Integrin cell surface interactions (Homo sapiens)

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Description

The extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength and also influences the behavior and differentiation state of cells in contact with it. The ECM are diverse in composition, but they generally comprise a mixture of fibrillar proteins, polysaccharides synthesized, secreted and organized by neighboring cells. Collagens, fibronectin, and laminins are the principal components involved in cell matrix interactions; other components, such as vitronectin, thrombospondin, and osteopontin, although less abundant, are also important adhesive molecules.
Integrins are the receptors that mediate cell adhesion to ECM. Integrins consists of one alpha and one beta subunit forming a noncovalently bound heterodimer. 18 alpha and 8 beta subunits have been identified in humans that combine to form 24 different receptors.
The integrin dimers can be broadly divided into three families consisting of the beta1, beta2/beta7, and beta3/alphaV integrins. beta1 associates with 12 alpha-subunits and can be further divided into RGD-, collagen-, or laminin binding and the related alpha4/alpha9 integrins that recognise both matrix and vascular ligands. beta2/beta7 integrins are restricted to leukocytes and mediate cell-cell rather than cell-matrix interactions, although some recognize fibrinogen. The beta3/alphaV family members are all RGD receptors and comprise aIIbb3, an important receptor on platelets, and the remaining b-subunits, which all associate with alphaV. It is the collagen receptors and leukocyte-specific integrins that contain alpha A-domains.

Ontology Tags

 

