Lung fibrosis (Mus musculus)

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Curation Tags

Description

(Nanoparticle) induced lung fibrosis pathway.

Under construction.

Note! Mouse homologues for SERPINA1 and SFTPA2 are missing and the pathway currently contains the human equivalents. Other users are encouraged to add this information when available.

Ontology Tags

 

Bibliography

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  1. Todd NW, Luzina IG, Atamas SP; ''Molecular and cellular mechanisms of pulmonary fibrosis.''; http://www.ncbi.nlm.nih.gov/pubmed/22824096, 2012 PubMed
  2. Labib S, Williams A, Yauk CL, Nikota JK, Wallin H, Vogel U, Halappanavar S; ''Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes''; http://www.ncbi.nlm.nih.gov/pubmed/26979667, 2016 PubMed
  3. Davis AP, Grondin CJ, Lennon-Hopkins K, Saraceni-Richards C, Sciaky D2, King BL, Wiegers TC2, Mattingly CJ; ''The Comparative Toxicogenomics Database's 10th year anniversary: update 2015''; http://www.ncbi.nlm.nih.gov/pubmed/25326323, 2015 PubMed
  4. Vietti G, Lison D, van den Brule S; ''Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP).''; http://www.ncbi.nlm.nih.gov/pubmed/26926090, 2016 PubMed
  5. Montojo J, Zuberi K, Rodriguez H, Bader GD, Morris Q; ''GeneMANIA: Fast gene network construction and function prediction for Cytoscape.''; http://www.ncbi.nlm.nih.gov/pubmed/25254104, 2014 PubMed
  6. Todd NW, Luzina IG, Atamas SP; ''Molecular and cellular mechanisms of pulmonary fibrosis.''; http://www.ncbi.nlm.nih.gov/pubmed/22824096, 2012 PubMed
  7. Grebe A, Latz E; ''Cholesterol crystals and inflammation.''; Curr Rheumatol Rep, 2013 PubMed
  8. Vietti G, Lison D, van den Brule S; ''Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP).''; , 2016 PubMed

History

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CompareRevisionActionTimeUserComment
88699view16:06, 12 August 2016JmeliusOntology Term : 'respiratory system disease pathway' added !
88697view16:05, 12 August 2016JmeliusOntology Term : 'pulmonary fibrosis' added !
88696view16:04, 12 August 2016JmeliusOntology Term : 'DOID:3770' removed !
88168view08:44, 29 July 2016Mkutmonunconnected line
87400view11:05, 22 July 2016MaintBotadded missing graphids
86204view08:42, 6 July 2016PennyModified description
86171view10:13, 5 July 2016FehrhartAdded homologues for some (human) gene products
86045view19:14, 28 June 2016MaintBotconnected interactions
85986view19:06, 22 June 2016KhanspersOntology Term : 'pulmonary fibrosis' added !
85025view09:47, 6 April 2016FehrhartNew pathway

External references

Datanodes

View all...
NameTypeDatabase referenceComment
ApoptosisPathwayWP254 (WikiPathways)
Atp11aGeneProductENSMUSG00000031441 (Ensembl)
Bmp7GeneProductENSMUSG00000008999 (Ensembl)
CalcaGeneProductENSMUSG00000030669 (Ensembl)
Ccl11GeneProductENSMUSG00000020676 (Ensembl)
Ccl2 GeneProductENSMUSG00000035385 (Ensembl)
Ccl3GeneProductENSMUSG00000000982 (Ensembl)
Ccl4GeneProductENSMUSG00000018930 (Ensembl)
Ccl5GeneProductENSMUSG00000035042 (Ensembl)
Ccr2GeneProductENSMUSG00000049103 (Ensembl)
Ccr3 GeneProductENSMUSG00000035448 (Ensembl)
CebpbGeneProductENSMUSG00000056501 (Ensembl)
Cma1GeneProductENSMUSG00000022225 (Ensembl)
Coagulation disturbancesPathwayWP558 (WikiPathways)
Csf2 GeneProductENSMUSG00000018916 (Ensembl)
Csf3 GeneProductENSMUSG00000038067 (Ensembl)
CtgfGeneProductENSMUSG00000019997 (Ensembl)
Cxcl15GeneProductENSMUSG00000029375 (Ensembl)
Cxcl2 GeneProductENSMUSG00000058427 (Ensembl)
Cysltr2GeneProductENSMUSG00000033470 (Ensembl)
Cytokines

