Iron metabolism in placenta (Homo sapiens)
During pregnancy, iron is transported from mother to fetus across the placenta. Iron is essential for many biological processes, including the transfer of oxygen in blood, but it can also be toxic. Elaborate and elegant mechanisms have evolved to make sure that the potential for oxidative damage is minimized. This description of Iron pathway through the placenta, and its regulation is purposed to understand the effect of Iron deficiency or Iron overload of the mother on the fetus.
View all 26 references
- Dezier JF, Vernet M, Damour O, Guillemin G, Le Treut A, Paris M, Plomteux G, Pressac M, Revenant MC, Rymer JC; ''[The coefficient of saturation of iron in transferrin].; ''Ann Biol Clin (Paris), 1988 - PubMed
- Ganz T; ''Hepcidin and iron regulation, 10 years later.; ''Blood, 2011 - PubMed
- Steere AN, Byrne SL, Chasteen ND, Mason AB; ''Kinetics of iron release from transferrin bound to the transferrin receptor at endosomal pH.; ''Biochim Biophys Acta, 2011 - PubMed
- Ohgami RS, Campagna DR, Greer EL, Antiochos B, McDonald A, Chen J, Sharp JJ, Fujiwara Y, Barker JE, Fleming MD; ''Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells.; ''Nat Genet, 2005 - PubMed
View all 17...