IL-4 signaling Pathway (Homo sapiens)

From WikiPathways

Jump to: navigation, search

Contents


Curation Tags

Description

Interleukin-4 belongs to the IL-2 family of cytokines, which includes IL-2, IL-7, IL-9, IL-15 and IL-21. It signals through 2 different receptor complexes; Receptor complex 1 comprises of IL-4 receptor alpha (IL4RA) and the common gamma chain (γc), Receptor complex 2 comprises of IL4RA and IL-13 receptor alpha1. IL-4 stimulates the JAK/STAT and MAPK signaling modules.

Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_16


Comments

GenMAPP notes 
NetPath 16 - IL-4 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org

Bibliography

No bibliography


Categories

History

View all
CompareRevisionActionTimeUserComment
35643view21:32, 12 February 2010KhanspersModified description
28126view19:19, 27 January 2009KhanspersCapitalized Pathway in name
21514view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-4 NetPath 16]] moved to [[Pathway:WP395]]: Moved to stable identifier
8176view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-4 NetPath 16]] moved to [[Pathway:Homo sapiens:IL-4 NetPath 16]]: Renaming species
7708view16:11, 18 December 2007MaintBotfixed category names
7247view12:41, 4 November 2007MaintBotAdded categories to GPML
6337view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-4_NetPath_16]]

Pathway Info

DataNodes

View all 63 DataNodes

Name Type Backpage Header Database reference
IL2RGGeneProductIL2RG3561 (Entrez Gene)
IL4RGeneProductIL4R3566 (Entrez Gene)
RPS6KB1GeneProductRPS6KB16198 (Entrez Gene)
IL4GeneProductIL43565 (Entrez Gene)
NFKB1GeneProductNFKB14790 (Entrez Gene)
FESGeneProductFES2242 (Entrez Gene)
PRKCDGeneProductPRKCD5580 (Entrez Gene)
INPP5DGeneProductINPP5D3635 (Entrez Gene)
MAPK1GeneProductMAPK15594 (Entrez Gene)
PTPN6GeneProductPTPN65777 (Entrez Gene)
PIK3CAGeneProductPIK3CA5290 (Entrez Gene)
PTPN11GeneProductPTPN115781 (Entrez Gene)
STAT1GeneProductSTAT16772 (Entrez Gene)
JAK1GeneProductJAK13716 (Entrez Gene)
LCKGeneProductLCK3932 (Entrez Gene)
IRS1GeneProductIRS13667 (Entrez Gene)
STAT5AGeneProductSTAT5A6776 (Entrez Gene)
IL13RA1GeneProductIL13RA13597 (Entrez Gene)
DOK2GeneProductDOK29046 (Entrez Gene)
JAK2GeneProductJAK23717 (Entrez Gene)
BADGeneProductBAD572 (Entrez Gene)
TYK2GeneProductTYK27297 (Entrez Gene)
BCL2L1GeneProductBCL2L1598 (Entrez Gene)
PIK3R1GeneProductPIK3R15295 (Entrez Gene)
ETS1GeneProductETS12113 (Entrez Gene)
PIK3R2GeneProductPIK3R25296 (Entrez Gene)
ELK1GeneProductELK12002 (Entrez Gene)
PRKCZGeneProductPRKCZ5590 (Entrez Gene)
PRKCIGeneProductPRKCI5584 (Entrez Gene)
STAT6GeneProductSTAT66778 (Entrez Gene)
STAMGeneProductSTAM8027 (Entrez Gene)
PAWRGeneProductPAWR5074 (Entrez Gene)
CBLGeneProductCBL867 (Entrez Gene)
IRS2GeneProductIRS28660 (Entrez Gene)
SOCS5GeneProductSOCS59655 (Entrez Gene)
JAK3GeneProductJAK33718 (Entrez Gene)
MAPK3GeneProductMAPK35595 (Entrez Gene)
GRB2GeneProductGRB22885 (Entrez Gene)
RASA1GeneProductRASA15921 (Entrez Gene)
SOS1GeneProductSOS16654 (Entrez Gene)
RELAGeneProductRELA5970 (Entrez Gene)
CXCR4GeneProductCXCR47852 (Entrez Gene)
NCF1GeneProductNCF14687 (Entrez Gene)
ADRBK2GeneProductADRBK2157 (Entrez Gene)
PIK3CDGeneProductPIK3CD5293 (Entrez Gene)
PTK2GeneProductPTK25747 (Entrez Gene)
SOCS1GeneProductSOCS18651 (Entrez Gene)
SHC1GeneProductSHC16464 (Entrez Gene)
HMGA1GeneProductHMGA13159 (Entrez Gene)
PLCG1GeneProductPLCG15335 (Entrez Gene)
SOCS3GeneProductSOCS39021 (Entrez Gene)
HIST2H3CGeneProductHIST2H3C126961 (Entrez Gene)
SRCGeneProductSRC6714 (Entrez Gene)
CREBBPGeneProductCREBBP1387 (Entrez Gene)
AKT1GeneProductAKT1207 (Entrez Gene)
EP300GeneProductEP3002033 (Entrez Gene)
PRKD3GeneProductPRKD323683 (Entrez Gene)
MAPK14GeneProductMAPK141432 (Entrez Gene)
SPI1GeneProductSPI16688 (Entrez Gene)
MAPK11GeneProductMAPK115600 (Entrez Gene)
FYNGeneProductFYN2534 (Entrez Gene)
ATF2GeneProductATF21386 (Entrez Gene)
Gene SymbolGeneProductGene Symbol
Personal tools
Navigation