Angiogenesis (Homo sapiens)

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Description

This pathway is a concise and simplified version of the basic proteins involved in angiogenesis. The proces is regulated by hyopoxia, which results in the transcription of eg. VEGF1, FGF2, PDGFbeta, MMP9, MMP2 and Ang1. These proteins bind to their receptors and by doing this they initiate different pathways that result in vessel formation.

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Bibliography

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  1. Koblizek TI, Weiss C, Yancopoulos GD, Deutsch U, Risau W; ''Angiopoietin-1 induces sprouting angiogenesis in vitro.''; Curr Biol, 1998 PubMed
  2. Renault MA, Losordo DW; ''The matrix revolutions: matrix metalloproteinase, vasculogenesis, and ischemic tissue repair.''; Circ Res, 2007 PubMed
  3. Tomanek RJ, Sandra A, Zheng W, Brock T, Bjercke RJ, Holifield JS; ''Vascular endothelial growth factor and basic fibroblast growth factor differentially modulate early postnatal coronary angiogenesis.''; Circ Res, 2001 PubMed
  4. Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D; ''Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis.''; Nat Cell Biol, 2000 PubMed
  5. Novotny NM, Lahm T, Markel TA, Crisostomo PR, Wang M, Wang Y, Tan J, Meldrum DR; ''Angiopoietin-1 in the treatment of ischemia and sepsis.''; Shock, 2009 PubMed
  6. http://www.cst.neb.com/reference/pathway/Angiogenesis.html.; ''Angiogenesis Pathway''; http://www.cst.neb.com/reference/pathway/Angiogenesis.html., 2008
  7. Madeddu P; ''Therapeutic angiogenesis and vasculogenesis for tissue regeneration.''; Exp Physiol, 2005 PubMed
  8. ''3: Angiogenesis Pathway''; http://www.cst.neb.com/reference/pathway/Angiogenesis.html, 2008
  9. Millauer B, Wizigmann-Voos S, Schnâˆڑأ‰آ¬آ؛rch H, Martinez R, Mâˆڑأ‰آ¬âˆڈller NP, Risau W, Ullrich A; ''High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.''; Cell, 1993 PubMed
  10. Burbridge MF, Cogâˆڑأ‰آ¬آ© F, Galizzi JP, Boutin JA, West DC, Tucker GC; ''The role of the matrix metalloproteinases during in vitro vessel formation.''; Angiogenesis, 2002 PubMed
  11. Kutryk MJ, Stewart DJ; ''Angiogenesis of the heart.''; Microsc Res Tech, 2003 PubMed
  12. Li J, Wei Y, Liu K, Yuan C, Tang Y, Quan Q, Chen P, Wang W, Hu H, Yang L; ''Synergistic effects of FGF-2 and PDGF-BB on angiogenesis and muscle regeneration in rabbit hindlimb ischemia model.''; Microvasc Res, 2010 PubMed
  13. Tomanek RJ, Zheng W, Yue X; ''Growth factor activation in myocardial vascularization: therapeutic implications.''; Mol Cell Biochem, 2004 PubMed
  14. Hellberg C, Ostman A, Heldin CH; ''PDGF and vessel maturation.''; Recent Results Cancer Res, 2010 PubMed

