Interferon gamma signaling (Homo sapiens)

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Description

Interferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by interacting with the specific IFN-gamma receptor (IFNGR). IFNGR consists of two chains, namely IFNGR1 (also known as the IFNGR alpha chain) and IFNGR2 (also known as the IFNGR beta chain). IFNGR1 is the ligand binding receptor and is required but not sufficient for signal transduction, whereas IFNGR2 do not bind IFNG independently but mainly plays a role in IFNG signaling and is generally the limiting factor in IFNG responsiveness. Both IFNGR chains lack intrinsic kinase/phosphatase activity and thus rely on other signaling proteins like Janus-activated kinase 1 (JAK1), JAK2 and Signal transducer and activator of transcription 1 (STAT-1) for signal transduction. IFNGR complex in its resting state is a preformed tetramer and upon IFNG association undergoes a conformational change. This conformational change induces the phosphorylation and activation of JAK1, JAK2, and STAT1 which in turn induces genes containing the gamma-interferon activation sequence (GAS) in the promoter.Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=877300

Ontology Tags

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
77096view08:39, 17 July 2014ReactomeTeamFixed remaining interactions
76802view12:18, 16 July 2014ReactomeTeamFixed remaining interactions
76125view10:19, 11 June 2014ReactomeTeamRe-fixing comment source
75837view11:40, 10 June 2014ReactomeTeamReactome 48 Update
75198view09:43, 9 May 2014AnweshaFixing comment source for displaying WikiPathways description
74845view10:07, 30 April 2014ReactomeTeamReactome46
44865view09:58, 6 October 2011MartijnVanIerselOntology Term : 'immune response pathway' added !
42056view21:53, 4 March 2011MaintBotAutomatic update
39862view05:53, 21 January 2011MaintBotNew pathway

External references

View all...
NameTypeDatabase referenceComment
HLA class II

histocompatibility antigen, DP [plasma

membrane]
ProteinP04440 (Uniprot-TrEMBL)
FCGRAProteinREACT_26475 (Reactome)
IFNG [extracellular region]ProteinP01579 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-7 beta chain [plasma

membrane]
ProteinP13761 (Uniprot-TrEMBL)
IFNGR1:JAK1:INFG2:JAK2ComplexREACT_25803 (Reactome)
IRF 1-9ProteinREACT_26465 (Reactome)
IFNGR1 [plasma membrane]ProteinP15260 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-10 beta chain [plasma

membrane]
ProteinQ30167 (Uniprot-TrEMBL)
JAK1 [cytosol]ProteinP23458 (Uniprot-TrEMBL)
GAS promoter region

in IFNG-regulated

genes
REACT_26763 (Reactome)
IFNGR2 [plasma membrane]ProteinP38484 (Uniprot-TrEMBL)
PMLProteinP29590 (Uniprot-TrEMBL)
JAK2 [cytosol]ProteinO60674 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DP alpha chain precursor

[plasma membrane]
ProteinP20036 (Uniprot-TrEMBL)
IFNG:IFNGR1:JAK1:IFNGR2:JAK2ComplexREACT_25865 (Reactome)
HLA class II

histocompatibility antigen, DR beta 4 chain [plasma

membrane]
ProteinP13762 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
HLA class II

histocompatibility antigen, DRB1-14 beta chain [plasma

membrane]
ProteinQ9GIY3 (Uniprot-TrEMBL)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2ComplexREACT_26738 (Reactome)
IFNG homodimerComplexREACT_26955 (Reactome)
p-Y1007-JAK2 [cytosol]ProteinO60674 (Uniprot-TrEMBL)
GBPProteinREACT_26189 (Reactome)
ADPMetaboliteCHEBI:16761 (ChEBI)
PTAFRProteinP25105 (Uniprot-TrEMBL)
IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2ComplexREACT_26286 (Reactome)
IFN-gamma upregulated CAMsProteinREACT_26072 (Reactome)
p-Y-JAK1 [cytosol]ProteinP23458 (Uniprot-TrEMBL)
IFI30(69-243)ProteinP13284 (Uniprot-TrEMBL)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2ComplexREACT_25650 (Reactome)
HLA class II

histocompatibility antigen, DQ [plasma

membrane]
ProteinP01909 (Uniprot-TrEMBL)
p-Y440-IFNGR1 [plasma membrane]ProteinP15260 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DQ beta 2 chain [plasma

membrane]
ProteinP05538 (Uniprot-TrEMBL)
STAT1-1ProteinP42224-1 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DR-1 beta chain precursor