Bibliography

View all 82 references
  1. Wang, J, Springer, TA; ''Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses; ''Immunol Rev 163:197-215, 1998 - PubMed
  2. Nham, SU; ''Characteristics of fibrinogen binding to the domain of CD11c, an alpha subunit of p150,95; ''Biochem Biophys Res Commun 264:630-4, 1999 - PubMed
  3. Nishimura, SL, Sheppard, D, Pytela, R; ''Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain; ''J Biol Chem 269:28708-15, 1994 - PubMed
  4. Cunningham, SA, Rodriguez, JM, Arrate, MP, Tran, TM, Brock, TA; ''JAM2 interacts with alpha4beta1. Facilitation by JAM3.; ''J Biol Chem 277:27589-92, 2002 - PubMed
  5. Chada, D, Mather, T, Nollert, MU; ''The synergy site of fibronectin is required for strong interaction with the platelet integrin alphaIIbbeta3; ''Ann Biomed Eng 34:1542-52, 2006 - PubMed
  6. Busk, M, Pytela, R, Sheppard, D; ''Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein; ''J Biol Chem 267:5790-6, 1992 - PubMed
  7. Ostermann, G, Weber, KS, Zernecke, A, Schroder, A, Weber, C; ''JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes; ''Nat Immunol 3:151-8, 2002 - PubMed
  8. Conrad, C, Boyman, O, Tonel, G, Tun-Kyi, A, Laggner, U, de Fougerolles, A, Kotelianski, V, Gardner, H, Nestle, FO; ''Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis; ''Nat Med 13:836-42, 2007 - PubMed
  9. Li, Z, Calzada, MJ, Sipes, JM, Cashel, JA, Krutzsch, HC, Annis, DS, Mosher, DF, Roberts, DD; ''Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior; ''J Cell Biol 157:509-19, 2002 - PubMed
  10. Faull, RJ, Ginsberg, MH; ''Inside-out signaling through integrins; ''J Am Soc Nephrol 7:1091-7, 1996 - PubMed
  11. Wilhelmsen, K, Litjens, SH, Sonnenberg, A; ''Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis; ''Mol Cell Biol 26:2877-86, 2006 - PubMed
  12. Bax, DV, Bernard, SE, Lomas, A, Morgan, A, Humphries, J, Shuttleworth, CA, Humphries, MJ, Kielty, CM; ''Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins; ''J Biol Chem 278:34605-16, 2003 - PubMed
  13. Ben-Horin, S, Bank, I; ''The role of very late antigen-1 in immune-mediated inflammation; ''Clin Immunol 113:119-29, 2004 - PubMed
  14. Desban, N, Lissitzky, JC, Rousselle, P, Duband, JL; ''alpha1beta1-integrin engagement to distinct laminin-1 domains orchestrates spreading, migration and survival of neural crest cells through independent signaling pathways; ''J Cell Sci 119:3206-18, 2006 - PubMed
  15. Tsuji, T, Kawada, Y, Kai-Murozono, M, Komatsu, S, Han, SA, Takeuchi, K, Mizushima, H, Miyazaki, K, Irimura, T; ''Regulation of melanoma cell migration and invasion by laminin-5 and alpha3beta1 integrin (VLA-3); ''Clin Exp Metastasis 19:127-34, 2002 - PubMed
  16. Wilson, E; ''Alpha 7 beta 1 integrin: putting the brakes on smooth muscle cell proliferation; ''Circ Res 101:651-3, 2007 - PubMed
  17. Shattil, SJ; ''Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways; ''Thromb Haemost 82:318-25, 1999 - PubMed
  18. Langer, HF, Daub, K, Braun, G, Schonberger, T, May, AE, Schaller, M, Stein, GM, Stellos, K, Bueltmann, A, Siegel-Axel, D, Wendel, HP, Aebert, H, Roecken, M, Seizer, P, Santoso, S, Wesselborg, S, Brossart, P, Gawaz, M; ''Platelets recruit human dendritic cells via Mac-1/JAM-C interaction and modulate dendritic cell function in vitro; ''Arterioscler Thromb Vasc Biol 27:1463-70, 2007 - PubMed
