Selenium Micronutrient Network (Homo sapiens)

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History

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73505view23:16, 29 January 2014KhanspersModified title
73504view23:14, 29 January 2014KhanspersModified title
73357view04:57, 23 January 2014MaintBotfixed character representation of hyphen in gpml
72365view09:35, 13 November 2013EgonwFixed the type of two proteins.
71706view19:58, 17 October 2013MaintBotUpdated data sources
70119view19:19, 12 July 2013MaintBotupdated to 2013 schema
68043view11:14, 29 June 2013EgonwAdded two missing metabolite identifiers.
68041view11:08, 29 June 2013EgonwUndo revision 68036 by [[Special:Contributions/Egonw|Egonw]] ([[User talk:Egonw|Talk]])
68040view11:07, 29 June 2013EgonwUndo revision 68037 by [[Special:Contributions/Egonw|Egonw]] ([[User talk:Egonw|Talk]])
68039view11:06, 29 June 2013EgonwUndo revision 68038 by [[Special:Contributions/Egonw|Egonw]] ([[User talk:Egonw|Talk]])
68038view11:02, 29 June 2013EgonwRemoved a few empty, unlinked gene product data nodes.
68037view10:58, 29 June 2013EgonwRemoved an empty unlinked 'protein'.
68036view10:57, 29 June 2013EgonwRemoved an empty unlinked 'metabolite'.
68035view10:49, 29 June 2013EgonwFixed EC number data source.
61689view22:06, 16 April 2013MaintBotremoved data source without identifer
56489view09:45, 8 January 2013EgonwFixed DataNode @Type from Metabolite to Protein for those with an Entrez Gene identifier.
54708view14:04, 7 December 2012AndraRDF Tidy
48242view06:08, 17 May 2012MaintBotUpdating PubChem xrefs
48216view05:28, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45021view18:39, 6 October 2011ThomasOntology Term : 'selenoamino acid metabolic pathway' added !
41123view23:37, 1 March 2011MaintBotRemoved redundant pathway information and comments
39765view07:48, 17 January 2011AlexanderPicomore complete title
39430view08:51, 30 November 2010Thomasfixed xrefs (removed trailing white space)
38764view23:14, 23 September 2010KhanspersReverted to version '22:16, 21 December 2009' by Khanspers
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33309view14:18, 23 November 2009Damarizcox1

External references

View all...
NameTypeDatabase referenceComment
GSRProtein2936 (Entrez Gene)
  • EC 1.8.1.7
  • glutathione reductase
PGE3MetaboliteHMDB02664 (HMDB) Prostaglandin E3
AscorbateMetabolite38290 (ChEBI)
Metabolite
ATPMetaboliteHMDB00538 (HMDB) Adenosine triphosphate
Lipoxin B4MetaboliteHMDB05082 (HMDB)
SelHProtein280636 (Entrez Gene) Selenoprotein-selenoprotein H-chromosome 11 open reading frame 31
RELAGeneProduct5970 (Entrez Gene) nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
HDL-CMetabolite47775 (ChEBI) high-density lipoprotein cholesterol
ALAMetaboliteHMDB01388 (HMDB) Alpha-Linolenic acid
FibrinogenProteinGO:0005577 (Other)
8-Isoprostaglandin F2aMetaboliteHMDB05083 (HMDB)
PRDX4Protein10549 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 4
