IL-7 Signaling Pathway (Homo sapiens)

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Description

Interleukin-7 belongs to a family of cytokines, which includes IL-2, IL-4, IL-9, IL-15 and IL-21. It signals through a receptor complex consisting of IL-7 receptor alpha chain (IL7RA) and a common gamma chain (γc) that is shared between all members of this family. IL-7 mainly activates the JAK/STAT signaling module.

Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_19


Comments

GenMAPP notes 
NetPath 19 – IL-7 Signaling Pathway


The annotation of immune signaling pathways (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use these pathways, you must cite these websites.

GenMAPP remarks 
http://www.netpath.org

Bibliography

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Categories

History

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CompareRevisionActionTimeUserComment
35646view21:36, 12 February 2010KhanspersModified description
21111view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-7 NetPath 19]] moved to [[Pathway:WP205]]: Moved to stable identifier
8194view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-7 NetPath 19]] moved to [[Pathway:Homo sapiens:IL-7 NetPath 19]]: Renaming species
7717view16:12, 18 December 2007MaintBotfixed category names
7256view12:41, 4 November 2007MaintBotAdded categories to GPML
6340view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-7_NetPath_19]]

Pathway Info

DataNodes

View all 46 DataNodes

Name Type Backpage Header Database reference
MCL1GeneProductMCL14170 (Entrez Gene)
IL7GeneProductIL75295 (Entrez Gene)
IL7RGeneProductIL7R3575 (Entrez Gene)
CBLGeneProductCBL867 (Entrez Gene)
JAK3GeneProductJAK33718 (Entrez Gene)
CDK4GeneProductCDK41019 (Entrez Gene)
IL2RGGeneProductIL2RG3561 (Entrez Gene)
CBLBGeneProductCBLB868 (Entrez Gene)
JAK1GeneProductJAK13716 (Entrez Gene)
HRASGeneProductHRAS3265 (Entrez Gene)
FYNGeneProductFYN2534 (Entrez Gene)
CCND2GeneProductCCND2894 (Entrez Gene)
LYNGeneProductLYN4067 (Entrez Gene)
CLTCGeneProductCLTC1213 (Entrez Gene)
STAT5AGeneProductSTAT5A6776 (Entrez Gene)
MAPK1GeneProductMAPK15594 (Entrez Gene)
STAT5BGeneProductSTAT5B6777 (Entrez Gene)
GRB2GeneProductGRB22885 (Entrez Gene)
STAT3GeneProductSTAT36774 (Entrez Gene)
MUC1GeneProductMUC14582 (Entrez Gene)
PIK3R1GeneProductPIK3R15295 (Entrez Gene)
MAP2K1GeneProductMAP2K15604 (Entrez Gene)
PTK2BGeneProductPTK2B2185 (Entrez Gene)
RB1GeneProductRB15925 (Entrez Gene)
IRS1GeneProductIRS13667 (Entrez Gene)
CCNA2GeneProductCCNA2890 (Entrez Gene)
IRS2GeneProductIRS28660 (Entrez Gene)
CDK2GeneProductCDK21017 (Entrez Gene)
AKT1GeneProductAKT1207 (Entrez Gene)
BCL2L11GeneProductBCL2L1110018 (Entrez Gene)
STAT1GeneProductSTAT16772 (Entrez Gene)
BLKGeneProductBLK640 (Entrez Gene)
STAM2GeneProductSTAM210254 (Entrez Gene)
MAPK3GeneProductMAPK35595 (Entrez Gene)
STAMGeneProductSTAM8027 (Entrez Gene)
SHC1GeneProductSHC16464 (Entrez Gene)
BAXGeneProductBAX581 (Entrez Gene)
SOS1GeneProductSOS16654 (Entrez Gene)
BADGeneProductBAD572 (Entrez Gene)
IRF1GeneProductIRF13659 (Entrez Gene)
FOXO3AGeneProductFOXO3A2309 (Entrez Gene)
Gene SymbolGeneProductGene Symbol
GSK3BGeneProductGSK3B2932 (Entrez Gene)
RAF1GeneProductRAF15894 (Entrez Gene)
FOXO1AGeneProductFOXO1A2308 (Entrez Gene)
MAP2K2GeneProductMAP2K25605 (Entrez Gene)
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