMAPKAPK2 | mitogen-activated protein kinase-act...9261 (Entrez Gene)
HMGN1GeneProductHMGN1 | high-mobility group nucleosome binding ...3150 (Entrez Gene)
ATF2GeneProductATF2 | activating transcription factor 21386 (Entrez Gene)
PLA2G4AGeneProductPLA2G4A | phospholipase A2 group IVA (cytosoli...5321 (Entrez Gene)
RPS6KA5GeneProductRPS6KA5 | ribosomal protein S6 kinase 90kDa p...9252 (Entrez Gene)
MAP3K1GeneProductMAP3K1 | mitogen-activated protein kinase kinas...4214 (Entrez Gene)
MEF2DGeneProductMEF2D | MADS box transcription enhancer factor ...4209 (Entrez Gene)
CDC42GeneProductCDC42 | cell division cycle 42 (GTP binding pro...998 (Entrez Gene)
DDIT3GeneProductDDIT3 | DNA-damage-inducible transcript 31649 (Entrez Gene)
TGFBR1GeneProductTGFBR1 | transforming growth factor beta recep...7046 (Entrez Gene)
ELK1GeneProductELK1 | ELK1 member of ETS oncogene family2002 (Entrez Gene)
TRADDGeneProductTRADD | TNFRSF1A-associated via death domain8717 (Entrez Gene)
STAT1GeneProductSTAT1 | signal transducer and activator of tran...6772 (Entrez Gene)
DAXXGeneProductDAXX | death-associated protein 61616 (Entrez Gene)
MAXGeneProductMAX | MYC associated factor X4149 (Entrez Gene)
SHC1GeneProductSHC1 | SHC (Src homology 2 domain containing) t...6464 (Entrez Gene)
MYCGeneProductMYC | v-myc myelocytomatosis viral oncogene hom...4609 (Entrez Gene)
RASGRF1GeneProductRASGRF1 | Ras protein-specific guanine nucleoti...5923 (Entrez Gene)
Retrieved from "http://wikipathways.org/index.php/Pathway:WP400"
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