DGLAMetaboliteHMDB02925 (HMDB)
  • Dihomo-gamma-linolenic acid
  • 8,11,14-Eicosatrienoic acid
DIO1Protein1733 (Entrez Gene)
  • EC 1.97.1.10
  • Selenoprotein-deiodinase, iodothyronine, type I
COX2Protein5743 (Entrez Gene)
  • EC 1.14.99.1
  • Cyclooxygenase 2
  • COX-2 inducible
HDLMetabolite39025 (ChEBI) high-density lipoprotein
COX1Protein5742 (Entrez Gene)
  • EC 1.14.99.1
  • Cyclooxygenase 1
  • COX-1 constitutive
8-OHdGMetaboliteHMDB03333 (HMDB) 8-Hydroxy-deoxyguanosine
Lipoxin A4MetaboliteHMDB04385 (HMDB)
NO2Metabolite33101 (ChEBI) Nitrogen dioxide
F2-IsoprostaneMetabolite53788444 (PubChem-substance)
IL10Protein3458 (Entrez Gene) interferon, gamma
EPAMetaboliteHMDB01999 (HMDB) Eicosapentaenoic acid
FructosamineMetaboliteHMDB02030 (HMDB)
PGI2MetaboliteHMDB01335 (HMDB) Prostaglandin I2
RNSMetaboliteReactive nitrogen species (Wikipedia)
  • reactive nitrogen species
  • http://en.wikipedia.org/wiki/Reactive_nitrogen_species
Thromboxane B2MetaboliteHMDB03252 (HMDB)
DIO2Protein1734 (Entrez Gene)
  • EC 1.97.1.10
  • Selenoprotein-deiodinase, iodothyronine, type II
DPAMetaboliteHMDB01976 (HMDB) Docosapentaenoic acid
SerineMetaboliteHMDB00187 (HMDB)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
APOA1Protein335 (Entrez Gene) apolipoprotein A-I
a-TocopherolMetaboliteHMDB01893 (HMDB)
APOBProtein338 (Entrez Gene) apolipoprotein B
Linoleic acidMetaboliteHMDB00673 (HMDB)
oxLDLMetabolite39026 (ChEBI) oxidized low-density lipoprotein
NFkB2GeneProduct4791 (Entrez Gene) nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
ChlorineMetaboliteHMDB00492 (HMDB)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
DHAMetaboliteHMDB02183 (HMDB) Docosahexaenoic acid
D-dimerProteinhttp://en.wikipedia.org/wiki/Fibrin_degradation_product
NFkB1GeneProduct4790 (Entrez Gene) nuclear factor NF-kappa-B p50 subunit
HBA1Protein3039 (Entrez Gene) hemoglobin, alpha 1
PGF2aMetaboliteHMDB01139 (HMDB) Prostaglandin F2a
HBBProtein3043 (Entrez Gene) hemoglobin, beta
PGH3MetaboliteHMDB13040 (HMDB) Prostaglandin H3
Trx-(SH)2Protein7295 (Entrez Gene) reduced thioredoxin
MDAMetaboliteHMDB06112 (HMDB) Malondialdehyde
TRXR3Protein114112 (Entrez Gene)
  • EC 1.8.1.9
  • Selenoprotein-thioredoxin reductase 3
PGG2MetaboliteHMDB03235 (HMDB) Prostaglandin G2
HomocysteineMetaboliteHMDB00742 (HMDB)
PGH2MetaboliteHMDB01381 (HMDB) Prostaglandin H2
SelIProtein85465 (Entrez Gene)
  • Selenoprotein-selenoprotein I
  • Unknown function
PGE1MetaboliteHMDB01442 (HMDB) Prostaglandin E1
SPS2Protein22928 (Entrez Gene)
  • EC2.7.9.3
  • Selenoprotein-selenophosphate synthetase 2
PGE2MetaboliteHMDB01220 (HMDB) Prostaglandin E2
SelSProtein55829 (Entrez Gene) Selenoprotein-selenoprotein S
KynurenineMetaboliteHMDB00684 (HMDB)
SOD1Protein6647 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 1, soluble
MTRProtein4548 (Entrez Gene)
  • EC 2.1.1.13
  • 5-methyltetrahydrofolate-homocysteine methyltransferase