  19. Yokosaki, Y, Monis, H, Chen, J, Sheppard, D; ''Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains; ''J Biol Chem 271:24144-50, 1996 - PubMed
  20. Yusuf-Makagiansar, H, Anderson, ME, Yakovleva, TV, Murray, JS, Siahaan, TJ; ''Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases; ''Med Res Rev 22:146-67, 2002 - PubMed
  21. Yokosaki, Y, Matsuura, N, Higashiyama, S, Murakami, I, Obara, M, Yamakido, M, Shigeto, N, Chen, J, Sheppard, D; ''Identification of the ligand binding site for the integrin alpha9 beta1 in the third fibronectin type III repeat of tenascin-C; ''J Biol Chem 273:11423-8, 1998 - PubMed
  22. Inoue, O, Suzuki-Inoue, K, McCarty, OJ, Moroi, M, Ruggeri, ZM, Kunicki, TJ, Ozaki, Y, Watson, SP; ''Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI; ''Blood 107:1405-12, 2006 - PubMed
  23. Denis, C, Williams, JA, Lu, X, Meyer, D, Baruch, D; ''Solid-phase von Willebrand factor contains a conformationally active RGD motif that mediates endothelial cell adhesion through the alpha v beta 3 receptor; ''Blood 82:3622-30, 1993 - PubMed
  24. Horton, MA; ''The alpha v beta 3 integrin "vitronectin receptor"; ''Int J Biochem Cell Biol 29:721-5, 1997 - PubMed
  25. Fontana, L, Chen, Y, Prijatelj, P, Sakai, T, Fässler, R, Sakai, LY, Rifkin, DB; ''Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1; ''FASEB J 19:1798-808, 2005 - PubMed
  26. Zhang, WM, Kapyla, J, Puranen, JS, Knight, CG, Tiger, CF, Pentikainen, OT, Johnson, MS, Farndale, RW, Heino, J, Gullberg, D; ''alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens; ''J Biol Chem 278:7270-7, 2003 - PubMed
  27. Varnum-Finney, B, Venstrom, K, Muller, U, Kypta, R, Backus, C, Chiquet, M, Reichardt, LF; ''The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C; ''Neuron 14:1213-22, 1995 - PubMed
  28. Sado, Y, Kagawa, M, Naito, I, Ueki, Y, Seki, T, Momota, R, Oohashi, T, Ninomiya, Y; ''Organization and expression of basement membrane collagen IV genes and their roles in human disorders; ''J Biochem 123:767-76, 1998 - PubMed
  29. Chen, L, Miyamura, N, Ninomiya, Y, Handa, JT; ''Distribution of the collagen IV isoforms in human Bruch's membrane; ''Br J Ophthalmol 87:212-5, 2003 - PubMed
  30. Weber, C, Fraemohs, L, Dejana, E; ''The role of junctional adhesion molecules in vascular inflammation; ''Nat Rev Immunol 7:467-77, 2007 - PubMed
  31. Chandrasekaran, L, He, CZ, Al-Barazi, H, Krutzsch, HC, Iruela-Arispe, ML, Roberts, DD; ''Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1; ''Mol Biol Cell 11:2885-900, 2000 - PubMed
  32. Emsley, J, Knight, CG, Farndale, RW, Barnes, MJ, Liddington, RC; ''Structural basis of collagen recognition by integrin alpha2beta1; ''Cell 101:47-56, 2000 - PubMed
  33. Orian-Rousseau, V, Aberdam, D, Rousselle, P, Messent, A, Gavrilovic, J, Meneguzzi, G, Kedinger, M, Simon-Assmann, P; ''Human colonic cancer cells synthesize and adhere to laminin-5. Their adhesion to laminin-5 involves multiple receptors among which is integrin alpha2beta1; ''J Cell Sci 111:1993-2004, 1998 - PubMed
  34. Lee, JH, Choi, J, Nham, SU; ''Critical residues of alphaX I-domain recognizing fibrinogen central domain; ''Biochem Biophys Res Commun 355:1058-63, 2007 - PubMed