and inflammatory

response
PathwayWP530 (WikiPathways)
Differentiation PathwayPathwayWP2848 (WikiPathways)
Dpp9GeneProductENSMUSG00000001229 (Ensembl)
DspGeneProductENSMUSG00000054889 (Ensembl)
Edn1GeneProductENSMUSG00000021367 (Ensembl)
Egf GeneProductENSMUSG00000028017 (Ensembl)
Elmod2GeneProductENSMUSG00000035151 (Ensembl)
ElnGeneProductENSMUSG00000029675 (Ensembl)
Fam13aGeneProductENSMUSG00000037709 (Ensembl)
Fgf1 GeneProductENSMUSG00000036585 (Ensembl)
Fgf2GeneProductENSMUSG00000037225 (Ensembl)
Fgf7GeneProductENSMUSG00000027208 (Ensembl)
Grem1GeneProductENSMUSG00000074934 (Ensembl)
HgfGeneProductENSMUSG00000028864 (Ensembl)
Hmox1 GeneProductENSMUSG00000005413 (Ensembl)
Igf1 GeneProductENSMUSG00000020053 (Ensembl)
Il12bGeneProductENSMUSG00000004296 (Ensembl)
Il13GeneProductENSMUSG00000020383 (Ensembl)
Il1bGeneProductENSMUSG00000027398 (Ensembl)
Il4GeneProductENSMUSG00000000869 (Ensembl)
Il5GeneProductENSMUSG00000036117 (Ensembl)
Il6GeneProductENSMUSG00000025746 (Ensembl)
Inflammasome activationPathwayWP288 (WikiPathways)
InflammationPathwayWP453 (WikiPathways)
MAPK signalingPathwayWP382 (WikiPathways)
Matrix metalloproteinasesPathwayWP129 (WikiPathways)
Mecp2GeneProductENSMUSG00000031393 (Ensembl)
Mmp2 GeneProductENSMUSG00000031740 (Ensembl)
Mmp9GeneProductENSMUSG00000017737 (Ensembl)
Mt2GeneProductENSMUSG00000031762 (Ensembl)
Muc5bGeneProductENSMUSG00000066108 (Ensembl)
NADPH oxidasePathwayWP3396 (WikiPathways)
NF-KBPathwayhsa04064 (KEGG Pathway)
NRF2 signalingPathwayWP2884 (WikiPathways)
Nfe2l2GeneProductENSMUSG00000015839 (Ensembl)
Obfc1GeneProductENSMUSG00000042694 (Ensembl)
Oxidative StressPathwayWP408 (WikiPathways)
ParnGeneProductENSMUSG00000022685 (Ensembl)
Pdgfa GeneProductENSMUSG00000025856 (Ensembl)
Pdgfb GeneProductENSMUSG00000000489 (Ensembl)
PlauGeneProductENSMUSG00000021822 (Ensembl)
Ptx3GeneProductENSMUSG00000027832 (Ensembl)
Rtel1GeneProductENSMUSG00000038685 (Ensembl)
SERPINA1GeneProductENSG00000197249 (Ensembl) Human gene product - no annotation for mouse yet
SFTPA2GeneProductENSG00000185303 (Ensembl) Human gene product - no annotation for mouse yet
Sftpa1GeneProductENSMUSG00000021789 (Ensembl)
SftpcGeneProductENSMUSG00000022097 (Ensembl)
Skil GeneProductENSMUSG00000027660 (Ensembl)
Smad7 GeneProductENSMUSG00000025880 (Ensembl)
Spp1GeneProductENSMUSG00000029304 (Ensembl)
TGF beta signalingPathwayWP560 (WikiPathways)
TercGeneProductENSMUSG00000064796 (Ensembl)
TertGeneProductENSMUSG00000021611 (Ensembl)
TgfaGeneProductENSMUSG00000029999 (Ensembl)
Tgfb1GeneProductENSMUSG00000002603 (Ensembl)
Timp1 GeneProductENSMUSG00000001131 (Ensembl)
TnfGeneProductENSMUSG00000024401 (Ensembl)
Toll-like receptor signalingPathwayWP75 (WikiPathways)
p38 MAPKPathwayWP400 (WikiPathways)

Annotated Interactions

No annotated interactions

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