History

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CompareRevisionActionTimeUserComment
88983view09:51, 18 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
79949view10:53, 28 April 2015ZariChanged Drosophila ID to human ID for p38 MAPK
78807view09:16, 31 January 2015EgonwAccidental commit; reverting, just in case.
78806view09:15, 31 January 2015EgonwWP254
78805view09:14, 31 January 2015EgonwConnected a dot (by adding an invisible box).
75222view22:04, 9 May 2014Khanspersfixed connections and groups
74474view04:33, 25 April 2014EgonwFixed a PubMed ID.
71713view20:05, 17 October 2013MaintBotUpdated UniProt/TrEMBL data source
63161view20:19, 8 May 2013MaintBotUpdating GPML version
59198view19:08, 22 February 2013MaintBotUpdated Ensembl data source
58504view18:59, 14 February 2013MaintBotModified description
44952view12:37, 6 October 2011MartijnVanIerselOntology Term : 'signaling pathway pertinent to development' added !
42601view20:32, 10 April 2011AlexanderPicoupdated HIF1B to ARNT
42554view14:01, 4 April 2011ToxlabProvided entrez Gene ID for FGFR2
42553view13:43, 4 April 2011ToxlabAdded data base ref to FGF2
41185view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
38974view18:27, 25 September 2010AlexanderPicofixed groups, labels and lines
38945view23:09, 24 September 2010KhanspersFixed data nodes
38944view23:03, 24 September 2010KhanspersChanged cell compartments
37853view18:22, 12 July 2010KhanspersModified categories
37640view15:30, 14 June 2010LauraSSpecify description
37639view15:22, 14 June 2010LauraSModified description
37638view15:21, 14 June 2010LauraSModified description
37637view15:05, 14 June 2010LauraSSpecify description
37636view14:55, 14 June 2010LauraSPeriodical save, work in progress
37635view14:45, 14 June 2010LauraSPeriodical save, work in progress
37631view14:31, 14 June 2010LauraSSpecify description
37630view14:30, 14 June 2010LauraSSpecify description
37627view14:11, 14 June 2010LauraSSpecify description
37626view14:08, 14 June 2010LauraS14-06-2010
37624view14:00, 14 June 2010LauraS14-06-2010
37622view13:55, 14 June 2010LauraSPeriodical save, work in progress
37621view13:44, 14 June 2010LauraSPeriodical save, work in progress
37620view13:34, 14 June 2010LauraSPeriodical save, work in progress
37619view13:24, 14 June 2010LauraSPeriodical save, work in progress
37618view13:14, 14 June 2010LauraSPeriodical save, work in progress
37617view13:03, 14 June 2010LauraSPeriodical save, work in progress
37616view12:53, 14 June 2010LauraSPeriodical save, work in progress
37615view12:43, 14 June 2010LauraSPeriodical save, work in progress
37614view12:33, 14 June 2010LauraSPeriodical save, work in progress
37222view16:00, 22 May 2010LauraSSpecify description
37221view15:29, 22 May 2010LauraSPeriodical save, work in progress
37220view15:19, 22 May 2010LauraSPeriodical save, work in progress
37219view15:09, 22 May 2010LauraSPeriodical save, work in progress
37209view20:27, 21 May 2010LauraSVesselformation
37208view20:19, 21 May 2010LauraSPeriodical save, work in progress
37207view19:58, 21 May 2010LauraSPeriodical save, work in progress
37206view19:48, 21 May 2010LauraSPeriodical save, work in progress
37205view19:38, 21 May 2010LauraSPeriodical save, work in progress
37204view19:28, 21 May 2010LauraSPeriodical save, work in progress

External references

Datanodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
ARNTGeneProduct405 (Entrez Gene)
Ang 1GeneProductQ15389 (Uniprot-TrEMBL)
CBPGeneProduct1387 (Entrez Gene)
FAKGeneProductQ05397 (Uniprot-TrEMBL)
FGF2GeneProductENSG00000138685 (Ensembl)
FGFR2GeneProduct2263 (Entrez Gene)
FLT1GeneProductENSG00000102755 (Ensembl)
HIF1AGeneProduct3091 (Entrez Gene)
MAPK1GeneProductENSG00000100030 (Ensembl)
MMP2GeneProductENSG00000100985 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
NOSGeneProductENSG00000164867 (Ensembl)
PDGFBGeneProductENSG00000100311 (Ensembl)
PDGFRAGeneProductP16234 (Uniprot-TrEMBL)
PI3KGeneProduct5290 (Entrez Gene)
PLCG1GeneProductENSG00000124181 (Ensembl)
SMAD1GeneProductENSG00000170365 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
TIE2GeneProduct7010 (Entrez Gene)
TIMP2GeneProductENSG00000035862 (Ensembl)
TIMP3ProteinENSG00000100234 (Ensembl)
VEGFAGeneProductP15692 (Uniprot-TrEMBL)
VEGFR2GeneProduct3791 (Entrez Gene)
p38 MAPKGeneProduct1432 (Entrez Gene)
sTIE2GeneProduct7010 (Entrez Gene)

Annotated Interactions

No annotated interactions

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