  35. Denda, S, Reichardt, LF, Müller, U; ''Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis; ''Mol Biol Cell 9:1425-35, 1998 - PubMed
  36. Belkin, AM, Stepp, MA; ''Integrins as receptors for laminins; ''Microsc Res Tech 51:280-301, 2000 - PubMed
  37. Bengtsson, T, Aszodi, A, Nicolae, C, Hunziker, EB, Lundgren-Akerlund, E, Fässler, R; ''Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes; ''J Cell Sci 118:929-36, 2005 - PubMed
  38. Berditchevski, F, Chang, S, Bodorova, J, Hemler, ME; ''Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6.; ''J Biol Chem 272:29174-80, 1997 - PubMed
  39. Dando, J, Wilkinson, KW, Ortlepp, S, King, DJ, Brady, RL; ''A reassessment of the MAdCAM-1 structure and its role in integrin recognition; ''Acta Crystallogr D Biol Crystallogr 58:233-41, 2002 - PubMed
  40. Bayless, KJ, Meininger, GA, Scholtz, JM, Davis, GE; ''Osteopontin is a ligand for the alpha4beta1 integrin; ''J Cell Sci 111:1165-74, 1998 - PubMed
  41. Yoshida, H, Nishiura, T, Karasuno, T, Matsumura, I, Ishikawa, J, Yoshimura, M, Yokota, T, Okajima, Y, Ogawa, M, Kanakura, Y, Tomiyama, Y, Matsuzawa, Y; ''Effect of the interaction between fibronectin and VLA-4 on the proliferation of human B cells, especially a novel human B-cell line, OPM-3; ''Br J Haematol 103:804-12, 1998 - PubMed
  42. Santoso, S, Sachs, UJ, Kroll, H, Linder, M, Ruf, A, Preissner, KT, Chavakis, T; ''The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1; ''J Exp Med 196:679-91, 2002 - PubMed
  43. Piali, L, Hammel, P, Uherek, C, Bachmann, F, Gisler, RH, Dunon, D, Imhof, BA; ''CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium; ''J Cell Biol 130:451-60, 1995 - PubMed
  44. Roldán, E, García-Pardo, A, Brieva, JA; ''VLA-4-fibronectin interaction is required for the terminal differentiation of human bone marrow cells capable of spontaneous and high rate immunoglobulin secretion; ''J Exp Med 175:1739-47, 1992 - PubMed
  45. Bradfield, PF, Scheiermann, C, Nourshargh, S, Ody, C, Luscinskas, FW, Rainger, GE, Nash, GB, Miljkovic-Licina, M, Aurrand-Lions, M, Imhof, BA; ''JAM-C regulates unidirectional monocyte transendothelial migration in inflammation; ''Blood 110:2545-55, 2007 - PubMed
  46. Shiraishi, K, Tsuzaka, K, Yoshimoto, K, Kumazawa, C, Nozaki, K, Abe, T, Tsubota, K, Takeuchi, T; ''Critical role of the fifth domain of E-cadherin for heterophilic adhesion with alpha E beta 7, but not for homophilic adhesion; ''J Immunol 175:1014-21, 2005 - PubMed
  47. Giuliano, S, Nesbitt, WS, Rooney, M, Jackson, SP; ''Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase C; ''Biochem J 372:163-72, 2003 - PubMed
  48. Jones, EY, Harlos, K, Bottomley, MJ, Robinson, RC, Driscoll, PC, Edwards, RM, Clements, JM, Dudgeon, TJ, Stuart, DI; ''Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution.; ''Nature 373:539-44, 1995 - PubMed
  49. Fraemohs, L, Koenen, RR, Ostermann, G, Heinemann, B, Weber, C; ''The functional interaction of the beta 2 integrin lymphocyte function-associated antigen-1 with junctional adhesion molecule-A is mediated by the I domain; ''J Immunol 173:6259-64, 2004 - PubMed
