Myometrial Relaxation and Contraction Pathways (Homo sapiens)
This pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile activity is the myometrium. Genes in this pathway are either transcribed in myometrial muscle cells or act upon the myometrium to regulate contraction. The left half of this pathway illustrates pathways of myometrial relaxation that are active throughout normal gestation. These signaling events act to suppress coordinated contractions to prevent the early onset of labor at term, largely via activation of the adenylyl-cyclase thrhough G-protein coupled receptors. On the right side of this pathway are signaling componets involved in the activation of uterine contractions at labor, in particular, activation of calcium mobilization via Oxytocin mediated binding to the Oxytocin G-protein coupled receptor. Additional genes implicated in this pathway, based on microarray expression profiling of gestation, term and postpartum of term mice are also included (e.g., Guca2b, Rdc1, Edg2) have also been included. For a detailed description of this pathway see: http://genomebiology.com/2005/6/2/R12.
- MÃ©hats C, Tanguy G, Dallot E, Cabrol D, FerrÃ© F, Leroy MJ; ''Is up-regulation of phosphodiesterase 4 activity by PGE2 involved in the desensitization of beta-mimetics in late pregnancy human myometrium?; ''J Clin Endocrinol Metab, 2001 - PubMed
- Aggelidou E, Hillhouse EW, Grammatopoulos DK; ''Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells.; ''Proc Natl Acad Sci U S A, 2002 - PubMed
- Salomonis N, Cotte N, Zambon AC, Pollard KS, Vranizan K, Doniger SW, Dolganov G, Conklin BR; ''Identifying genetic networks underlying myometrial transition to labor.; ''Genome Biol, 2005 - PubMed
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|RGS18||GeneProduct||64407 (Entrez Gene)|
|CACNB3||GeneProduct||784 (Entrez Gene)|
|MAFF||GeneProduct||23764 (Entrez Gene)|
|RLN1||GeneProduct||6013 (Entrez Gene)|
|NFKB1||GeneProduct||4790 (Entrez Gene)|