Fatty acid, triacylglycerol, and ketone body metabolism (Homo sapiens)

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Bibliography

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Categories


History

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42160view23:26, 4 March 2011MaintBotModified categories
42040view21:52, 4 March 2011MaintBotAutomatic update
39843view05:52, 21 January 2011MaintBotNew pathway

External references

View all 160...

Name Type Database reference
Succinate Metabolite15741 (ChEBI)
ACADM

tetramer

ComplexREACT_4772 (Reactome)
GPD2 ProteinP43304 (UniProt)
Inactive

phospho-ACC 2

ProteinO00763 (UniProt)
Dihydroxyacetone

phosphate

Metabolite16108 (ChEBI)
linoleoyl-CoA Metabolite15530 (ChEBI)
FADH2 Metabolite17877 (ChEBI)
Proteins Upregulated

by PPAR-alpha

ProteinREACT_20163 (Reactome)
Glycerol-3-

phosphate

Metabolite15978 (ChEBI)
Lauroyl-CoA Metabolite15521 (ChEBI)
CoA-SH Metabolite15346 (ChEBI)
trans-Hex-2-

enoyl-CoA

Metabolite28706 (ChEBI)
Citrate Metabolite30769 (ChEBI)
ACAT1

tetramer

ComplexREACT_4071 (Reactome)
ATP Metabolite15422 (ChEBI)
TBL1XR1 ProteinQ9BZK7 (UniProt)
ADP Metabolite16761 (ChEBI)
D-methylmalonyl-

CoA

Metabolite15466 (ChEBI)
Oxaloacetate Metabolite30744 (ChEBI)
trans-Tetradec-2-

enoyl-CoA

Metabolite27721 (ChEBI)
Acetyl-CoA Metabolite15351 (ChEBI)
3-

Oxododecanoyl- CoA

Metabolite27868 (ChEBI)
Orthophos

phate

Metabolite18367 (ChEBI)
trans-Oct-2-

enoyl-CoA

Metabolite27537 (ChEBI)
Citrate lyase

homotetramer

ComplexREACT_3160 (Reactome)
Butanoyl-CoA Metabolite15517 (ChEBI)
HCO3- Metabolite17544 (ChEBI)
4-cis-decenoyl-

CoA

Metabolite29140 (ChEBI)
Malonyl-

CoA

Metabolite15531 (ChEBI)
HMGCL

dimer

ComplexREACT_4784 (Reactome)
Orthophosp

hate

Metabolite18367 (ChEBI)
Retinoid X

receptor alpha

ProteinP19793 (UniProt)
ACC1 ProteinREACT_11704 (Reactome)
PPARA:RXRA

Coactivator Complex

ComplexREACT_20439 (Reactome)
Fatty acid

synthase

ProteinP49327 (UniProt)
Proteins Upregulated

by PPAR-alpha

ProteinREACT_20403 (Reactome)
FAS

dimer

ComplexREACT_5280 (Reactome)
MUT

dimer

ComplexREACT_2476 (Reactome)
NADPH Metabolite16474 (ChEBI)
3-Oxopalmitoyl-

CoA

Metabolite15491 (ChEBI)
H+ Metabolite15378 (ChEBI)
(S)-3-

Hydroxytetradecanoyl -CoA

Metabolite27466 (ChEBI)
NADP+ Metabolite18009 (ChEBI)
(S)-3-

Hydroxydodecanoyl -CoA

Metabolite27668 (ChEBI)
Palmitate Metabolite15756 (ChEBI)
Decanoyl-CoA Metabolite28493 (ChEBI)
H2O Metabolite15377 (ChEBI)
3-Oxodecanoyl-