HypoxanthineMetaboliteHMDB00157 (HMDB)
TRXR1Protein7296 (Entrez Gene) Selenoprotein-thioredoxin reductase 1
TAGMetabolite17855 (ChEBI)
  • Triglyceride
  • Triacylglycerol
CBSProtein875 (Entrez Gene)
  • EC 4.2.1.22
  • cystathionine-beta-synthase
CholesterolMetaboliteHMDB00067 (HMDB)
IodineMetaboliteHMDB00464 (HMDB)
ACTProtein12 (Entrez Gene)
  • alpha-1-antichymotrypsin
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
KMOProtein8564 (Entrez Gene)
  • EC 1.14.13.9
  • kynurenine 3-hydroxylase
SAA4Protein6291 (Entrez Gene) serum amyloid A4, constitutive
R-Triiodothyronine (rT3)Metabolite28774 (ChEBI) Reverse triiodothyronine
SRB1Protein949 (Entrez Gene) scavenger receptor class B, member 1
5-HPETEMetaboliteHMDB01193 (HMDB) 5(S)-Hydroperoxyeicosatetraenoic acid
APOA1-NO2TyrProtein335 (Entrez Gene) Nitrotyrosinated apolipoprotein A-I
15-HETEMetaboliteHMDB03876 (HMDB) 15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
ADPMetaboliteHMDB01341 (HMDB) Adenosine diphosphate
5-HETEMetaboliteHMDB11134 (HMDB) 5-hydroxyeicosatetraenoic acid
SOD2Protein6648 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 2, mitochondrial
Thyroxine (T4)Metabolite30660 (ChEBI)
GSSGMetaboliteHMDB00656 (HMDB) Glutathione disulfide
Triiodothyronine (T3)Metabolite18258 (ChEBI)
PMPMetaboliteHMDB01555 (HMDB) Pyridoxamine 5'-phosphate
5,6-EpoxytetraeneMetaboliteC14815 (KEGG Compound)
NOMetaboliteHMDB03378 (HMDB) Nitric oxide
NADP+MetaboliteHMDB00217 (HMDB) Nicotinamide adenine dinucleotide phosphate-Oxidized
TNFaProtein7124 (Entrez Gene) tumor necrosis factor (TNF superfamily, member 2)
MPOProtein4353 (Entrez Gene)
  • EC 1.11.1.7
  • Myeloperoxidase
INSRProtein3643 (Entrez Gene) Insulin receptor
CatalaseProtein847 (Entrez Gene) EC 1.11.1.6
IFNgProtein3458 (Entrez Gene) interferon, gamma
Uric acidMetaboliteHMDB00289 (HMDB)
INSProtein3630 (Entrez Gene) Insulin
CysteineMetaboliteHMDB00574 (HMDB)
SelWProtein6415 (Entrez Gene) Selenoprotein-selenoprotein W
ThrombinProtein2147 (Entrez Gene)
  • EC 3.4.21.5
  • coagulation factor II (thrombin)
XanthineMetaboliteHMDB00292 (HMDB)
PAI-1Protein5054 (Entrez Gene) Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
ONOO-/ONOOHMetaboliteHMDB02179 (HMDB) Peroxynitrite
PLGProtein5340 (Entrez Gene)
  • EC 3.4.21.7
  • Plasminogen
GlucoseMetaboliteHMDB00122 (HMDB)
tPAProtein5327 (Entrez Gene)
  • EC 3.4.21.68
  • plasminogen activator, tissue
PGD2MetaboliteHMDB01403 (HMDB) Prostaglandin D2
Factor VIIProtein2155 (Entrez Gene)
  • EC 3.4.21.21
  • coagulation factor VII (serum prothrombin conversion accelerator)
GPX 1Protein2876 (Entrez Gene)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 1
GGT1Protein2678 (Entrez Gene)
  • EC 2.3.2.2
  • gamma-glutamyltransferase 1
ROSMetabolite26523 (ChEBI)
  • reactive oxygen species
  • http://en.wikipedia.org/wiki/Reactive_Oxygen_Species
GPX 4Protein2879 (Entrez Gene)
  • EC 1.11.1.12
  • Selenoprotein-glutathione peroxidase 4
