IL-6 Signaling Pathway (Homo sapiens)

Interleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M. IL-6 signals through a ternary receptor complex consisting of IL-6 receptor alpha (IL6RA) and a homodimer of the signal transducing receptor gp130. IL-6 stimulates the association of IL6RA to gp130, which then activates the Jak/STAT, Ras/Raf/MAPK and PI 3-kinase signaling modules.

GenMAPP notes 

NetPath 18 - IL-6 signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 

http://www.netpath.org