  50. Fukuda, K, Hori, H, Utani, A, Burbelo, PD, Yamada, Y; ''Formation of recombinant triple-helical [alpha 1(IV)]2 alpha 2(IV) collagen molecules in CHO cells; ''Biochem Biophys Res Commun 231:178-82, 1997 - PubMed
  51. Arnaout, MA, Goodman, SL, Xiong, JP; ''Coming to grips with integrin binding to ligands; ''Curr Opin Cell Biol 14:641-51, 2002 - PubMed
  52. Memmo, LM, McKeown-Longo, P; ''The alphavbeta5 integrin functions as an endocytic receptor for vitronectin; ''J Cell Sci 111:425-33, 1998 - PubMed
  53. Flintoff-Dye, NL, Welser, J, Rooney, J, Scowen, P, Tamowski, S, Hatton, W, Burkin, DJ; ''Role for the alpha7beta1 integrin in vascular development and integrity; ''Dev Dyn 234:11-21, 2005 - PubMed
  54. Calzada, MJ, Annis, DS, Zeng, B, Marcinkiewicz, C, Banas, B, Lawler, J, Mosher, DF, Roberts, DD; ''Identification of novel beta1 integrin binding sites in the type 1 and type 2 repeats of thrombospondin-1; ''J Biol Chem 279:41734-43, 2004 - PubMed
  55. Tuszynski, GP, Kowalska, MA; ''Thrombospondin-induced adhesion of human platelets; ''J Clin Invest 87:1387-94, 1991 - PubMed
  56. Barry, ST, Ludbrook, SB, Murrison, E, Horgan, CM; ''A regulated interaction between alpha5beta1 integrin and osteopontin; ''Biochem Biophys Res Commun 267:764-9, 2000 - PubMed
  57. White, DJ, Puranen, S, Johnson, MS, Heino, J; ''The collagen receptor subfamily of the integrins; ''Int J Biochem Cell Biol 36:1405-10, 2004 - PubMed
  58. Tiger, CF, Fougerousse, F, Grundström, G, Velling, T, Gullberg, D; ''alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells; ''Dev Biol 237:116-29, 2001 - PubMed
  59. Buckley, CD, Doyonnas, R, Newton, JP, Blystone, SD, Brown, EJ, Watt, SM, Simmons, DL; ''Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1; ''J Cell Sci 109:437-45, 1996 - PubMed
  60. Ostermann, G, Fraemohs, L, Baltus, T, Schober, A, Lietz, M, Zernecke, A, Liehn, EA, Weber, C; ''Involvement of JAM-A in mononuclear cell recruitment on inflamed or atherosclerotic endothelium: inhibition by soluble JAM-A; ''Arterioscler Thromb Vasc Biol 25:729-35, 2005 - PubMed
  61. Kauffmann, SØ, Thomsen, AR, Christensen, JP; ''Role of very late antigen-1 in T-cell-mediated immunity to systemic viral infection; ''Scand J Immunol 63:290-8, 2006 - PubMed
  62. Farias, E, Lu, M, Li, X, Schnapp, LM; ''Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway; ''Biochem Biophys Res Commun 329:305-11, 2005 - PubMed
  63. Zhang, Z, Morla, AO, Vuori, K, Bauer, JS, Juliano, RL, Ruoslahti, E; ''The alpha v beta 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin; ''J Cell Biol 122:235-42, 1993 - PubMed
  64. Yakubenko, VP, Yadav, SP, Ugarova, TP; ''Integrin alphaDbeta2, an adhesion receptor up-regulated on macrophage foam cells, exhibits multiligand-binding properties; ''Blood 107:1643-50, 2006 - PubMed
  65. Koistinen, P, Heino, J; ''The selective regulation of alpha Vbeta 1 integrin expression is based on the hierarchical formation of alpha V-containing heterodimers; ''J Biol Chem 277:24835-41, 2002 - PubMed
  66. Nakamura, I, Duong le, T, Rodan, SB, Rodan, GA; ''Involvement of alpha(v)beta3 integrins in osteoclast function; ''J Bone Miner Metab 25:337-44, 2007 - PubMed
  67. Schnapp, LM, Hatch, N, Ramos, DM, Klimanskaya, IV, Sheppard, D, Pytela, R; ''The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin; ''J Biol Chem 270:23196-202, 1995 - PubMed