MTHFRProtein4524 (Entrez Gene)
  • EC 1.5.1.20
  • 5,10-methylenetetrahydrofolate reductase
TRXR2Protein10587 (Entrez Gene)
  • EC 1.8.1.9
  • Selenoprotein-thioredoxin reductase 2
SelTProtein51714 (Entrez Gene) Selenoprotein-selenoprotein T
Xantine oxidaseProtein7498 (Entrez Gene)
  • EC 1.17.3.2
  • http://en.wikipedia.org/wiki/Xanthine_oxidase
SelVProtein348303 (Entrez Gene)
  • Selenoprotein-selenoprotein V
  • Unknown function
PRDX5Protein25824 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 5
DIO3Protein1735 (Entrez Gene)
  • EC 1.97.1.11
  • Selenoprotein-deiodinase, iodothyronine type III
H2O2MetaboliteHMDB03125 (HMDB) Hydrogen peroxide
SelMProtein140606 (Entrez Gene) Selenoprotein-selenoprotein M
ALOX15BProtein247 (Entrez Gene)
  • EC 1.13.11.33
  • arachidonate 15-lipoxygenase, type B
SelNProtein57190 (Entrez Gene) Selenoprotein-selenoprotein N, 1
ALOX5Protein240 (Entrez Gene)
  • EC 1.13.11.34
  • arachidonate 5-lipoxygenase
SelOProtein83642 (Entrez Gene)
  • Selenoprotein-selenoprotein O
  • Unknown function
CopperMetaboliteHMDB00657 (HMDB)
Pyridoxal 5'-phosphateMetaboliteHMDB01491 (HMDB)
Vitamin B12MetaboliteHMDB02174 (HMDB)
IronMetaboliteHMDB00464 (HMDB)
5,10-Methylene-THFMetaboliteHMDB01533 (HMDB) 5,10-Methylenetetrahydrofolate
PRDX3Protein10935 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 3
SelRProtein51734 (Entrez Gene)
  • EC 1.8.4.-
  • Selenoprotein-selenoprotein X
LDLRProtein3949 (Entrez Gene) low density lipoprotein receptor
TryptophanMetaboliteHMDB00929 (HMDB)
LDLMetabolite39026 (ChEBI) low-density lipoprotein
5-methyl-THFMetaboliteHMDB01396 (HMDB) 5-methyltetrahydrofolate
HDL/APOA1Metabolite39025 (ChEBI)
  • high-density lipoprotein
  • ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles
SOD3Protein6649 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 3, extracellular
HDL/SAAMetabolite39025 (ChEBI)
  • high-density lipoprotein
  • SAA circulates in plasma as a constituent of high density lipoproteins (HDL).
PRDX1Protein5052 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 1
VLDL/APOBMetabolite39027 (ChEBI)
  • very-low-density lipoprotein
  • The VLDL is produced in the liver, contains one molecule of apoB100
RFKProtein55312 (Entrez Gene)
  • EC 2.7.1.26
  • riboflavin kinase
VLDLMetabolite39027 (ChEBI) very-low-density lipoprotein
H2OMetaboliteHMDB02111 (HMDB) Glutathione disulfide
ABCA1Protein19 (Entrez Gene) ATP-binding cassette, sub-family A (ABC1), member 1
GPX 3Protein2878 (Entrez Gene) Selenoprotein-glutathione peroxidase 3
VLDL-TAGMetabolite47776 (ChEBI)
  • very-low-density lipoprotein-triglyceride
  • Triglyceride transport
NiacinamideMetaboliteHMDB01406 (HMDB)
SAA3Protein6290 (Entrez Gene) serum amyloid A3 pseudogene
CTHProtein1491 (Entrez Gene)
  • EC 4.4.1.1
  • cystathionase
SAA2Protein6289 (Entrez Gene) serum amyloid A2
PNPOProtein55163 (Entrez Gene)
  • EC 1.4.3.5
  • pyridoxamine 5'-phosphate oxidase
