p38 MAPK Signaling Pathway (Homo sapiens)
p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.
View all 8 references
- Ichijo H; ''From receptors to stress-activated MAP kinases.; ''Oncogene, 1999 - PubMed
- Li S, Wattenberg EV; ''Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin.; ''Toxicol Appl Pharmacol, 1999 - PubMed
- Herlaar E, Brown Z; ''p38 MAPK signalling cascades in inflammatory disease.; ''Mol Med Today, 1999 - PubMed
- Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ; ''Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.; ''Proc Natl Acad Sci U S A, 1999 - PubMed
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|SHC1||GeneProduct||6464 (Entrez Gene)|
|MAP2K6||GeneProduct||5608 (Entrez Gene)|
|CDC42||GeneProduct||998 (Entrez Gene)|
|MAP3K9||GeneProduct||4293 (Entrez Gene)|
|PLA2G4A||GeneProduct||5321 (Entrez Gene)|