  68. Vachon, PH, Loechel, F, Xu, H, Wewer, UM, Engvall, E; ''Merosin and laminin in myogenesis; specific requirement for merosin in myotube stability and survival; ''J Cell Biol 134:1483-97, 1996 - PubMed
  69. Taooka, Y, Chen, J, Yednock, T, Sheppard, D; ''The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1; ''J Cell Biol 145:413-20, 1999 - PubMed
  70. Wu, C, Hughes, PE, Ginsberg, MH, McDonald, JA; ''Identification of a new biological function for the integrin alpha v beta 3: initiation of fibronectin matrix assembly; ''Cell Adhes Commun 4:149-58, 1996 - PubMed
  71. Desban, N, Duband, JL; ''Avian neural crest cell migration on laminin: interaction of the alpha1beta1 integrin with distinct laminin-1 domains mediates different adhesive responses; ''J Cell Sci 110:2729-44, 1997 - PubMed
  72. Bello-DeOcampo, D, Kleinman, HK, Deocampo, ND, Webber, MM; ''Laminin-1 and alpha6beta1 integrin regulate acinar morphogenesis of normal and malignant human prostate epithelial cells; ''Prostate 46:142-53, 2001 - PubMed
  73. Brakebusch, C, Fassler, R; ''beta 1 integrin function in vivo: adhesion, migration and more; ''Cancer Metastasis Rev 24:403-11, 2005 - PubMed
  74. Byzova, TV, Kim, W, Midura, RJ, Plow, EF; ''Activation of integrin alpha(V)beta(3) regulates cell adhesion and migration to bone sialoprotein; ''Exp Cell Res 254:299-308, 2000 - PubMed
  75. Yokosaki, Y, Matsuura, N, Sasaki, T, Murakami, I, Schneider, H, Higashiyama, S, Saitoh, Y, Yamakido, M, Taooka, Y, Sheppard, D; ''The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin; ''J Biol Chem 274:36328-34, 1999 - PubMed
  76. Smith, LL, Cheung, HK, Ling, LE, Chen, J, Sheppard, D, Pytela, R, Giachelli, CM; ''Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin; ''J Biol Chem 271:28485-91, 1996 - PubMed
  77. Van der Vieren, M, Crowe, DT, Hoekstra, D, Vazeux, R, Hoffman, PA, Grayson, MH, Bochner, BS, Gallatin, WM, Staunton, DE; ''The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1; ''J Immunol 163:1984-90, 1999 - PubMed
  78. Vacca, A, Ria, R, Presta, M, Ribatti, D, Iurlaro, M, Merchionne, F, Tanghetti, E, Dammacco, F; ''alpha(v)beta(3) integrin engagement modulates cell adhesion, proliferation, and protease secretion in human lymphoid tumor cells; ''Exp Hematol 29:993-1003, 2001 - PubMed
  79. Prockop, SE, Petrie, HT; ''Functional assessment of alphaEbeta7/E-cadherin interactions in the steady state postnatal thymus; ''Clin Dev Immunol 11:135-41, 2004 - PubMed
  80. Nesbitt, WS, Kulkarni, S, Giuliano, S, Goncalves, I, Dopheide, SM, Yap, CL, Harper, IS, Salem, HH, Jackson, SP; ''Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow; ''J Biol Chem 277:2965-72, 2002 - PubMed
  81. Müller, U, Bossy, B, Venstrom, K, Reichardt, LF; ''Integrin alpha 8 beta 1 promotes attachment, cell spreading, and neurite outgrowth on fibronectin; ''Mol Biol Cell 6:433-48, 1995 - PubMed
  82. Ordonez, C, Zhai, AB, Camacho-Leal, P, Demarte, L, Fan, MM, Stanners, CP; ''GPI-anchored CEA family glycoproteins CEA and CEACAM6 mediate their biological effects through enhanced integrin alpha5beta1-fibronectin interaction; ''J Cell Physiol 210:757-65, 2007 - PubMed