SAA1Protein6288 (Entrez Gene) serum amyloid A1
HemeMetaboliteHMDB03178 (HMDB)
O2MetaboliteHMDB01377 (HMDB)
NADPHMetaboliteHMDB00221 (HMDB) Nicotinamide adenine dinucleotide phosphate-Reduced
PRDX2Protein7001 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 2
Lipoic acidMetaboliteHMDB01451 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
ManganeseMetaboliteHMDB01333 (HMDB)
CystathionineMetaboliteHMDB00099 (HMDB)
FADMetaboliteHMDB01248 (HMDB) Flavin adenine dinucleotide
DihydrolipoateMetaboliteHMDB12210 (HMDB)
Methionine sulfoxideMetaboliteHMDB02005 (HMDB)
ZincMetaboliteHMDB01303 (HMDB)
Dehydroascorbic acidMetabolite17242 (ChEBI)
NiacinMetaboliteHMDB01488 (HMDB)
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Quinolinic AcidMetaboliteHMDB00232 (HMDB)
THFMetaboliteHMDB01846 (HMDB) Tetrahydrofolic acid
O3Metabolite25812 (ChEBI) ozone
HydroxykynurenineMetaboliteHMDB00732 (HMDB)
HNO2Metabolite25567 (ChEBI) Nitrous acid
Folic acidMetaboliteHMDB00121 (HMDB)
HOClMetaboliteHMDB01050 (HMDB) Hypochlorite
SeleniumMetaboliteHMDB01349 (HMDB)
IL1BProtein3553 (Entrez Gene) interleukin 1, beta
Sep15Protein9403 (Entrez Gene) Selenoprotein-15 kDa selenoprotein
CRPProtein1401 (Entrez Gene) C-reactive protein, pentraxin-related
SelKProtein58515 (Entrez Gene) Selenoprotein-selenoprotein K
HbA1cProtein
  • Glycated hemoglobin
  • http://en.wikipedia.org/wiki/Glycated_hemoglobin
GPX 6Protein257202 (Entrez Gene)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 6
sICAM-1Protein3383 (Entrez Gene) soluble intercellular adhesion molecule 1
GSHMetaboliteHMDB00125 (HMDB) Glutathione
FibrinMetabolite439199 (PubChem-compound)
NicotinamidaseProtein3.5.1.19 (Enzyme Nomenclature) Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3 GO:0008936
IL6Protein3569 (Entrez Gene) interleukin 6 (interferon, beta 2)
CalciumMetaboliteHMDB00464 (HMDB)
ALBProtein213 (Entrez Gene) albumin
MethionineMetaboliteHMDB00696 (HMDB)
CCL2Protein6347 (Entrez Gene) chemokine (C-C motif) ligand 2
FMNMetaboliteHMDB01520 (HMDB) Flavin Mononucleotide
FLAPProtein241 (Entrez Gene) arachidonate 5-lipoxygenase-activating protein
SelenophosphateMetabolite16144 (ChEBI)
RiboflavinMetaboliteHMDB00244 (HMDB)
SelenocysteineMetaboliteHMDB03288 (HMDB)
O2-“MetaboliteHMDB02168 (HMDB) Superoxide
SelenideMetabolite15076 (ChEBI)
KynureninaseProtein8942 (Entrez Gene) EC 3.7.1.3
Leukotriene C4MetaboliteHMDB01198 (HMDB)
NitrotyrosineMetaboliteHMDB01904 (HMDB)
GPX 2Protein2877 (Entrez Gene)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 2
Leukotriene E4MetaboliteHMDB02200 (HMDB)
SelPProtein6414 (Entrez Gene) Selenoprotein-selenoprotein P
Leukotriene F4MetaboliteHMDB06465 (HMDB)
Trx-S2Protein7295 (Entrez Gene) oxidized thioredoxin
IronMetaboliteHMDB00692 (HMDB)
Ascorbic acidMetabolite29073 (ChEBI)
FLAD1Protein80308 (Entrez Gene)
  • EC 2.7.7.2
  • FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
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