CoA

Metabolite28528 (ChEBI)
CO2 Metabolite16526 (ChEBI)
3-Oxooctanoyl-

CoA

Metabolite28264 (ChEBI)
AMP Metabolite16027 (ChEBI)
(S)-

Hydroxyhexanoyl- CoA

Metabolite28276 (ChEBI)
pyrophos

phate

Metabolite29888 (ChEBI)
(S)-3-

Hydroxybutanoyl- CoA

Metabolite15453 (ChEBI)
palmitoyl-

CoA

Metabolite15525 (ChEBI)
trans,cis-Lauro-

2,6-dienoyl-CoA

Metabolite28387 (ChEBI)
ACSL1 ProteinP33121 (UniProt)
3-trans-

decenoyl-CoA

Metabolite29126 (ChEBI)
ACSL3 ProteinO95573 (UniProt)
HMGCS2 ProteinP54868 (UniProt)
ACSL5 ProteinQ9ULC5 (UniProt)
BDH1

tetramer

ComplexREACT_3781 (Reactome)
ACSL6 ProteinQ9UKU0 (UniProt)
Peroxisome

Proliferator Receptor Element (PPRE)

REACT_20340 (Reactome)
Arachidonate Metabolite15843 (ChEBI)
Corepressors

of PPARalpha

ProteinREACT_19786 (Reactome)
arachidonoyl-

CoA

Metabolite15514 (ChEBI)
Fatty Acid Ligands

That Activate PPAR-alpha

MetaboliteREACT_20348 (Reactome)
ACSL4 ProteinO60488 (UniProt)
Proteins Upregulated

by PPAR-alpha

ProteinREACT_20021 (Reactome)
3-oxooctadecanoyl-

CoA

Metabolite50571 (ChEBI)
Proteins Upregulated

by PPAR-alpha

ProteinREACT_20472 (Reactome)
ELOVL1 ProteinQ9BW60 (UniProt)
Proteins Upregulated

by PPAR-alpha

ProteinREACT_19926 (Reactome)
ELOVL2 ProteinQ9NXB9 (UniProt)
L-methylmalonyl-

CoA

Metabolite15465 (ChEBI)
ELOVL3 ProteinQ9HB03 (UniProt)
SLC25A1 ProteinP53007 (UniProt)
ELOVL6 ProteinQ9H5J4 (UniProt)
FAD Metabolite16238 (ChEBI)
3-oxo-

(7,10,13,16)- docosatetraenoyl -CoA

MetaboliteREACT_22500 (Reactome)
myristoyl-CoA Metabolite15532 (ChEBI)
ELOVL5 ProteinQ9NYP7 (UniProt)
ACADL

tetramer

ComplexREACT_5750 (Reactome)
arachidoyl-

CoA

MetaboliteC02041 (COMPOUND)
3-Oxotetradecanoyl-

CoA

Metabolite28726 (ChEBI)
3-oxobehenoyl-

CoA

MetaboliteREACT_22766 (Reactome)
2-trans-

Dodecenoyl-CoA

Metabolite15471 (ChEBI)
ELOVL7 ProteinA1L3X0 (UniProt)
ECHS1

hexamer

ComplexREACT_5859 (Reactome)
tetracosanoyl-

CoA

Metabolite52974 (ChEBI)
HADH

dimer

ComplexREACT_2262 (Reactome)
3-oxocerotoyl-

CoA

MetaboliteREACT_22855 (Reactome)
trans-Dec-2-

enoyl-CoA

Metabolite10723 (ChEBI)
ELOVL4 ProteinQ9GZR5 (UniProt)
(S)-

Hydroxydecanoyl- CoA

Metabolite28325 (ChEBI)
3-

hydroxyoctadecanoyl- CoA

Metabolite50583 (ChEBI)
Octanoyl-CoA Metabolite15533 (ChEBI)
HSD17B12 ProteinQ53GQ0 (UniProt)
(S)-

Hydroxyoctanoyl- CoA

Metabolite28632 (ChEBI)
trans-octadec-2-

enoyl-CoA

Metabolite50570 (ChEBI)
Hexanoyl-CoA Metabolite27540 (ChEBI)
3-hydroxyacyl-CoA

dehydratase

REACT_22738 (Reactome)
ACADS

tetramer

ComplexREACT_5531 (Reactome)
stearoyl-CoA Metabolite15541 (ChEBI)
3-Oxohexanoyl-

CoA

Metabolite27648 (ChEBI)
TECR ProteinQ9NZ01 (UniProt)
Crotonoyl-CoA Metabolite15473 (ChEBI)
NADH Metabolite16908 (ChEBI)
acetoacetyl-CoA Metabolite15345 (ChEBI)
NAD+ Metabolite15846 (ChEBI)
cis,cis-3,6-