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History

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CompareRevisionActionTimeUserComment
44861view09:55, 6 October 2011MartijnVanIerselOntology Term : 'integrin mediated cell-cell signaling pathway' added !
42209view21:23, 7 March 2011KhanspersModified categories
40195view14:53, 16 February 2011Gillespmfigure adjustments
40189view15:34, 15 February 2011GillespmModified description
40188view15:33, 15 February 2011GillespmModified description
40187view15:32, 15 February 2011GillespmModified description
40186view15:29, 15 February 2011GillespmModified description
39859view05:53, 21 January 2011MaintBotNew pathway

External references

View all 104...

Name Type Database reference
Fibrillin-1 ProteinP35555 (UniProt)
Fibronectin ProteinP02751 (UniProt)
Magnesium Metabolite18420 (ChEBI)
Collagen type-II ComplexREACT_14196 (Reactome)
Integrin alpha1beta1 ComplexREACT_14015 (Reactome)
Integrin

alpha6beta4: Laminin-5

ComplexREACT_14260 (Reactome)
Integrin alpha1beta1:

Type IV collagen: Mg++

ComplexREACT_14130 (Reactome)
Integrin

alphaXbeta2:JAML

ComplexREACT_12224 (Reactome)
Laminin-1 (EHS

laminin)

ComplexREACT_14571 (Reactome)
JAM-A ProteinQ9Y624 (UniProt)
Integrin

alpha1beta1: Laminin-1:Mg++

ComplexREACT_14643 (Reactome)
Basigin precursor ProteinP35613 (UniProt)
Integrin alpha2beta1 ComplexREACT_2290 (Reactome)
Integrin alphaVbeta5 ComplexREACT_13993 (Reactome)
Integrin

alpha2beta1: Collagen I:Mg++

ComplexREACT_5070 (Reactome)
Integrin

alphaDbeta2:fibrin multimer:Mg++

ComplexREACT_14528 (Reactome)
Laminin-5 ComplexREACT_14602 (Reactome)
Integrin

alpha7beta1: Laminin-1

ComplexREACT_14098 (Reactome)
Alpha2beta1

complex with Laminin-5

ComplexREACT_14426 (Reactome)
Alpha 11 beta 1

integrin: Collagen type-I:Mg++ complex

ComplexREACT_13934 (Reactome)
Integrin alpha3beta1 ComplexREACT_14560 (Reactome)
Integrin

alphaMbeta2:JAM3

ComplexREACT_12228 (Reactome)
Integrin

alpha3beta1: Laminin-5

ComplexREACT_14028 (Reactome)
Integrin

alphaIIbbeta3:VWF multimer

ComplexREACT_14499 (Reactome)
Thrombospondin-1

trimer

ComplexREACT_13859 (Reactome)
Integrin

alpha4beta7: MADCAM1

ComplexREACT_11447 (Reactome)
Integrin

alpha3beta1: Thrombospondin-1

ComplexREACT_14479 (Reactome)
Vitronectin ProteinP04004 (UniProt)
VLA-4 ComplexREACT_11798 (Reactome)
Integrin alphaVbeta8 ComplexREACT_14042 (Reactome)
VLA-4:

Thrombospondin-1 complex

ComplexREACT_14539 (Reactome)
fibrin multimer ComplexREACT_4444 (Reactome)
Osteopontin ProteinP10451 (UniProt)
Integrin

alphaXbeta2:fibrin multimer

ComplexREACT_13854 (Reactome)
VLA-4:Osteopontin

complex

ComplexREACT_14112 (Reactome)
Integrin alpha7beta1 ComplexREACT_14603 (Reactome)
Fibronectin dimer ComplexREACT_14040 (Reactome)
Integrin

alpha6beta1: Laminin-1

ComplexREACT_14563 (Reactome)
VLA-4:Fibronectin

complex

ComplexREACT_14684 (Reactome)
Integrin

alpha11beta1

ComplexREACT_14514 (Reactome)
Integrin alpha5beta1 ComplexREACT_12335 (Reactome)
ICAM 1-4 ProteinREACT_11859 (Reactome)
Integrin

alpha5beta1: Ostepontin

ComplexREACT_14080 (Reactome)
Integrin

alphaMbeta2

ComplexREACT_12291 (Reactome)
Manganese Metabolite18291 (ChEBI)
Cadherin-1 ProteinP12830 (UniProt)
Integrin

alpha5beta1: Fibronectin

ComplexREACT_12353 (Reactome)
Integrin

alphaIIbbeta3: Fibronectin

ComplexREACT_14637 (Reactome)
Integrin alpha8beta1 ComplexREACT_14156 (Reactome)
Integrin

alphaIIbbeta3: Thrombospondin 1

ComplexREACT_14140 (Reactome)
Integrin

alpha8beta1: Osteopontin

ComplexREACT_13981 (Reactome)
Type IV collagen ComplexREACT_14341 (Reactome)
Integrin

alpha8beta1: Fibronectin

ComplexREACT_13847 (Reactome)
Integrin alpha6beta4 ComplexREACT_14337 (Reactome)
Tenascin hexamer ComplexREACT_14068 (Reactome)
Integrin

alpha9beta1: Tenascin

ComplexREACT_14395 (Reactome)
Integrin

alpha8beta1: Tenascin

ComplexREACT_14604 (Reactome)
Integrin

alphaVbeta3: Vitronectin

ComplexREACT_14620 (Reactome)
Integrin alphaVbeta1 ComplexREACT_13937 (Reactome)
Integrin

