NLR proteins (Homo sapiens)

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Description

Mammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen-associated-molecular- patterns (PAMPs). NLR proteins (alternatively named NBD-LRR or CATERPILLER) represent one subclass of PRMs that have recently attracted much attention. Their cytoplasmic location differs from the classical PRMs which are mostly membrane spanning receptors (such as the Toll-like-receptors (TLRs) or lectins) and accordingly NLRs were proposed to be activated

mainly by intracellular bacterial pathogens.


Bibliography

View all 7 references
  1. Kufer TA; ''Signal transduction pathways used by NLR-type innate immune receptors.; ''Mol Biosyst, 2008 - PubMed
  2. Carneiro LA, Magalhaes JG, Tattoli I, Philpott DJ, Travassos LH; ''Nod-like proteins in inflammation and disease.; ''J Pathol, 2008 - PubMed
  3. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE; ''Nod-like proteins in immunity, inflammation and disease.; ''Nat Immunol, 2006 - PubMed
  4. Meylan E, Tschopp J, Karin M; ''Intracellular pattern recognition receptors in the host response.; ''Nature, 2006 - PubMed
  5. Mariathasan S, Monack DM; ''Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation.; ''Nat Rev Immunol, 2007 - PubMed
  6. Shaw MH, Reimer T, Kim YG, Nu�ez G; ''NOD-like receptors (NLRs): bona fide intracellular microbial sensors.; ''Curr Opin Immunol, 2008 - PubMed
  7. kufer t; ''; '',

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History

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CompareRevisionActionTimeUserComment
32385view16:57, 15 August 2009MaintBotFixed text labels
32028view13:25, 14 August 2009MaintBotFixed group labels
28883view09:41, 10 March 2009Thomasannotated some gene boxes and linked lines
27722view16:25, 14 January 2009Andi1006140109
27720view16:22, 14 January 2009Andi1006140109
27718view16:21, 14 January 2009Andi1006140109
27714view16:17, 14 January 2009Andi1006140109
27712view16:14, 14 January 2009Andi1006Periodical save, work in progress
27706view15:44, 14 January 2009Andi1006Periodical save, work in progress
27701view15:33, 14 January 2009Andi1006Periodical save, work in progress
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27695view15:06, 14 January 2009Andi1006Periodical save, work in progress
27691view14:54, 14 January 2009Andi1006more detailed
27677view13:51, 14 January 2009Andi1006Periodical save, work in progress
27673view13:41, 14 January 2009Andi1006Periodical save, work in progress
27666view13:10, 14 January 2009Andi1006Periodical save, work in progress
27663view13:07, 14 January 2009Andi1006more detailed
27661view13:00, 14 January 2009Andi1006Periodical save, work in progress
27657view12:50, 14 January 2009Andi1006Periodical save, work in progress
27655view12:42, 14 January 2009Andi1006more detailed
21285view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:NLR proteins]] moved to [[Pathway:WP288]]: Moved to stable identifier
18694view11:50, 2 September 2008KuferSpecify description
18692view11:45, 2 September 2008KuferModified categories
18690view11:44, 2 September 2008KuferModified description
18688view11:43, 2 September 2008KuferModified description
18686view11:42, 2 September 2008KuferNew pathway

Pathway Info

DataNodes

View all 14 DataNodes

Name Type Backpage Header Database reference
TAK1GeneProduct6885 (Entrez Gene)
IKKalphaGeneProduct1147 (Entrez Gene)
CARDGeneProduct
JNKGeneProduct5599 (Entrez Gene)
ERBB2IPGeneProduct55914 (Entrez Gene)
RelAGeneProduct9955 (HUGO)
TriDAPMetabolite
MAPKGeneProduct6871 (HUGO)
MDPMetabolite
NEMOGeneProduct8517 (Entrez Gene)
DAMPSMetabolite
IKKbetaGeneProduct3551 (Entrez Gene)
ERKGeneProduct2048 (Entrez Gene)
p50GeneProduct958 (Entrez Gene)
Retrieved from "http://wikipathways.org/index.php/Pathway:WP288"
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