Thyroxine (thyroid hormone) production (Homo sapiens)
The production of the thyroid hormones thyroxine (T4),tri-iodothyronine (T3) and reverse T3 (rT3) is dependent on the organification of iodine into thyroglobulin (Tg), the major protein product of the thyroid (2). This involves thyroid peroxidase catalyzed iodination of tyrosine residues in Tg to form mono- and di-iodotyrosines and their subsequent crosslinking to form the iodothyronines T3 and T4.Iodine 131 is an important radioactive fallout product. It was released in the atmosphere after nuclear tests and after nuclear incidents like at Tchernobyl and Fukushima. Since the iodine is concentrated in the thyroid glant as a substrate for the process described here non-radioactive iodine 127 is given as competitor to people exposed.
- Ron E, Lubin JH, Shore RE, Mabuchi K, Modan B, Pottern LM, Schneider AB, Tucker MA, Boice JD Jr; ''Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies.; ''Radiat Res, 1995 - PubMed
- Van Herle, A.J ., G. Vassart, J.E . Dumont; ''Control of thyroglobulin synthesis and secretion; ''N. Engl. J. Med. 301:239, 1979 - PubMed
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|Thyroglobulin (Tg)||GeneProduct||(Entrez Gene)|
|TSH||GeneProduct||1081 (Entrez Gene)|
|Triiodothyronine (T3)||Metabolite||5707 (Chemspider)|
|127 Iodide||Metabolite||HMDB12238 (HMDB)|