alphaVbeta5: Vitronectin

ComplexREACT_14045 (Reactome)
Integrin

alphaVbeta1: Fibronectin

ComplexREACT_13983 (Reactome)
Integrin

alphaVbeta8: Vitronectin

ComplexREACT_14549 (Reactome)
Integrin alphaVbeta6 ComplexREACT_14276 (Reactome)
Integrin

alphaVbeta3: Fibrillin-1

ComplexREACT_13939 (Reactome)
Integrin

alphaVbeta6: Fibronectin

ComplexREACT_14046 (Reactome)
Integrin alphaDbeta2 ComplexREACT_14521 (Reactome)
VCAM1 ProteinP19320 (UniProt)
Integrin alphaXbeta2 ComplexREACT_12091 (Reactome)
VLA-4:VCAM-1 ComplexREACT_11750 (Reactome)
Junctional adhesion

molecule-like (JAML)

ProteinQ86YT9 (UniProt)
JAM2 ProteinP57087 (UniProt)
Laminin-2 (Merosin) ComplexREACT_13824 (Reactome)
VLA-4: JAM-B ComplexREACT_12179 (Reactome)
Integrin

alpha7beta1: Laminin-2

ComplexREACT_14652 (Reactome)
Integrin alpha9beta1 ComplexREACT_14004 (Reactome)
Integrin alpha6beta1 ComplexREACT_14516 (Reactome)
Integrin

alpha9beta1: Osteopontin

ComplexREACT_14228 (Reactome)
Integrin

alpha10beta1

ComplexREACT_13998 (Reactome)
Integrin alpha9beta1:

VCAM-1

ComplexREACT_14331 (Reactome)
Integrin

alpha10beta1: Collagen type-II: Mg++

ComplexREACT_13948 (Reactome)
Integrin alphaVbeta3 ComplexREACT_13287 (Reactome)
Collagen I (alpha 1,

alpha 1, alpha 2)

ComplexREACT_2604 (Reactome)
Integrin

alphaVbeta3: Fibronectin

ComplexREACT_14178 (Reactome)
Integrin alphaLbeta2

(LFA-1)

ComplexREACT_11837 (Reactome)
Bone sialoprotein 2 ProteinP21815 (UniProt)
LFA-1:ICAM 1-4 ComplexREACT_11942 (Reactome)
Integrin

alphaVbeta3:Bone sialoprotein 2

ComplexREACT_14050 (Reactome)
LFA-1:JAM-A ComplexREACT_12182 (Reactome)
PECAM-1 ProteinP16284 (UniProt)
JAM3 ProteinQ9BX67 (UniProt)
Integrin

alphaVbeta3: PECAM-1

ComplexREACT_13361 (Reactome)
Integrin alphaEbeta7 ComplexREACT_13938 (Reactome)
VWF multimer REACT_14638 (Reactome)
Integrin

alphaEbeta7: Cadherin-1

ComplexREACT_14442 (Reactome)
Integrin

alphaVbeta3:VWF multimer

ComplexREACT_14672 (Reactome)
Integrin

alphaIIb beta3

ComplexREACT_4958 (Reactome)
Tenascin ProteinP24821 (UniProt)
Integrin alpha IIb

beta 3:Fibrin complex

ComplexREACT_4777 (Reactome)
Integrin

alphaVbeta3: Tenascin

ComplexREACT_14164 (Reactome)
Thrombospondin 1 ProteinP07996 (UniProt)
MADCAM1 ProteinQ13477-1 (UniProt)
Basigin-binding

integrins

ComplexREACT_14484 (Reactome)
Integrin alpha4beta7 ComplexREACT_11974 (Reactome)
Basigin bound to

integrins

ComplexREACT_14081 (Reactome)
Retrieved from "http://wikipathways.org/index.php/Pathway:WP1833"
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