Apoptosis Modulation by HSP70 (Homo sapiens)

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Description

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Comments

GenMAPP remarks 
Adapted from rat by GenMAPP

Bibliography

View all 8 references
  1. Garrido C, Schmitt E, Candé C, Vahsen N, Parcellier A, Kroemer G; ''HSP27 and HSP70: potentially oncogenic apoptosis inhibitors.; ''Cell Cycle, 2003 - PubMed
  2. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B; ''The chaperone function of hsp70 is required for protection against stress-induced apoptosis.; ''Mol Cell Biol, 2000 - PubMed
  3. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES; ''Negative regulation of the Apaf-1 apoptosome by Hsp70.; ''Nat Cell Biol, 2000 - PubMed
  4. Schett G, Steiner CW, Gröger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G; ''Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70.; ''FASEB J, 1999 - PubMed
  5. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY; ''Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging.; ''FEBS Lett, 1998 - PubMed
  6. Jäättelä M, Wissing D, Kokholm K, Kallunki T, Egeblad M; ''Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.; ''EMBO J, 1998 - PubMed
  7. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci PG; ''The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.; ''J Biol Chem, 2004 - PubMed
  8. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, Garrido C; ''Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.; ''Oncogene, 2003 - PubMed

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History

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CompareRevisionActionTimeUserComment
34959view22:23, 8 February 2010KhanspersMoved lit refs from Comments to Bibliography
32416view17:07, 15 August 2009MaintBotFixed text labels
32073view13:37, 14 August 2009MaintBotFixed group labels
29910view14:04, 9 June 2009PaoloRomanoPeriodical save, work in progress
21486view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:HSP70 and Apoptosis]] moved to [[Pathway:WP384]]: Moved to stable identifier
15411view23:12, 27 May 2008Khanspersconnectors fix
14704view21:17, 23 May 2008KhanspersAdded connectors
12967view10:57, 17 May 2008MaintBotSticky edges patch by Sjoerd
8140view13:46, 7 January 2008MaintBot[[Pathway:Human:HSP70 and Apoptosis]] moved to [[Pathway:Homo sapiens:HSP70 and Apoptosis]]: Renaming species
7690view16:09, 18 December 2007MaintBotfixed category names
7232view12:41, 4 November 2007MaintBotAdded categories to GPML
6330view22:17, 22 May 2007I.Reyesgpml file for [[Human:HSP70_and_Apoptosis]]

Pathway Info

DataNodes

View all 18 DataNodes

Name Type Backpage Header Database reference
TNFRSF1AGeneProductTNFRSF1A | tumor necrosis factor receptor super...7132 (Entrez Gene)
CYCSGeneProductCYCS | cytochrome c somatic54205 (Entrez Gene)
CASP8GeneProductCASP8 | caspase 8 apoptosis-related cysteine p...841 (Entrez Gene)
MAP3K1GeneProductMAP3K1 | mitogen-activated protein kinase kinas...4214 (Entrez Gene)
CASP3GeneProductCASP3 | caspase 3 apoptosis-related cysteine p...836 (Entrez Gene)
CASP9GeneProductCASP9 | caspase 9 apoptosis-related cysteine p...842 (Entrez Gene)
FADDGeneProductFADD | Fas (TNFRSF6)-associated via death domai...8772 (Entrez Gene)
MAPK10GeneProductMAPK10 | mitogen-activated protein kinase 105602 (Entrez Gene)
BIDGeneProductBID | BH3 interacting domain death agonist637 (Entrez Gene)
PDCD8GeneProductPDCD8 | programmed cell death 8 (apoptosis-indu...9131 (Entrez Gene)
CASP2GeneProductCASP2 | caspase 2 apoptosis-related cysteine p...835 (Entrez Gene)
APAF1GeneProductAPAF1 | apoptotic protease activating factor317 (Entrez Gene)
CASP6GeneProductCASP6 | caspase 6 apoptosis-related cysteine p...839 (Entrez Gene)
NFKB1GeneProductNFKB1 | nuclear factor of kappa light polypepti...4790 (Entrez Gene)
CASP7GeneProductCASP7 | caspase 7 apoptosis-related cysteine p...840 (Entrez Gene)
RIPK1GeneProductRIPK1 | receptor (TNFRSF)-interacting serine-th...8737 (Entrez Gene)
FASGeneProductFAS | Fas (TNF receptor superfamily member 6)355 (Entrez Gene)
HSPA1AGeneProductHSPA1A | heat shock 70kDa protein 1A3303 (Entrez Gene)
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