Dodecadienoyl- CoA

Metabolite28002 (ChEBI)
GPD1

dimer

ComplexREACT_5493 (Reactome)
DCI

dimer

ComplexREACT_2924 (Reactome)
Glycerol Metabolite17754 (ChEBI)
2-trans-4-cis-

decadienoyl-CoA

Metabolite29119 (ChEBI)
GK ProteinP32189 (UniProt)
DECR1

tetramer

ComplexREACT_4894 (Reactome)
fatty acyl CoA Metabolite37554 (ChEBI)
HMG CoA Metabolite15467 (ChEBI)
1-acyl-glycerol 3-

phosphate

Metabolite16975 (ChEBI)
acetoacetate Metabolite15344 (ChEBI)
AGPAT6 or

AGPAT9

ProteinREACT_23281 (Reactome)
D-beta

hydroxybutyrate

Metabolite17066 (ChEBI)
GPAM or

GPAT2

ProteinREACT_22523 (Reactome)
Succinyl-CoA Metabolite15380 (ChEBI)
1,2-diacyl-glycerol

3-phosphate

Metabolite29089 (ChEBI)
OXCT1

dimer

ComplexREACT_5536 (Reactome)
AGPAT1 or 2

or 3 or 4 or 5

ProteinREACT_23185 (Reactome)
Peroxisome

proliferator- activated receptor alpha

ProteinQ07869 (UniProt)
1,2-

diacylglycerol

Metabolite17815 (ChEBI)
PPARA:RXRA

Heterodimer

ComplexREACT_20362 (Reactome)
LPIN1 or

2 or 3

ProteinREACT_22496 (Reactome)
TBL1X ProteinO60907 (UniProt)
triacylglycerol Metabolite17855 (ChEBI)
PPARA:RXRA

Repressor Complex

ComplexREACT_19814 (Reactome)
DGAT1

tetramer

ComplexREACT_11651 (Reactome)
Coactivators

of PPARalpha

ProteinREACT_20313 (Reactome)
DGAT2 ProteinQ96PD7 (UniProt)
Proteins Upregulated

by PPAR-alpha

ProteinREACT_20154 (Reactome)
Carnitine Metabolite17126 (ChEBI)
Proteins Upregulated by

PPAR-alpha

ProteinREACT_20303 (Reactome)
L-Palmitoylcarnitine Metabolite17490 (ChEBI)
Proteins Upregulated

by PPAR-alpha

ProteinREACT_20238 (Reactome)
CPT1A

or B

ProteinREACT_22458 (Reactome)
Proteins Upregulated

by PPAR-alpha

ProteinREACT_19541 (Reactome)
SLC25A20 ProteinO43772 (UniProt)
Proteins Upregulated

by PPAR-alpha

ProteinREACT_19638 (Reactome)
palmitoyl-CoA Metabolite15525 (ChEBI)
propionyl-

CoA

Metabolite15539 (ChEBI)
CPT2 ProteinP23786 (UniProt)
PCCA:PCCB

complex

ComplexREACT_3520 (Reactome)
trans-Hexadec-

2-enoyl-CoA

Metabolite28935 (ChEBI)
MCEE ProteinQ96PE7 (UniProt)
ACADVL

dimer

ComplexREACT_2285 (Reactome)
(S)-Malate Metabolite30797 (ChEBI)
(S)-3-

Hydroxyhexadecanoyl- CoA

Metabolite27402 (ChEBI)
ACC2 ProteinO00763 (UniProt)
Trifunctional

Protein

ComplexREACT_5142 (Reactome)
AMPK

heterotrimer (active)

ComplexREACT_11854 (Reactome)
Retrieved from "http://wikipathways.org/index.php/Pathway:WP1817"
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