Dissolution of Fibrin Clot (Homo sapiens)
Clot dissolution is regulated in two ways. First, efficient plasmin activation and fibrinolysis occur only in complexes formed at the clot surface or on a cell membrane - proteins free in the blood are inefficient catalysts and are rapidly inactivated. Second, both plasminogen activators and plasmin itself are inactivated by specific serpins, proteins that bind to serine proteases to form stable, enzymatically inactive complexes (Kohler and Grant 2000).
These events are outlined in the drawing: black arrows connect the substrates (inputs) and products (outputs) of individual reactions, and blue lines connect output activated enzymes to the other reactions that they catalyze.
View all 25...
crosslinked:tissue plasminogen activator (one-chain): plasminogen activator inhibitor 1
plasminogen activator (two- chain):uPAR
crosslinked:tissue plasminogen activator (two-chain): plasminogen activator inhibitor 1
activator inhibitor 2