Extracellular vesicle-mediated signaling in recipient cells (Homo sapiens)

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Protein sorting during formation of multivesicular bodies results in packaging of key molecules in exosomes. Exosomes bound-signaling ligands once released from host cells interacts with the receptors on the recipient cells to induce downstream signaling cascades pivotal in the initiation and progression of cancer. This horizontal transfer of proteomic content of exosomes can mediate signaling pathways including Wnt, PI3K and TGF-beta in recipient cells.

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Ontology Terms



  1. Gangoda L, Boukouris S, Liem M, Kalra H, Mathivanan S; ''Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?''; Proteomics, 2014 PubMed


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88052view13:46, 25 July 2016SusanOntology Term : 'signaling pathway' added !
79555view12:46, 25 March 2015ZariAdded ID for NRAS and TGFBR2 genes
78078view23:48, 30 November 2014Khanspersconnected interaction
78004view19:34, 5 November 2014AlexanderPicoclarified exsome zoom
77982view18:01, 4 November 2014KhanspersOntology Term : 'nervous system disease' added !
77981view18:00, 4 November 2014KhanspersModified description
77980view17:55, 4 November 2014KhanspersAdded lit ref
77953view19:31, 30 October 2014KhanspersOntology Term : 'cancer' added !
77952view19:30, 30 October 2014Khanspersminor edit
77951view19:28, 30 October 2014KhanspersModified description
77950view19:27, 30 October 2014KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
APCGeneProduct324 (Entrez Gene)
AXIN1GeneProduct8312 (Entrez Gene)
CD133GeneProduct8842 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
DKK4GeneProduct27121 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
ERBB2GeneProduct2064 (Entrez Gene)
HGFGeneProduct3082 (Entrez Gene)
HGFRGeneProduct4233 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
MFGE8GeneProduct4240 (Entrez Gene)
MTORGeneProduct2475 (Entrez Gene)
NRASProtein4893 (Entrez Gene)
PI3K GeneProduct23533 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
SMAD2GeneProduct4087 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SMAD4GeneProduct4089 (Entrez Gene)
TGFAGeneProduct7039 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFB2GeneProduct7042 (Entrez Gene)
TGFB3GeneProduct7043 (Entrez Gene)
TGFBR1GeneProduct7046 (Entrez Gene)
TGFBR2Protein7048 (Entrez Gene)
TGFBR3GeneProduct7049 (Entrez Gene)
TSPAN8GeneProduct7103 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)

Annotated Interactions

No annotated interactions

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