[plasma membrane]
ProteinP01912 (Uniprot-TrEMBL)
STAT1 bound to p-IFNGR1ComplexREACT_26587 (Reactome)
HLA class II

histocompatibility antigen, DRB1-12 beta chain [plasma

membrane]
ProteinQ95IE3 (Uniprot-TrEMBL)
STAT1-1 [cytosol]ProteinP42224-1 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-16 beta chain [plasma

membrane]
ProteinQ29974 (Uniprot-TrEMBL)
p-STAT1(Y701) bound to p-IFNGR1ComplexREACT_26108 (Reactome)
HLA class II

histocompatibility antigen, DRB1-9 beta chain precursor

[plasma membrane]
ProteinQ9TQE0 (Uniprot-TrEMBL)
p-Y701-STAT1-1 [cytosol]ProteinP42224-1 (Uniprot-TrEMBL)
PTPN2-1ProteinP17706-2 (Uniprot-TrEMBL)
IFNG-activated factor (GAF)ComplexREACT_26637 (Reactome)
GAF bound to GAS promoter elementComplexREACT_25470 (Reactome)
p-S727,Y701-STAT1-1 [cytosol]ProteinP42224-1 (Uniprot-TrEMBL)
CIITAProteinP33076 (Uniprot-TrEMBL)
IFNG-activated factor (GAF)ComplexREACT_26144 (Reactome)
Class I MHC heavy chain (MHC HC)ProteinREACT_26784 (Reactome)
p-S727,Y701-STAT1-1 [nucleoplasm]ProteinP42224-1 (Uniprot-TrEMBL)
MT2AProteinP02795 (Uniprot-TrEMBL)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3ComplexREACT_26775 (Reactome)
OAS proteinsProteinREACT_26755 (Reactome)
SOCS1 [cytosol]ProteinO15524 (Uniprot-TrEMBL)
B2M(21-119)ProteinP61769 (Uniprot-TrEMBL)
SOCS3 [cytosol]ProteinO14543 (Uniprot-TrEMBL)
SP100ProteinP23497 (Uniprot-TrEMBL)
SOCS-1 and SOCS-3ProteinREACT_25587 (Reactome)
MHC class II alpha/beta dimerComplexREACT_121884 (Reactome)
PTPN6ProteinP29350 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DQ [plasma

membrane]
ProteinP01906 (Uniprot-TrEMBL)
PIAS1ProteinO75925 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DR alpha chain precursor

[plasma membrane]
ProteinP01903 (Uniprot-TrEMBL)
SUMO1ProteinP63165 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DQ [plasma

membrane]
ProteinP01920 (Uniprot-TrEMBL)
p-STAT1 dimer:PIAS:SUMO1ComplexREACT_25840 (Reactome)
HLA class II

histocompatibility antigen, DQB1*0602 beta chain precursor

[plasma membrane]
ProteinP01920 (Uniprot-TrEMBL)
PIAS1 [nucleoplasm]ProteinO75925 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DR beta 5 chain [plasma

membrane]
ProteinQ30154 (Uniprot-TrEMBL)
SUMO1 [nucleoplasm]ProteinP63165 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-1 beta chain [plasma

membrane]
ProteinP04229 (Uniprot-TrEMBL)
p-STAT1 dimer bound to p-IFNGR1ComplexREACT_25936 (Reactome)
HLA class II

histocompatibility antigen, DRB1-11 beta chain [plasma

membrane]
ProteinP20039 (Uniprot-TrEMBL)
CaMKII and PKC-deltaProteinREACT_26704 (Reactome)
HLA class II

histocompatibility antigen, DRB1-13 beta chain [plasma

membrane]
ProteinQ5Y7A7 (Uniprot-TrEMBL)
PTPN1ProteinP18031 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-15 beta chain [plasma

membrane]
ProteinP01911 (Uniprot-TrEMBL)
H2OMetaboliteCHEBI:15377 (ChEBI)
HLA class II

histocompatibility antigen, DRB1-4 beta chain [plasma

membrane]
ProteinP13760 (Uniprot-TrEMBL)
PiMetaboliteCHEBI:18367 (ChEBI)
HLA class II

histocompatibility antigen, DRB1-8 beta chain [plasma

membrane]
ProteinQ30134 (Uniprot-TrEMBL)
PTPs-SHP1/2/PTP1BProteinREACT_26675 (Reactome)
HLA class II

histocompatibility antigen, DRB3-1 beta chain precursor

[plasma membrane]
ProteinP79483 (Uniprot-TrEMBL)
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